Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sonja Kriks"'
Publikováno v:
Journal of Developmental Biology, Vol 8, Iss 2, p 9 (2020)
The molecular mechanisms regulating neurogenesis involve the control of gene expression by transcription factors. Gbx1 and Gbx2, two members of the Gbx family of homeodomain-containing transcription factors, are known for their essential roles in cen
Externí odkaz:
https://doaj.org/article/8031cc80160d48abad489a2a1f8f8139
Autor:
Fabiana Perna, Ly P. Vu, Maria Themeli, Sonja Kriks, Ruben Hoya-Arias, Raya Khanin, Todd Hricik, Jorge Mansilla-Soto, Eirini P. Papapetrou, Ross L. Levine, Lorenz Studer, Michel Sadelain, Stephen D. Nimer
Publikováno v:
Stem Cell Reports, Vol 4, Iss 4, Pp 658-669 (2015)
Epigenetic regulation of key transcriptional programs is a critical mechanism that controls hematopoietic development, and, thus, aberrant expression patterns or mutations in epigenetic regulators occur frequently in hematologic malignancies. We demo
Externí odkaz:
https://doaj.org/article/063ec1c46d1b41b4ac0026122cb9bb13
Autor:
Elisa Oricchio, Eirini P. Papapetrou, Fabien Lafaille, Yosif M. Ganat, Sonja Kriks, Ana Ortega-Molina, Willie H. Mark, Julie Teruya-Feldstein, Jason T. Huse, Victor Reuter, Michel Sadelain, Lorenz Studer, Hans-Guido Wendel
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1677-1685 (2014)
The long-term risk of malignancy associated with stem cell therapies is a significant concern in the clinical application of this exciting technology. We report a cancer-selective strategy to enhance the safety of stem cell therapies. Briefly, using
Externí odkaz:
https://doaj.org/article/be1e772e022b4d35bd54296197d25ac4
Autor:
Zehra Dincer, Jinghua Piao, Lei Niu, Yosif Ganat, Sonja Kriks, Bastian Zimmer, Song-Hai Shi, Viviane Tabar, Lorenz Studer
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1387-1402 (2013)
Cranial placodes are embryonic structures essential for sensory and endocrine organ development. Human placode development has remained largely inaccessible despite the serious medical conditions caused by the dysfunction of placode-derived tissues.
Externí odkaz:
https://doaj.org/article/eaf00f37677d4733a437c68bc0ab578f
Autor:
Brittany N. Dubose, Eugene V. Mosharov, Ellen J. Hill, So Yeon Koo, Viviane Tabar, Nicholas D. Socci, Susan Zabierowski, Jinghua Piao, Sonja Kriks, Sun Young Chung, Mark J. Tomishima, Se Joon Choi, Lorenz Studer, Tae Wan Kim, Stefan Irion, Doron Betel
Publikováno v:
Cell stem cell. 28(2)
Human pluripotent stem cells show considerable promise for applications in regenerative medicine, including the development of cell replacement paradigms for the treatment of Parkinson's disease. Protocols have been developed to generate authentic mi
Autor:
Jinghua Piao, Brittany N. Dubose, Claire Henchcliffe, Susan Zabierowski, Wong Karen, Shannon Mann, Kiran Ramnarine, Abderrahman El Maarouf, Nidia L Claros, Craig Fredrickson, Callie Horn, Sonja Kriks, Stefan Irion, Mark J. Tomishima, Brent Safford, Urs Rutishauser, Siera Rosen, Ellen J. Hill, Viviane Tabar, Isabelle Riviere, Lorenz Studer, Monalisa Navare, Vladimir P. Bermudez, Yongzeng Wang
Publikováno v:
Cell stem cell, vol 28, iss 2
Cell Reports Medicine
Cell Reports Medicine
Parkinson's disease is characterized by the loss of dopaminergic neurons in the substantia nigra leading to disabling deficits. Dopamine neuron grafts may provide a significant therapeutic advance over current therapies. We have generated midbrain do
Autor:
Jenny Nelander, Edmund Y. Tu, Malin Parmar, Yosif Ganat, Daniela Battista, Elizabeth L. Calder, Mark J. Tomishima, Fan Jia, Lorenz Studer, Neil L. Harrison, Urs Rutishauser, Sonja Kriks
Publikováno v:
Journal of Clinical Investigation
Journal of Clinical Investigation; Vol 122
Journal of Clinical Investigation; 122(8), pp 2928-2939 (2012)
Journal of Clinical Investigation; Vol 122
Journal of Clinical Investigation; 122(8), pp 2928-2939 (2012)
Embryonic stem cells (ESCs) represent a promising source of midbrain dopaminergic (DA) neurons for applications in Parkinson disease. However, ESC-based transplantation paradigms carry a risk of introducing inappropriate or tumorigenic cells. Cell pu
Autor:
Amanda Buch, M. Flint Beal, Lichuan Yang, Jeffrey H. Kordower, Dustin R. Wakeman, D. James Surmeier, Viviane Tabar, Chris Antonacci, Zhi-Zhong Xie, Jinghua Piao, Sonja Kriks, Luis Carrillo-Reid, Yosif Ganat, Gordon Auyeung, Jae-Won Shim, Lorenz Studer
Publikováno v:
Nature
Nature; Vol
Nature; Vol
Human pluripotent stem cells (PSCs) are a promising source of cells for applications in regenerative medicine. Directed differentiation of PSCs into specialized cells such as spinal motoneurons or midbrain dopamine (DA) neurons has been achieved. How
Autor:
Julius A. Steinbeck, Lorenz Studer, Bastian Zimmer, Wael N. El-Nachef, Tracy C. Grikscheit, Shuibing Chen, Michael D. Gershon, Sarah Kishinevsky, Yvonne Mica, Jason Tchieu, Elisa de Stanchina, Faranak Fattahi, Huiyong Zhao, Nadja Zeltner, Sonja Kriks
Publikováno v:
Nature
The enteric nervous system (ENS) is the largest component of the autonomic nervous system, with neuron numbers surpassing those present in the spinal cord. The ENS has been called the 'second brain' given its autonomy, remarkable neurotransmitter div
Autor:
Ross L. Levine, Ly P. Vu, Fabiana Perna, Stephen D. Nimer, Eirini P. Papapetrou, Lorenz Studer, Sonja Kriks, Michel Sadelain, Ruben Hoya-Arias, Todd Hricik, Jorge Mansilla-Soto, Raya Khanin, Maria Themeli
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 4, Iss 4, Pp 658-669 (2015)
Stem Cell Reports, 4(4), 658-669. Cell Press
Perna, F, Vu, L P, Themeli, M, Kriks, S, Hoya-Arias, R, Khanin, R, Hricik, T, Mansilla-Soto, J, Papapetrou, E P, Levine, R L, Studer, L, Sadelain, M & Nimer, S D 2015, ' The polycomb group protein L3MBTL1 repreßes a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells ', Stem Cell Reports, vol. 4, no. 4, pp. 658-669 . https://doi.org/10.1016/j.stemcr.2015.02.003
Stem Cell Reports, Vol 4, Iss 4, Pp 658-669 (2015)
Stem Cell Reports, 4(4), 658-669. Cell Press
Perna, F, Vu, L P, Themeli, M, Kriks, S, Hoya-Arias, R, Khanin, R, Hricik, T, Mansilla-Soto, J, Papapetrou, E P, Levine, R L, Studer, L, Sadelain, M & Nimer, S D 2015, ' The polycomb group protein L3MBTL1 repreßes a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells ', Stem Cell Reports, vol. 4, no. 4, pp. 658-669 . https://doi.org/10.1016/j.stemcr.2015.02.003
Summary Epigenetic regulation of key transcriptional programs is a critical mechanism that controls hematopoietic development, and, thus, aberrant expression patterns or mutations in epigenetic regulators occur frequently in hematologic malignancies.