Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sonja Krausert"'
Autor:
Alexej Ballhausen, Moritz Jakob Przybilla, Michael Jendrusch, Saskia Haupt, Elisabeth Pfaffendorf, Florian Seidler, Johannes Witt, Alejandro Hernandez Sanchez, Katharina Urban, Markus Draxlbauer, Sonja Krausert, Aysel Ahadova, Martin Simon Kalteis, Pauline L. Pfuderer, Daniel Heid, Damian Stichel, Johannes Gebert, Maria Bonsack, Sarah Schott, Hendrik Bläker, Toni Seppälä, Jukka-Pekka Mecklin, Sanne Ten Broeke, Maartje Nielsen, Vincent Heuveline, Julia Krzykalla, Axel Benner, Angelika Beate Riemer, Magnus von Knebel Doeberitz, Matthias Kloor
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
DNA mismatch repair (MMR)-deficient cancers with microsatellite-instability are characterized by a high load of frameshift mutation-derived neoantigens. Here, by mapping the frameshift mutation landscape and predicting the immunogenicity of the resul
Externí odkaz:
https://doaj.org/article/a73e02cb910a4f8c83a017a74a1f0a13
Autor:
Walter E. Haefeli, Alexander Muck, Ludivine Le Dret, Marius Majewsky, Stefan M. Pfister, Britta Statz, Jürgen Burhenne, Sonja Krausert, David Castel, Julia Benzel, Margaux Fresnais, Rémi Longuespée
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31:742-751
Ion mobility spectrometry (IMS) represents a considerable asset for analytics of complex samples as it allows for rapid mass spectrometric separation of compounds. IMS is even more useful for the separation of isobaric compounds when classical separa
Autor:
Eva Oswald, Kanstantsin Lashuk, Johannes Gojo, Dorothee Lenhard, Norman Mack, Sonja Krausert, Daniela Lötsch, David Jones, Marcel Kool, Till Milde, Walter Berger, Stefan M. Pfister, Julia Schüler
Publikováno v:
Cancer Research. 82:1673-1673
Brain and spinal cord tumors are the second most common group of cancers in children. For children who experience relapses of their tumors, usually after very intensive first-line therapy, curative treatment options are scarce. Thus, the need for pre
Autor:
Anna Laemmerer, Dominik Kirchhofer, Sibylle Madlener, Daniela Loetsch-Gojo, Carola N Jaunecker, Lisa Gabler, Lisa Mayr, Natalia Stepien, Alicia Baumgartner, Karin Dieckmann, Stefan M Pfister, Marcel Kool, Sonja Krausert, Apurva Gopisetty, Natalie Jäger, Andreas Peyrl, Amedeo A Azizi, Walter Berger, Johannes Gojo
Publikováno v:
Neuro-Oncology. 24:i73-i73
Pediatric high-grade gliomas (pHGG) account for approximately 12% of pediatric brain tumors. Despite advances in molecular diagnosis and identification of discrete molecular subtypes, pHGG are the leading cause of cancer-related death in children. Th
Autor:
Sonja Krausert, Norman Mack, Benjamin Schwalm, Heike Peterziel, Ina Oehme, Cornelis M van Tilburg, Olaf Witt, Stefan M Pfister, Marcel Kool
Publikováno v:
Neuro-Oncology. 24:i168-i168
Previously, we have found that Embryonal Tumors with Multilayered Rosettes (ETMR) tumor cells harboring high levels of R-loops, a potential marker for replication stress and genomic instability, are vulnerable to a combination of topoisomerase and PA
Autor:
Elisabeth Pfaffendorf, Saskia Haupt, Hendrik Bläker, Vincent Heuveline, Damian Stichel, Martin Simon Kalteis, Toni T. Seppälä, Axel Benner, Katharina Urban, Sanne W. ten Broeke, Pauline L. Pfuderer, Maartje Nielsen, Markus Draxlbauer, Sarah Schott, Florian Seidler, Julia Krzykalla, Alexej Ballhausen, Magnus von Knebel Doeberitz, Johannes Gebert, Jukka-Pekka Mecklin, Matthias Kloor, Aysel Ahadova, Michael Jendrusch, Alejandro Hernandez Sanchez, Sonja Krausert, Moritz Jakob Przybilla, Daniel Heid, Johannes Witt, Maria Bonsack, Angelika B. Riemer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, 11(1). NATURE RESEARCH
Nature Communications
Nature Communications, 11(1). NATURE RESEARCH
The immune system can recognize and attack cancer cells, especially those with a high load of mutation-induced neoantigens. Such neoantigens are abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR deficiency le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442af0c008e1a3de0b417ae3424d884e
https://hdl.handle.net/1887/3184933
https://hdl.handle.net/1887/3184933
Autor:
Olaf Witt, Maria Łastowska, Anna Darabi, Ulrich Schüller, Andreas von Deimling, Nada Jabado, Susanne Gröbner, David Sumerauer, Annie Huang, Sebastian M. Waszak, Martin Sill, Xiao-Nan Li, Andrey Korshunov, Julien Masliah-Planchon, Pablo Landgraf, David Ellison, Maria J. Gil-da-Costa, Alexander J.R. Bishop, Christin Schmidt, Pieter Wesseling, Sebastian Brabetz, Marc Remke, July Carolina Romero, Dominique Figarella-Branger, Peter Hauser, Simon Papillon-Cavanagh, Jennifer A. Chan, Felix Sahm, Benjamin Schwalm, Peter Lichter, Ivo Buchhalter, Stephan Wolf, Norman Mack, Matthias A. Karajannis, Till Milde, Jan Koster, Valérie Rigau, Monika Mauermann, Matija Snuderl, Franck Bourdeaut, Christine Haberler, Torsten Pietsch, Volker Hovestadt, Wiesława Grajkowska, Katja von Hoff, Felice Giangaspero, Marcel Kool, Emmanuelle Uro-Coste, Jan O. Korbel, Michael D. Taylor, Martin Hasselblatt, Tobias Rausch, Danny A. Zwijnenburg, Jonas Ecker, Brent A. Orr, David T.W. Jones, Jens Schittenhelm, Aparna Gorthi, Sonja Krausert, Sanda Alexandrescu, Sander Lambo, Jens Martin Hübner, Ben Ho, Stefan M. Pfister, Marina Ryzhova
Publikováno v:
Nature
Nature, Nature Publishing Group, 2019, 576 (7786), pp.274-280. ⟨10.1038/s41586-019-1815-x⟩
Nature, 576(7786), 274-280. Nature Publishing Group
Lambo, S, Gröbner, S N, Rausch, T, Waszak, S M, Schmidt, C, Gorthi, A, Romero, J C, Mauermann, M, Brabetz, S, Krausert, S, Buchhalter, I, Koster, J, Zwijnenburg, D A, Sill, M, Hübner, J-M, Mack, N, Schwalm, B, Ryzhova, M, Hovestadt, V, Papillon-Cavanagh, S, Chan, J A, Landgraf, P, Ho, B, Milde, T, Witt, O, Ecker, J, Sahm, F, Sumerauer, D, Ellison, D W, Orr, B A, Darabi, A, Haberler, C, Figarella-Branger, D, Wesseling, P, Schittenhelm, J, Remke, M, Taylor, M D, Gil-da-Costa, M J, Łastowska, M, Grajkowska, W, Hasselblatt, M, Hauser, P, Pietsch, T, Uro-Coste, E, Bourdeaut, F, Masliah-Planchon, J, Rigau, V, Alexandrescu, S, Wolf, S, Li, X-N, Schüller, U, Snuderl, M, Karajannis, M A, Giangaspero, F, Jabado, N, von Deimling, A, Jones, D T W, Korbel, J O, von Hoff, K, Lichter, P, Huang, A, Bishop, A J R, Pfister, S M, Korshunov, A & Kool, M 2019, ' The molecular landscape of ETMR at diagnosis and relapse ', Nature, vol. 576, no. 7786, pp. 274-280 . https://doi.org/10.1038/s41586-019-1815-x
Nature, 2019, 576 (7786), pp.274-280. ⟨10.1038/s41586-019-1815-x⟩
Nature, Nature Publishing Group, 2019, 576 (7786), pp.274-280. ⟨10.1038/s41586-019-1815-x⟩
Nature, 576(7786), 274-280. Nature Publishing Group
Lambo, S, Gröbner, S N, Rausch, T, Waszak, S M, Schmidt, C, Gorthi, A, Romero, J C, Mauermann, M, Brabetz, S, Krausert, S, Buchhalter, I, Koster, J, Zwijnenburg, D A, Sill, M, Hübner, J-M, Mack, N, Schwalm, B, Ryzhova, M, Hovestadt, V, Papillon-Cavanagh, S, Chan, J A, Landgraf, P, Ho, B, Milde, T, Witt, O, Ecker, J, Sahm, F, Sumerauer, D, Ellison, D W, Orr, B A, Darabi, A, Haberler, C, Figarella-Branger, D, Wesseling, P, Schittenhelm, J, Remke, M, Taylor, M D, Gil-da-Costa, M J, Łastowska, M, Grajkowska, W, Hasselblatt, M, Hauser, P, Pietsch, T, Uro-Coste, E, Bourdeaut, F, Masliah-Planchon, J, Rigau, V, Alexandrescu, S, Wolf, S, Li, X-N, Schüller, U, Snuderl, M, Karajannis, M A, Giangaspero, F, Jabado, N, von Deimling, A, Jones, D T W, Korbel, J O, von Hoff, K, Lichter, P, Huang, A, Bishop, A J R, Pfister, S M, Korshunov, A & Kool, M 2019, ' The molecular landscape of ETMR at diagnosis and relapse ', Nature, vol. 576, no. 7786, pp. 274-280 . https://doi.org/10.1038/s41586-019-1815-x
Nature, 2019, 576 (7786), pp.274-280. ⟨10.1038/s41586-019-1815-x⟩
Embryonal tumours with multilayered rosettes (ETMRs) are aggressive paediatric embryonal brain tumours with a universally poor prognosis1. Here we collected 193 primary ETMRs and 23 matched relapse samples to investigate the genomic landscape of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a9fb34e854ed244d44bc4f785f2b10
https://hal.archives-ouvertes.fr/hal-02441051
https://hal.archives-ouvertes.fr/hal-02441051
Autor:
Andreas Unterberg, Hartmut Rehwinkel, Ann Christin Beck, Felix Sahm, Michael Platten, Daniel Schrimpf, Stefan Kaulfuss, Wolfgang Wick, Olaf Panknin, Holger Hess-Stumpp, Roland Neuhaus, Roman C. Hillig, Judith Guenther, David Capper, Andrea Haegebart, Luisella Toschi, Markus Bauser, Stefan Pusch, Manfred Jugold, Martina Ott, Christel Herold-Mende, Katja Zimmermann, Jörg Balss, Jessica Eisel, Sonja Krausert, Viktoria Eichwald, Viktoria Fischer, Andreas von Deimling
Publikováno v:
Acta Neuropathologica. 133:629-644
Mutations in codon 132 of isocitrate dehydrogenase (IDH) 1 are frequent in diffuse glioma, acute myeloid leukemia, chondrosarcoma and intrahepatic cholangiocarcinoma. These mutations result in a neomorphic enzyme specificity which leads to a dramatic
Autor:
Matthias Kloor, Moritz Jakob Przybilla, Sonja Krausert, Angelika B. Riemer, Martin Simon Kalteis, Michael Jendrusch, Vincent Heuveline, Aysel Ahadova, Magnus von Knebel Doeberitz, Toni T. Seppälä, Axel Benner, Daniel Heid, Sanne W. ten Broeke, Maartje Nielsen, Saskia Haupt, Jukka-Pekka Mecklin, Johannes Gebert, Markus Draxlbauer, Sarah Schott, Maria Bonsack, Florian Seidler, Julia Krzykalla, Elisabeth Pfaffendorf, Hendrik Bläker, Alexej Ballhausen
The immune system can recognize and attack cancer cells, especially those with a high load of mutation-inducedneoantigens. Suchneoantigens are particularly abundant in DNA mismatch repair (MMR)-deficient, microsatellite-unstable (MSI) cancers. MMR de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1714bb8f5451a38fbcb42af5c81ebb3
https://doi.org/10.1101/691469
https://doi.org/10.1101/691469
Autor:
Sander Lambo, Norman Mack, Marcel Kool, Sonja Krausert, Sebastian Brabetz, Stefan M. Pfister, Benjamin Schwalm
Pediatric brain tumors frequently harbor MYC- or MYCN-amplification or show high overexpression and are associated with poor outcome. Examples for which current treatments are unsuccessful are for instance the medulloblastoma (MB) subgroups SHH (MYCN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96362d899f42788ab9fc33938dd870fb
https://europepmc.org/articles/PMC6477285/
https://europepmc.org/articles/PMC6477285/