ABCB5 Identifies Immunoregulatory Dermal Cells

Autor: Tobias Schatton, Jun Yang, Sonja Kleffel, Mayuko Uehara, Steven R. Barthel, Christoph Schlapbach, Qian Zhan, Stephen Dudeney, Hansgeorg Mueller, Nayoung Lee, Juliane C. de Vries, Barbara Meier, Seppe Vander Beken, Mark A. Kluth, Christoph Ganss, Arlene H. Sharpe, Ana Maria Waaga-Gasser, Mohamed H. Sayegh, Reza Abdi, Karin Scharffetter-Kochanek, George F. Murphy, Thomas S. Kupper, Natasha Y. Frank, Markus H. Frank

Publikováno v: Cell Reports, Vol 12, Iss 10, Pp 1564-1574 (2015)

Cell-based strategies represent a new frontier in the treatment of immune-mediated disorders. However, the paucity of markers for isolation of molecularly defined immunomodulatory cell populations poses a barrier to this field. Here, we show that ATP

Externí odkaz: https://doaj.org/article/129d152adc6c47cc837c0b20e8d98b09

Combined Inhibition of MEK and Plk1 Has Synergistic Antitumor Activity in NRAS Mutant Melanoma

Autor: Nihal Ahmad, Martina Sanlorenzo, Igor Vujic, Sarasa T. Kim, Christian Posch, Jeffrey Ma, Brian D. Cholewa, Susana Ortiz-Urda, Tobias Schatton, Sonja Kleffel, Klemens Rappersberger, Rosie Elizabeth Ann Gutteridge

Publikováno v: Journal of Investigative Dermatology. 135(10):2475-2483

About one-third of cancers harbor activating mutations in rat sarcoma viral oncogene homolog (RAS) oncogenes. In melanoma, aberrant neuroblastoma-RAS (NRAS) signaling fuels tumor progression in about 20% of patients. Current therapeutics for NRAS–d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fec9786f349920032a24b539ba990d

Nestin depletion induces melanoma matrix metalloproteinases and invasion

Autor: Markus H. Frank, George F. Murphy, Jennifer Y. Lin, Christine G. Lian, Tobias Schatton, Allison R. Larson, Chung-Wei Lee, Jie Ma, John Huang, Sonja Kleffel, Qian Zhan, Marilyn T. Wan, Ping-I Lin, Cecilia Lezcano

Publikováno v: Laboratory investigation; a journal of technical methods and pathology

Matrix metalloproteinases (MMPs) are key biological mediators of processes as diverse as wound healing, embryogenesis, and cancer progression. Although MMPs may be induced through multiple signaling pathways, the precise mechanisms for their regulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b45b769288151c6878b3d0372734ea
https://doi.org/10.1038/labinvest.2014.130

Modified CD4+ T-cell response in recipients of old cardiac allografts

Autor: I. Kim, Paolo Fiorina, Robert F. Padera, Stefan G. Tullius, Christian Denecke, Johann Pratschke, Xupeng Ge, Anke Jurisch, Sonja Kleffel, Anne Weiland

Publikováno v: Transplant International. 25:328-336

Summary With an increasing demand, organs from elderly donors are more frequently utilized for transplantation. Herein, we analyzed the impact of donor age on CD4+ T-cell responses with regard to regulatory and effector mechanisms. Young (3 months) B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbb6ec01ba5917ca8932e142d244ac4f
https://doi.org/10.1111/j.1432-2277.2011.01417.x

ABCB5 Identifies Immunoregulatory Dermal Cells

Autor: Christoph Ganss, Jun Yang, Markus H. Frank, Arlene H. Sharpe, George F. Murphy, Barbara Meier, Christoph Schlapbach, Juliane C. de Vries, Nayoung Lee, Ana Maria Waaga-Gasser, Mayuko Uehara, Steven R. Barthel, Seppe Vander Beken, Thomas S. Kupper, Natasha Y. Frank, Reza Abdi, Sonja Kleffel, Hansgeorg Mueller, Mohamed H. Sayegh, Mark A. Kluth, Stephen Dudeney, Tobias Schatton, Karin Scharffetter-Kochanek, Qian Zhan

Publikováno v: Schatton, Tobias; Yang, Jun; Kleffel, Sonja; Uehara, Mayuko; Barthel, Steven R; Schlapbach, Christoph; Zhan, Qian; Dudeney, Stephen; Mueller, Hansgeorg; Lee, Nayoung; de Vries, Juliane C; Meier, Barbara; Vander Beken, Seppe; Kluth, Mark A; Ganss, Christoph; Sharpe, Arlene H; Waaga-Gasser, Ana Maria; Sayegh, Mohamed H; Abdi, Reza; Scharffetter-Kochanek, Karin; ... (2015). ABCB5 Identifies Immunoregulatory Dermal Cells. Cell reports, 12(10), pp. 1564-1574. Cell Press 10.1016/j.celrep.2015.08.010
Cell Reports, Vol 12, Iss 10, Pp 1564-1574 (2015)

Cell-based strategies represent a new frontier in the treatment of immune-mediated disorders. However, the paucity of markers for isolation of molecularly defined immunomodulatory cell populations poses a barrier to this field. Here, we show that ATP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9efffceffa9b823a2093b8ae5ba2163
https://boris.unibe.ch/76585/1/1-s2.0-S2211124715008815-main.pdf