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Autor:
Jernej Wagger, David Kralj, Miha Friedrich, Anton Meden, Jurij Svete, Uroš Grošelj, Sonja Kiraly-Potpara, Georg Dahmann, Branko Stanovnik
Publikováno v:
Tetrahedron. 65:7151-7162
A seven-step synthesis of 1-substituted 5-(2-acylaminoethyl)-1H-pyrazole-4-carboxamides 20 as the pyrazole analogues of histamine was developed. The synthesis starts with a three-step preparation of N(1)-substituted methyl 5-(2-tert-butoxycarbonylami