Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sonja Kazmer"'
Autor:
Rebecca Taub, Weiya Yun, Toni Whittard, David Robert Bolin, Yimin Qian, Shiming Li, Paul Gillespie, Sonja Kazmer, Yingsi Chen, Mushtaq Ahmad, Stanley Wertheimer, Karin Conde-Knape
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7205-7209
In a discovery effort to find safe and effective DGAT-1 inhibitors, we have identified 2-phenyloxazole 4-carboxamide 1 as a conformationally constrained analog of a hydrazide hit, which was previously identified from high-throughput screening. Furthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22686f43ba28ecf4b6fd5f817ee02e70
https://doi.org/10.1016/j.bmcl.2011.09.039
https://doi.org/10.1016/j.bmcl.2011.09.039
Publikováno v:
Journal of Biological Chemistry. 269:16689-16695
Both 9-cis-retinoic acid (RA) and all-trans-RA (t-RA) compete for [3H]9-cis-RA binding to RA receptors (RAR alpha, beta, and gamma) in nucleosol fractions from transiently transfected COS-1 cells with IC50 values of approximately 12 and 5 nM, respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a47c2b3eb9488b5d4aa2766d8a17066c
https://doi.org/10.1016/s0021-9258(19)89445-0
https://doi.org/10.1016/s0021-9258(19)89445-0
Autor:
Joseph F. Grippo, Sonja Kazmer, P Abarzúa, Laurie J. Sturzenbecker, Bonnie F. Tate, Arthur A. Levin, J Speck, R Janocha, Gary Allenby
Publikováno v:
Molecular and Cellular Biology. 14:2323-2330
Retinoids exert their physiological action by interacting with two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which regulate gene expression by forming transcriptionally active heterodimeric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86cf93449e1923268f94050c0f53e6f7
https://doi.org/10.1128/mcb.14.4.2323
https://doi.org/10.1128/mcb.14.4.2323
Autor:
Philippe Kastner, J Speck, Pierre Chambon, Sonja Kazmer, M Saunders, Michael Rosenberger, Joseph F. Grippo, Allen John Lovey, Gary Allenby, M T Bocquel
Publikováno v:
Proceedings of the National Academy of Sciences. 90:30-34
The binding of endogenous retinoids and stereoisomers of retinoic acid (RA) to the retinoid nuclear receptors, RA receptor (RARs) and retinoid X receptors (RXRs), was characterized using nucleosol preparations from transiently transfected COS-1 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7dd7d366a5e1c34ce4d6ddfdabc1c8
https://doi.org/10.1073/pnas.90.1.30
https://doi.org/10.1073/pnas.90.1.30
Autor:
Joseph F. Grippo, Gary Allenby, Thomas Bosakowski, Laurie J. Sturzenbecker, Michael Rosenberger, Arthur A. Levin, Cl. Kratzeisen, Allen John Lovey, Christine Huselton, J Speck, Sonja Kazmer
Publikováno v:
Annals of the New York Academy of Sciences. 669:70-85
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1876451738b3240838bdc68261d7761
https://doi.org/10.1111/j.1749-6632.1992.tb17090.x
https://doi.org/10.1111/j.1749-6632.1992.tb17090.x
Autor:
Arthur A. Levin, Laurie J. Sturzenbecker, Sonja Kazmer, Thomas Bosakowski, Christine Huselton, Gary Allenby, Jeffrey Speck, Cl. ratzeisen, Michael Rosenberger, Allen Lovey, Joseph F. Grippo
Publikováno v:
Nature. 355:359-361
Vitamin A (retinol) and its natural derivatives are required for many physiological processes. The activity of retinoids is thought to be mediated by interactions with two subfamilies of nuclear retinoic acid receptors, RAR and RXR. The RARs bind all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bc2e1df7f22e144936c164122d5c64
https://doi.org/10.1038/355359a0
https://doi.org/10.1038/355359a0
Publikováno v:
Journal of biochemical and biophysical methods. 40(3)
An improved telomerase assay was developed that allows direct quantification of the enzyme activity by scintillation counting of the labeled telomerase product. The assay measures the incorporation of 32 P-dGTP into telomeric repeats synthesized at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682afffeda5be48dfd0c6c4713af7248
https://pubmed.ncbi.nlm.nih.gov/10487165
https://pubmed.ncbi.nlm.nih.gov/10487165
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 46:297-303
The human diploid fibroblast culture, WI-38 was analyzed for chromosomal damage after 24 h exposures to benzo(a)pyrene (BP), 3-methylcholanthrene (MCA), n-methyl-n'-nitrosoguanidine (MNNG), 4-nitroquinoline-1-oxide (4NQO), pyrene and caffeine. A low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574e4a52c2de7181e64d92931b7f1722
https://doi.org/10.1016/0165-1161(77)90006-1
https://doi.org/10.1016/0165-1161(77)90006-1
Publikováno v:
Environmental Mutagenesis. 5:541-551
Various methods were used to reconstruct an environment similar to a chemically bactericidal or bacteriostatic effect in the Ames mutagenicity assay in order to determine whether a false-positive result could occur. Neither population reduction, soni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eac30cbe111d64f0140727c5926b430
https://doi.org/10.1002/em.2860050404
https://doi.org/10.1002/em.2860050404
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 20:441-443
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87261ffa268b01b57841c881b05cf728
https://doi.org/10.1016/0027-5107(73)90066-3
https://doi.org/10.1016/0027-5107(73)90066-3