Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sonja J. Heidorn"'
Autor:
Rinshi S. Kasai, Richard Marais, Jin Hee Park, Sarah J. Plowman, Kwang Jin Cho, John F. Hancock, Dharini van der Hoeven, Sravanthi Chigurupati, Sonja J. Heidorn, Akihiro Kusumi
Publikováno v:
Current Biology. 22:945-955
Summary Background The lateral segregation of Ras proteins into transient plasma membrane nanoclusters is essential for high-fidelity signal transmission by the Ras mitogen-activated protein kinase (MAPK) cascade. In this spatially constrained signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbfdac695fa84489b7d64dfb7c2abf2
https://doi.org/10.1016/j.cub.2012.03.067
https://doi.org/10.1016/j.cub.2012.03.067
Autor:
Xeni Mitropoulos, Jae Won Chang, Daniel A. Haber, Jeffrey Settleman, Wanjuan Yang, I. Richard Thompson, Julio Saez-Rodriguez, Nathanael S. Gray, Olivier Delattre, Jeffrey A. Engelman, Qingsong Liu, Sonja J. Heidorn, José Baselga, Michael R. Stratton, Karl P. Lawrence, Helen Davies, Stephen R. Lutz, Li Chen, Helen Thi, Graham R. Bignell, Randy J. Milano, Anne McLaren-Douglas, Anahita Dastur, Sridhar Ramaswamy, Sreenath V. Sharma, Jesse A. Stevenson, Patricia Greninger, Jessica L. Boisvert, King Wai Lau, Xi Luo, Tatiana Mironenko, Xianming Deng, Christopher Greenman, Fiona Kogera, P. Andrew Futreal, Tinghu Zhang, Patrick O’Brien, Syd Barthorpe, F Jewitt, Ultan McDermott, Hwan Geun Choi, Mathew J. Garnett, Ivan Stamenkovic, Francesco Iorio, Wooyoung Hur, Stacey Price, Jorge Soares, Laura Richardson, Wenjun Zhou, Cyril H. Benes, Ah Ting Tam, Adam Butler, Elena J. Edelman, Didier Surdez
Publikováno v:
Nature
Nature, vol. 483, no. 7391, pp. 570-575
Nature, vol. 483, no. 7391, pp. 570-575
Clinical responses to anticancer therapies are often restricted to a subset of patients. In some cases, mutated cancer genes are potent biomarkers for responses to targeted agents. Here, to uncover new biomarkers of sensitivity and resistance to canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d30c7a49863ef53126248c5b26aafba
http://europepmc.org/articles/PMC3349233
http://europepmc.org/articles/PMC3349233
Autor:
Christopher A. Eide, Brian J. Druker, Ion Niculescu-Duvaz, Richard Marais, Leisl M. Packer, Sareena Rana, Matthew S. Zabriskie, Caroline J. Springer, Sonja J. Heidorn, Thomas O'Hare, Ana Paula Rebocho, Robert Hayward
Publikováno v:
Cancer Cell. 20:715-727
SummaryWe show that imatinib, nilotinib, and dasatinib possess weak off-target activity against RAF and, therefore, drive paradoxical activation of BRAF and CRAF in a RAS-dependent manner. Critically, because RAS is activated by BCR-ABL, in drug-resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7528931eaf949a516d35d6edc0c3cd
https://doi.org/10.1016/j.ccr.2011.11.004
https://doi.org/10.1016/j.ccr.2011.11.004
Autor:
Richard Marais, Jorge S. Reis-Filho, Nathalie Dhomen, Arnaud Nourry, Caroline J. Springer, Carla Milagre, Ion Niculescu-Duvas, Catrin Pritchard, Sonja J. Heidorn, Steven R. Whittaker, Jahan Hussain
Publikováno v:
Cell. 140(2)
SummaryWe describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the presence of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive RAS-dependent BRAF binding to CRAF, CRAF activation, and MEK–ERK signaling. This d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5544f3a06266ce3ff4bb37d48f85bc3
https://pubmed.ncbi.nlm.nih.gov/20535844
https://pubmed.ncbi.nlm.nih.gov/20535844