Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sonja Horte"'
Autor:
Rajesh A. Shenoi, Sonja Horte, Irina Chafeeva, Benjamin F.L. Lai, Jayachandran N. Kizhakkedathu
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 53:2104-2115
Publikováno v:
Biomaterials. 35:278-286
Solid tumors generally exhibit an acidic microenvironment which has been recognized as a potential route to distinguishing tumor from normal tissue for purposes of drug delivery or imaging. To this end we describe a pH and temperature sensitive polym
Autor:
Jayachandran N. Kizhakkedathu, Rajesh A. Shenoi, Sonja Horte, Jasmine L. Hamilton, Benjamin F.L. Lai, Iren Constantinescu, Heather A. Leitch, Muhammad Imran ul-haq
Publikováno v:
ACS Nano. 7:10704-10716
Patients requiring chronic red blood cell (RBC) transfusions for inherited or acquired anemias are at risk of developing transfusional iron overload, which may impact negatively on organ function and survival. Current iron chelators are suboptimal du
Publikováno v:
Macromolecular Bioscience. 14:334-339
A new monomer, 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl methacrylate (AEO4 MA), and its direct atom transfer radical polymerization (ATRP) into poly(AEO4 MA), then "clicked" with prop-2-ynyle choline phosphate (CP) to produce a poly(choline phospha
Autor:
Jasmine L. Hamilton, Jayaprakash K. Narayanannair, Rajesh K. Kainthan, Sonja Horte, Benjamin F.L. Lai, Jos P. Varghese, Jayachandran N. Kizhakkedathu, Rajesh A. Shenoi, Muthiah Manoharan, Kallanthottathil G. Rajeev
Publikováno v:
Journal of the American Chemical Society. 134:14945-14957
Multifunctional biocompatible and biodegradable nanomaterials incorporating specific degradable linkages that respond to various stimuli and with defined degradation profiles are critical to the advancement of targeted nanomedicine. Herein we report,
Autor:
Donald E. Brooks, Jayachandran N. Kizhakkedathu, Wei Chen, Xifei Yu, Johan Janzen, Irina Chafeeva, Zonghua Liu, Sonja Horte, Rajesh K. Kainthan
Publikováno v:
Nature Materials. 11:468-476
Phospholipids in the cell membranes of all eukaryotic cells contain phosphatidyl choline (PC) as the headgroup. Here we show that hyperbranched polyglycerols (HPGs) decorated with the 'PC-inverse' choline phosphate (CP) in a polyvalent fashion can el
Autor:
Ibrahim Mustafa, Mark D. Scott, Jayachandran N. Kizhakkedathu, Sonja Horte, Nicholas A. A. Rossi, Helen M. Burt, John K. Jackson
Publikováno v:
Biomaterials. 30:638-648
Desferrioxamine (DFO) is used to treat an excess accumulation of iron in the body and is currently the most commonly used iron chelator for the treatment of 'iron overload' disorder. However, the disadvantages of DFO surround its high toxicity and ve
Autor:
Michael S. Kobor, Miki, Andrew Emili, Grant W. Brown, Steven J. Brill, Sonja Horte, Jennifer W. Gin, Tania Michelle Roberts, Jasper Rine, Suzanne A. Bastin-Shanower
Publikováno v:
Molecular Biology of the Cell. 17:539-548
RTT107 (ESC4, YHR154W) encodes a BRCA1 C-terminal-domain protein that is important for recovery from DNA damage during S phase. Rtt107 is a substrate of the checkpoint protein kinase Mec1, although the mechanism by which Rtt107 is targeted by Mec1 af
Publikováno v:
Macromolecular bioscience. 14(3)
A new monomer, 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl methacrylate (AEO4 MA), and its direct atom transfer radical polymerization (ATRP) into poly(AEO4 MA), then "clicked" with prop-2-ynyle choline phosphate (CP) to produce a poly(choline phospha
Autor:
Jayachandran N. Kizhakkedathu, Sonja Horte, Xifei Yu, Johan Janzen, Donald E. Brooks, Yuquan Zou
Publikováno v:
Biomacromolecules. 14(8)
Multivalent macromolecular associations are widely observed in biological systems and are increasingly being utilized in bioengineering, nanomedicine, and biomaterial applications. Control over such associations usually demands an ability to reverse