Zobrazeno 1 - 10 of 51 pro vyhledávání: '"Sonja Hinz"'
1
Akademický článek
Adenosine A2A receptor agonists with potent antiplatelet activity
Autor: Eduardo Fuentes, Manuel Fuentes, Julio Caballero, Iván Palomo, Sonja Hinz, Ali El-Tayeb, Christa E. Müller
Publikováno v: Platelets, Vol 29, Iss 3, Pp 292-300 (2018)
Selected adenosine A2A receptor agonists (PSB-15826, PSB-12404, and PSB-16301) have been evaluated as new antiplatelet agents. In addition, radioligand-binding studies and receptor-docking experiments were performed in order to explain their differen
Externí odkaz: https://doaj.org/article/c1999199e4b74c0582d84cf1a00f4d11
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2
Akademický článek
Synthesis of Novel Fluorinated Xanthine Derivatives with High Adenosine A2B Receptor Binding Affinity
Autor: Marcel Lindemann, Sladjana Dukic-Stefanovic, Sonja Hinz, Winnie Deuther-Conrad, Rodrigo Teodoro, Cathleen Juhl, Jörg Steinbach, Peter Brust, Christa E. Müller, Barbara Wenzel
Publikováno v: Pharmaceuticals, Vol 14, Iss 5, p 485 (2021)
The G protein-coupled adenosine A2B receptor is suggested to be involved in various pathological processes accompanied by increased levels of adenosine as found in inflammation, hypoxia, and cancer. Therefore, the adenosine A2B receptor is currently
Externí odkaz: https://doaj.org/article/8fffc158d73a484d866392b9189d0100
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3
Akademický článek
Probing Substituents in the 1- and 3-Position: Tetrahydropyrazino-Annelated Water-Soluble Xanthine Derivatives as Multi-Target Drugs With Potent Adenosine Receptor Antagonistic Activity
Autor: Pierre Koch, Andreas Brunschweiger, Vigneshwaran Namasivayam, Stefan Ullrich, Annalisa Maruca, Beatrice Lazzaretto, Petra Küppers, Sonja Hinz, Jörg Hockemeyer, Michael Wiese, Jag Heer, Stefano Alcaro, Katarzyna Kiec-Kononowicz, Christa E. Müller
Publikováno v: Frontiers in Chemistry, Vol 6 (2018)
Tetrahydropyrazino-annelated theophylline (1,3-dimethylxanthine) derivatives have previously been shown to display increased water-solubility as compared to the parent xanthines due to their basic character. In the present study, we modified this pro
Externí odkaz: https://doaj.org/article/8ac885faa3b14e47a630ed6570da0d0f
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4
Akademický článek
Understanding the Role of Adenosine A2AR Heteroreceptor Complexes in Neurodegeneration and Neuroinflammation
Autor: Dasiel O. Borroto-Escuela, Sonja Hinz, Gemma Navarro, Rafael Franco, Christa E. Müller, Kjell Fuxe
Publikováno v: Frontiers in Neuroscience, Vol 12 (2018)
Adenosine is a nucleoside mainly formed by degradation of ATP, located intracellularly or extracellularly, and acts as a neuromodulator. It operates as a volume transmission signal through diffusion and flow in the extracellular space to modulate the
Externí odkaz: https://doaj.org/article/efb4b78867d542cf9b11306ae9613708
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5
The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors
Autor: Pedro Valada, Sonja Hinz, Christin Vielmuth, Cátia R. Lopes, Rodrigo A. Cunha, Christa E. Müller, João Pedro Lopes
Publikováno v: Purinergic Signal
Inosine has robust neuroprotective effects, but it is unclear if inosine acts as direct ligand of adenosine receptors or if it triggers metabolic effects indirectly modifying the activity of adenosine receptors. We now combined radioligand binding st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8cb78cc0d623262b9eb75ce0a79ebe
https://europepmc.org/articles/PMC10247617/
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6
Adenosine A2AR/A1R Antagonists Enabling Additional H3R Antagonism for the Treatment of Parkinson’s Disease
Autor: Stefanie Hagenow, Vigneshwaran Namasivayam, Sonja Hinz, Christa E. Müller, Anna Affini, Jian-Sheng Lin, Erwan Bezard, Holger Stark, Elsa Y. Pioli, Yan Zhao, Gregory Porras
Publikováno v: Journal of Medicinal Chemistry. 64:8246-8262
Adenosine A1/A2A receptors (A1R/A2AR) represent targets in nondopaminergic treatment of motor disorders such as Parkinson's disease (PD). As an innovative strategy, multitargeting ligands (MTLs) were developed to achieve comprehensive PD therapies si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4948915e4ea9b400c77f16573765daf6
https://doi.org/10.1021/acs.jmedchem.0c00914
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8
Discovery and Structure Relationships of Salicylanilide Derivatives as Potent, Non-acidic P2X1 Receptor Antagonists
Autor: Sabrina Densborn, Sonja Hinz, Ralf Schmid, Aliaa Abdelrahman, Claudia Spanier, Christa E. Müller, Younis Baqi, Djamil Azazna, Eduardo Fuentes, Maoqun Tian
Publikováno v: Journal of Medicinal Chemistry. 63:6164-6178
Antagonists for the ATP-gated ion channel receptor P2X1 have potential as antithrombotics and for treating hyperactive bladder and inflammation. In this study, salicylanilide derivatives were synthesized based on a screening hit. P2X1 antagonistic po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14dfd5a60d260af345c15b2d83e98659
https://doi.org/10.1021/acs.jmedchem.0c00435
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