Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sonja Ghidelli-Disse"'
Autor:
William F. Mueller, Petra Jakob, Han Sun, Sandra Clauder-Münster, Sonja Ghidelli-Disse, Diana Ordonez, Markus Boesche, Marcus Bantscheff, Paul Collier, Bettina Haase, Vladimir Benes, Malte Paulsen, Peter Sehr, Joe Lewis, Gerard Drewes, Lars M. Steinmetz
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 5, Pp 1585-1597 (2020)
N-Glycanase 1 (NGLY1) deficiency is an ultra-rare, complex and devastating neuromuscular disease. Patients display multi-organ symptoms including developmental delays, movement disorders, seizures, constipation and lack of tear production. NGLY1 is a
Externí odkaz:
https://doaj.org/article/adddb7444aae428d91b8ff0efc9baf92
Autor:
Alice R. Moorey, Alejandro Cabanillas, Sarah M. Batt, Sonja Ghidelli-Disse, Beatriz Urones, Olalla Sanz, Joel Lelievre, Marcus Bantscheff, Liam R. Cox, Gurdyal S. Besra
Publikováno v:
The Cell Surface, Vol 7, Iss , Pp 100068- (2021)
The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) ensures that drug discovery efforts remain at the forefront of TB research. There are multiple different experimental approaches that can be employed in the discovery of anti
Externí odkaz:
https://doaj.org/article/a33fd1f698b0424ca7a367765fd2c89c
Autor:
Maria Penzo, Laura de las Heras-Dueña, Lydia Mata-Cantero, Beatriz Diaz-Hernandez, Maria-Jesus Vazquez-Muñiz, Sonja Ghidelli-Disse, Gerard Drewes, Elena Fernandez-Alvaro, David A. Baker
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential functions in all of the major life cycle developmental
Externí odkaz:
https://doaj.org/article/7b1853796974419994e20d37569169f5
Autor:
Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S. Gurcha, Jonathan A. G. Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J. Loman, Patrick J. Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C. Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S. Besra, Robert H. Bates
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Screens for bactericidal compounds have resulted in promising anti-tubercular hits. Here, the authors analyse in detail the target of an indazole sulfonamide (GSK3011724A), and find that it has a different mode of inhibition compared to other Kas inh
Externí odkaz:
https://doaj.org/article/98e2a1212a5248b996b2c2ff78fce60e
Autor:
Gregory J Crowther, Heidi K Hillesland, Katelyn R Keyloun, Molly C Reid, Maria Jose Lafuente-Monasterio, Sonja Ghidelli-Disse, Stephen E Leonard, Panqing He, Jackson C Jones, Mallory M Krahn, Jack S Mo, Kartheek S Dasari, Anna M W Fox, Markus Boesche, Majida El Bakkouri, Kasey L Rivas, Didier Leroy, Raymond Hui, Gerard Drewes, Dustin J Maly, Wesley C Van Voorhis, Kayode K Ojo
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0149996 (2016)
In 2010 the identities of thousands of anti-Plasmodium compounds were released publicly to facilitate malaria drug development. Understanding these compounds' mechanisms of action--i.e., the specific molecular targets by which they kill the parasite-
Externí odkaz:
https://doaj.org/article/5e2950d857f248d1802b59df2efcbcbc
Autor:
María L. Guantay, Cintia A. Garro, Sebastian Siri, María Pansa, Sonja Ghidelli-Disse, Natalia Paviolo, Ana Racca, Viviana Nicotra, Caius Radu, José L. Bocco, Rosana Felice, Israel Gloger, Marcel Muelbaier, Gerard Drewes, Kevin Madauss, Manuela García, Vanesa Gottifredi, Gastón Soria
Publikováno v:
Cancer Research. 83:P4-08
BRCA2 is a well-established cancer driver in several human malignancies. While the remarkable success of PARP inhibitors proved the clinical potential of targeting BRCA deficiencies, the emergence of resistance mechanisms underscores the importance o
Autor:
Vinayak Singh, Anna E. Grzegorzewicz, Stephen Fienberg, Rudolf Müller, Lutete Peguy Khonde, Olalla Sanz, Salvatore Alfonso, Beatriz Urones, Gerard Drewes, Marcus Bantscheff, Sonja Ghidelli-Disse, Thomas R. Ioerger, Bhanupriya Angala, Jiuyu Liu, Richard E. Lee, James C. Sacchettini, Inna V. Krieger, Mary Jackson, Kelly Chibale, Sandeep R. Ghorpade
Publikováno v:
ACS Infectious Diseases. 8:2315-2326
Autor:
Benedikt Rauscher, William F Mueller, Sandra Clauder-Münster, Petra Jakob, M Saiful Islam, Han Sun, Sonja Ghidelli-Disse, Markus Boesche, Marcus Bantscheff, Hannah Pflaumer, Paul Collier, Bettina Haase, Songjie Chen, Rene Hoffman, Guangwen Wang, Vladimir Benes, Gerard Drewes, Michael Snyder, Lars M Steinmetz
Publikováno v:
The Journal of Biochemistry. 171:187-199
N-Glycanase 1 (NGLY1) deficiency is a rare and complex genetic disorder. Although recent studies have shed light on the molecular underpinnings of NGLY1 deficiency, a systematic characterization of gene and protein expression changes in patient-deriv
Autor:
Lauren B. Arendse, James M. Murithi, Tarrick Qahash, Charisse Flerida A. Pasaje, Luiz C. Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, Maria J. Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte van der Watt, Janette Reader, Ayesha S. Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R. Luth, Sabine Ottilie, Elizabeth A. Winzeler, Lizette L. Koekemoer, Lyn-Marie Birkholtz, Jacquin C. Niles, Manuel Llinás, David A. Fidock, Kelly Chibale
Publikováno v:
Science Translational Medicine. 14
Compounds acting on multiple targets are critical to combating antimalarial drug resistance. Here, we report that the human “mammalian target of rapamycin” (mTOR) inhibitor sapanisertib has potent prophylactic liver stage activity, in vitro and i
Autor:
Marion Flipo, Rosangela Frita, Marilyne Bourotte, María S. Martínez-Martínez, Markus Boesche, Gary W. Boyle, Geo Derimanov, Gerard Drewes, Pablo Gamallo, Sonja Ghidelli-Disse, Stephanie Gresham, Elena Jiménez, Jaime de Mercado, Esther Pérez-Herrán, Esther Porras-De Francisco, Joaquín Rullas, Patricia Casado, Florence Leroux, Catherine Piveteau, Mehdi Kiass, Vanessa Mathys, Karine Soetaert, Véronique Megalizzi, Abdalkarim Tanina, René Wintjens, Rudy Antoine, Priscille Brodin, Vincent Delorme, Martin Moune, Kamel Djaout, Stéphanie Slupek, Christian Kemmer, Marc Gitzinger, Lluis Ballell, Alfonso Mendoza-Losana, Sergio Lociuro, Benoit Deprez, David Barros-Aguirre, Modesto J. Remuiñán, Nicolas Willand, Alain R. Baulard
Publikováno v:
Science Translational Medicine. 14
The sensitivity of Mycobacterium tuberculosis , the pathogen that causes tuberculosis (TB), to antibiotic prodrugs is dependent on the efficacy of the activation process that transforms the prodrugs into their active antibacterial moieties. Various o