Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sonja Gebhard"'
Autor:
Florian Brandes, Agnes S. Meidert, Benedikt Kirchner, Mia Yu, Sonja Gebhardt, Ortrud K. Steinlein, Michael E. Dolch, Barbara Rantner, Nikolaos Tsilimparis, Gustav Schelling, Michael W. Pfaffl, Marlene Reithmair
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundAtherosclerosis is a widespread disorder of the cardiovascular system. The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks.
Externí odkaz:
https://doaj.org/article/439e49051ed847a6962a19f5a7b7e732
Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation
Autor:
Britta Schlund, Sonja Gebhard, Takako Hattori, Andreas Hess, Klaus von der Mark, Svitlana Golovchenko, Christine Hartmann, Matthias Gebhardt, Friederike Pausch
Publikováno v:
Bone. 55:102-112
In order to elucidate the role of β-catenin in hypertrophic cartilage zone of the growth plate, we deleted the β-catenin gene ctnnb1 specifically from hypertrophic chondrocytes by mating ctnnb1 fl/fl mice with BAC-Col10a1-Cre -deleter mice. Surp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4681be9c1a5352db237ec00efc74e2b0
https://doi.org/10.1016/j.bone.2013.03.019
https://doi.org/10.1016/j.bone.2013.03.019
Autor:
Michael R. Bösl, Benoit de Crombrugghe, Eva Bauer, Helga von der Mark, Britta Schlund, Takako Hattori, Sonja Gebhard, Cordula Surmann-Schmitt, Andreas Hess, Friederike Pausch, Catharina Müller, Klaus von der Mark
Publikováno v:
Development. 137:901-911
SOX9 is a transcription factor of the SRY family that regulates sex determination, cartilage development and numerous other developmental events. In the foetal growth plate, Sox9 is highly expressed in chondrocytes of the proliferating and prehypertr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6789494b8d767c12ac4b603662cd0a
https://doi.org/10.1242/dev.045203
https://doi.org/10.1242/dev.045203
Autor:
Michael R. Bösl, Takako Hattori, Klaus von der Mark, Britta Schlund, Eva Bauer, Benoit de Crombrugghe, Sonja Gebhard
Publikováno v:
Matrix Biology. 27:693-699
Previously we have shown that insertion of a LacZ reporter gene into the Col10a1 gene in the context of a bacterial artificial chromosome (BAC) drives strong and specific expression of LacZ in hypertrophic cartilage of transgenic mice [Gebhard S., Ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c3eed2168d73297d39f5601d6f24c3
https://doi.org/10.1016/j.matbio.2008.07.001
https://doi.org/10.1016/j.matbio.2008.07.001
Autor:
Nadia Adam, Klaus von der Mark, Eva Bauer, Britta Schlund, Benoit de Crombrugghe, Ernst Pöschl, Takako Hattori, Sonja Gebhard, Michael R. Bösl
Publikováno v:
Histochemistry and Cell Biology
During endochondral ossification hypertrophic chondrocytes in the growth plate of fetal long bones, ribs and vertebrae play a key role in preparing growth plate cartilage for replacement by bone. In order to establish a reporter gene mouse to facilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3e183f37917b3cb3fafe03315bca7d1
https://doi.org/10.1007/s00418-006-0236-8
https://doi.org/10.1007/s00418-006-0236-8
Autor:
Sonja Gebhard, Takako Hattori, Veronique H. L. Lefebvre, Silvia Riemer, Benoit de Crombrugghe, Heidi Eberspaecher, Ernst Pöschl, Klaus von der Mark, Zhaoping Zhang, Eva Bauer
Publikováno v:
Matrix Biology. 23:309-322
Previously we have identified a cis-acting regulatory domain in the human type X collagen gene upstream of the transcription start site which acts as a strong enhancer in hypertrophic, but not in resting chondrocytes. Here we show that this enhancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cc5e9b7a67633d8345a0cf60e1e078
https://doi.org/10.1016/j.matbio.2004.05.010
https://doi.org/10.1016/j.matbio.2004.05.010
Publikováno v:
Stiftung&Sponsoring.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df1142ff932d884f6851f733bb223490
https://doi.org/10.37307/j.2366-2913.2013.06.18
https://doi.org/10.37307/j.2366-2913.2013.06.18
Publikováno v:
Journal of cellular biochemistry. 86(4)
PTH and PTHrP have been shown to inhibit maturation of growth plate chondrocytes and the expression of type X collagen. In order to examine the regulatory mechanisms involved, fetal bovine growth plate chondrocytes were incubated for 24-48 h under se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8345a7ab6c505dbdc07b1f26ba440918
https://pubmed.ncbi.nlm.nih.gov/12210735
https://pubmed.ncbi.nlm.nih.gov/12210735