Reduction in Left Ventricular Messenger RNA for Transforming Growth Factor β 1 Attenuates Left Ventricular Fibrosis and Improves Survival Without Lowering Blood Pressure in the Hypertensive TGR(mRen2)27 Rat

Autor: Peter Kossmehl, Roland Lauster, Sara-Joan Pinto-Sietsma, Hans-Joachim Merker, Svenja Sethmann, Yigal M. Pinto, Sonja Engler, Martin Paul, Berthold Hocher, Tobias Philipp, Heike Marquardt

Publikováno v: Hypertension, 36(5), 747-754. Lippincott Williams and Wilkins
Hypertension, 36(5), 747-754. LIPPINCOTT WILLIAMS & WILKINS

Abstract —Angiotensin II recruits transforming growth factor β 1 (TGFβ 1 ) and is related to left ventricular fibrosis. However, it is unclear whether chronic in vivo reduction in left ventricular TGFβ 1 expression blunts fibrosis and improves o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c15235c283b42dade7dbac1276c945
https://doi.org/10.1161/01.hyp.36.5.747