Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sonja E. Di Gregorio"'
'Prion-like' seeding and propagation of oligomeric protein assemblies in neurodegenerative disorders
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Intra- or extracellular aggregates of proteins are central pathogenic features in most neurodegenerative disorders. The accumulation of such proteins in diseased brains is believed to be the end-stage of a stepwise aggregation of misfolded monomers t
Externí odkaz:
https://doaj.org/article/c1e48e850d5b47848ab565dc12d52b9e
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
In the past two decades, yeast models have delivered profound insights into basic mechanisms of protein misfolding and the dysfunction of key cellular pathways associated with amyotrophic lateral sclerosis (ALS). Expressing ALS-associated proteins, s
Externí odkaz:
https://doaj.org/article/ccb69c1bceb54e3b8ecc57a84cad8a2b
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5597 (2020)
The Rho guanine nucleotide exchange factor (RGNEF) protein encoded by the ARHGEF28 gene has been implicated in the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Biochemical and pathological studies have shown that RGNEF is a componen
Externí odkaz:
https://doaj.org/article/0bfcdea214e945e7a449eba58a2236d1
Autor:
Marilene H. Lopes, Lilian Tsai-Wei Lin, Marco A. M. Prado, Abdul Razzaq, Soojie Hong, Martin L. Duennwald, Brendan Charles, Flavio H. Beraldo, Sonja E. Di Gregorio, Vania F. Prado
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Protein misfolding is a central feature of most neurodegenerative diseases. Molecular chaperones can modulate the toxicity associated with protein misfolding, but it remains elusive which molecular chaperones and co-chaperones interact with specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc91e78995ebfef9eb2e05f878979c0
Autor:
Abdul Razzaq, Marilene H. Lopes, Lilian Tsai-Wei Lin, Brendan Charles, Sonja E. Di Gregorio, Marco A. M. Prado, Martin L. Duennwald, Vania F. Prado, Flavio H. Beraldo, Soojie Hong
Protein misfolding is a central feature of most neurodegenerative diseases. Molecular chaperones can modulate the toxicity associated with protein misfolding, but it remains elusive which molecular chaperones and co-chaperones interact with specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e8f212c2bf993f69e3a373110c2b3a
https://doi.org/10.1101/2020.10.08.331173
https://doi.org/10.1101/2020.10.08.331173
Autor:
Gary S. Shaw, Mohammad A. Esmaeili, Alexander S. McCarton, Susanne Schmid, Martin L. Duennwald, Taylor V. Roebotham, Sonja E. Di Gregorio, Cleusa V.R. de Oliveira, Asit Rai, Jane R. Rylett
Background: Excess oxidative stress and protein misfolding are major hallmarks of neurodegenerative disease, including Parkinson’s disease (PD). Mutations in the genes encoding the ubiquitin ligase parkin cause autosomal recessive juvenile forms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06457e519f7030581ba9bfb21fbe09e8
https://doi.org/10.21203/rs.3.rs-33898/v1
https://doi.org/10.21203/rs.3.rs-33898/v1
Publikováno v:
Anatomy and Cell Biology Publications
For the investigation of protein localization and trafficking using live cell imaging, researchers often rely on fusing their protein of interest to a fluorescent reporter. The constantly evolving list of genetically encoded fluorescent proteins (FPs
Publikováno v:
FEMS Yeast Research. 18
Yeast models of neurodegenerative diseases associated with protein misfolding and protein aggregation have given unique insights into the underlying genetic and cellular pathomechanisms. These yeast models recapitulate central aspects of protein misf
Publikováno v:
Traffic (Copenhagen, Denmark). 18(1)
The palette of fluorescent proteins (FPs) available for live-cell imaging contains proteins that strongly differ in their biophysical properties. FPs cannot be assumed to be equivalent and in certain cases could significantly perturb the behavior of
Autor:
Sarah R, Chadwick, Athanasios D, Pananos, Sonja E, Di Gregorio, Anna E, Park, Parnian, Etedali-Zadeh, Martin L, Duennwald, Patrick, Lajoie
Publikováno v:
Traffic (Copenhagen, Denmark). 17(6)
Saccharomyces cerevisiae is a well-established model organism to study the mechanisms of longevity. One of the two aging paradigms studied in yeast is termed chronological lifespan (CLS). CLS is defined by the amount of time non-dividing yeast cells