Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Sonja C. S. Simon"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Mutations in the NRAS gene are common alterations in malignant melanoma. However, there are no specific treatment options approved for NRAS-mutated melanoma patients besides immune checkpoint inhibition. Since preclinical data suggests a synergistic
Externí odkaz:
https://doaj.org/article/b1bd112b400144c08b8558480e671f81
Autor:
Vera Petrova, Christopher Groth, Rebekka Bitsch, Ihor Arkhypov, Sonja C. S. Simon, Svetlana Hetjens, Verena Müller, Jochen Utikal, Viktor Umansky
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
PurposeAlthough the treatment of advanced melanoma patients with immune checkpoint inhibitors (ICI) significantly increased the therapeutic efficiency, many patients remain resistant to ICI that could be due to immunosuppression mediated by myeloid-d
Externí odkaz:
https://doaj.org/article/d324c9c8d3714b6ab00406112a75e99a
Autor:
Sonja C. S. Simon, Xiaoying Hu, Jasper Panten, Mareike Grees, Simon Renders, Daniel Thomas, Rebekka Weber, Torsten J. Schulze, Jochen Utikal, Viktor Umansky
Publikováno v:
OncoImmunology, Vol 9, Iss 1 (2020)
Eosinophils have been identified as a prognostic marker in immunotherapy of melanoma and suggested to contribute to anti-tumor host defense. However, the influence of immune checkpoint inhibitors (ICI) on the eosinophil population is poorly studied.
Externí odkaz:
https://doaj.org/article/929050eefb31430384cff2eee14ffd5e
Autor:
Sonja C. S. Simon, Jochen Utikal
Publikováno v:
best practice onkologie. 16:308-314
Mit der Einfuhrung der zielgerichteten Therapie und der Immuntherapie hat fur das maligne Melanom ein neues Zeitalter begonnen. Nicht nur im fernmetastasierten Stadium, sondern auch fur Patienten mit lokoregionar ausgebreitetem Melanom haben sich die
Autor:
Mirko Gries, Jochen Utikal, Raphael Reinhard, Rebekka Weber, Tim Holland-Letz, Viktor Umansky, Christoffer Gebhardt, Sonja C. S. Simon, Dong Hun Mun
Publikováno v:
Cellular Immunology. 360:104274
The low dose application of chemotherapeutic agents such as paclitaxel was previously shown to initiate anti-tumor activity by neutralizing myeloid-derived suppressor cells (MDSCs) in melanoma mouse models. Here, we investigated immunomodulating effe
Publikováno v:
Cancer immunology, immunotherapy : CII. 68(5)
Eosinophils are a subset of granulocytes mostly known for their ability to combat parasites and induce allergy. Although they were described to be related to cancer more than 100 years ago, their role in tumors is still undefined. Recent observations