Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Sonja Beken"'
Autor:
R. Roggeband, Marco Corvaro, Hans Bender, D. A. Basketter, Jim Bridges, F. Lamplmair, Boris P. Müller, Silvia Casati, A. Irizar, Petra S. Kern, Laura H. Rossi, Sonja Beken, S. Cuvellier, Irene Manou, Miriam N. Jacobs, Bruno Hubesch
Publikováno v:
Regulatory Toxicology and Pharmacology. 117:104767
Skin sensitising substances that induce contact allergy and consequently risk elicitation of allergic contact dermatitis (ACD) remain an important focus regarding the replacement of animal experimentation. Current in vivo methods, notably the local l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756d009ccbb8ea03d5439bb75b4bc886
https://doi.org/10.1016/j.yrtph.2020.104767
https://doi.org/10.1016/j.yrtph.2020.104767
Autor:
Keith Jones, Michael K. Pugsley, Helen Booler, Wendy Roosen, Aidan McGuire, Jacques Richard, David Jones, Noel Downes, Ruth A. Roberts, Ankie Schoenmakers, Mark Holbrook, Andreas Rothfuss, Julia Hui, Paul Brown, Marjorie A. Peraza, S.G. Moesgaard, Helen Prior, Sonja Beken, Meghan Flaherty, Leigh Ann Burns-Naas, Ian Kimber, Melissa Chapman, Lolke de Haan, Olaf Doehr, Richard J. Weaver, Paul Brooker, Nichola Gellatly, Brian Burlinson, Elisabeth Mortimer-Cassen, Hilla Kedar, Nancy Bower, Lucinda Weir, Andreas Mahl, Alison Wolfreys, Jennifer Harris, Alli Manninen, David W. Clarke, Warren Casey, Paul Baldrick, Fiona Sewell
Publikováno v:
Regulatory Toxicology and Pharmacology. 113:104624
An international expert working group representing 37 organisations (pharmaceutical/biotechnology companies, contract research organisations, academic institutions and regulatory bodies) collaborated in a data sharing exercise to evaluate the utility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64937b1a362ed5fb5c52709a1d9219f
https://doi.org/10.1016/j.yrtph.2020.104624
https://doi.org/10.1016/j.yrtph.2020.104624
Publikováno v:
Regulatory Toxicology and Pharmacology. 73:361-366
Cancer presents a major healthcare challenge worldwide, with several millions new cases a year, and represents a therapeutic area with a high need for new drugs. To respond to this, the parties of the International Conference for Harmonization agreed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049bc31199bc8ec2b7b5cd0600b8a67a
https://doi.org/10.1016/j.yrtph.2015.07.022
https://doi.org/10.1016/j.yrtph.2015.07.022
Autor:
Sonja Beken, Brian P. Enright, William J. Breslin, Jan Willem van der Laan, Christine L E Siezen, Gregg D. Cappon, Dinesh Stanislaus, Gerhard F. Weinbauer, Peter T. Theunissen, Jennifer E. Foreman, Connie L. Chen, Sandra L. Wood, Luc De Schaepdrijver, Gary W. Chmielewski, Aldert H. Piersma, Belen Tornesi, Jane Stewart, Kok-Wah Hew, Kary E. Thompson, Matthew T. Martin, Wafa Harrouk, Susan B. Laffan, Bruce K. Beyer, Alan M. Hoberman, Thomas B. Knudsen, Julia Y. Hui, Mary Ellen McNerney, Susan L. Makris
Publikováno v:
Critical reviews in toxicology. 46(10)
Regulatory non-clinical safety testing of human pharmaceuticals typically requires embryo-fetal developmental toxicity (EFDT) testing in two species (one rodent and one non-rodent). The question has been raised whether under some conditions EFDT test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4707b0dd83d27eec8d13b127ccb7c29d
https://pubmed.ncbi.nlm.nih.gov/27848393
https://pubmed.ncbi.nlm.nih.gov/27848393
Publikováno v:
Advances in experimental medicine and biology. 856
Animal studies may be carried out to support first administration of a new medicinal product to either humans or the target animal species, or before performing clinical trials in even larger populations, or before marketing authorisation, or to cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::980ac022dd247d4e8f6a3a7cb27fa669
https://pubmed.ncbi.nlm.nih.gov/27671719
https://pubmed.ncbi.nlm.nih.gov/27671719
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783319338248
Animal studies may be carried out to support first administration of a new medicinal product to either humans or the target animal species, or before performing clinical trials in even larger populations, or before marketing authorisation, or to cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e39cb2fdd6f204656e1c6ac6f43132d8
https://doi.org/10.1007/978-3-319-33826-2_3
https://doi.org/10.1007/978-3-319-33826-2_3
Autor:
Irene Manou, Sandra De Jonghe, Annette Mehling, Jan van Benthem, Sonja Beken, Renate Weissenhorn, Tzutzuy Ramirez, Magda Chlebus, Laura H. Rossi, Kerstin Reisinger, Jan Willem van der Laan, Graham Ellis, Claudius Griesinger, Ursula G. Sauer
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 73(1)
The European Partnership for Alternative Approaches to Animal Testing (EPAA) convened a workshop Knowledge sharing to facilitate regulatory decision-making. Fifty invited participants from the European Commission, national and European agencies and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b5b1af03705e674672823b26de002d
https://pubmed.ncbi.nlm.nih.gov/26188116
https://pubmed.ncbi.nlm.nih.gov/26188116
Autor:
Karen De Smet, Tracy Walker, Sonja Beken, Frank Roels, Ingrid Kerckaert, Marianne Depreter, Vera Rogiers
Publikováno v:
The Histochemical Journal. 34:139-151
In search of factors that regulate the phenotype of the peroxisomal compartment in wild-type liver parenchymal cells, we compared hepatocyte polarity to peroxisome differentiation, using adult liver as the standard. Differentiation parameters were ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e19465bfcbbdce8319b11becd5d1cc17
https://doi.org/10.1023/a:1020990414190
https://doi.org/10.1023/a:1020990414190
Autor:
Sonja Beken, Olivier Toussaint, Valentine Minet, Lütfiye Alpan, François Mullier, Julie Laloy, Stéphane Lucas, Jean-Michel Dogné
Publikováno v:
Nanobiomedicine, Vol 1 (2014)
Nanobiomedicine
Volume 1
Issue Godište 2014
Nanobiomedicine, Vol 1, Iss, p 4 (2014)
Nanobiomedicine
Volume 1
Issue Godište 2014
Nanobiomedicine, Vol 1, Iss, p 4 (2014)
Silver nanoparticles (Ag NPs) are increasingly used in biomedical applications because of their large antimicrobial spectrum. Data in the literature on the ability of Ag NPs to perform their desired function without eliciting undesirable effects on b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7440c7c2f90dfa9b89d1cd097bb41c52
https://doaj.org/article/68855ddef3f74b5386c4cf423b7effb5
https://doaj.org/article/68855ddef3f74b5386c4cf423b7effb5
Autor:
Thomas Brüning, Evert H. Delbanco, Ricarda Thier, Frank H. Brands, Frank Geller, Sonja Beken, S. Philippou, Wolfgang W. Huber, Hermann M. Bolt
Publikováno v:
Archives of Toxicology. 74:688-694
In general, the biological activation of nephrocarcinogenic chlorinated hydrocarbons proceeds via conjugation with glutathione. It has mostly been assumed that the main site of initial conjugation is the liver, followed by a mandatory transfer of int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2673264f25beace1600967e8175a2334
https://doi.org/10.1007/s002040000184
https://doi.org/10.1007/s002040000184