Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sonja Baumli"'
Autor:
Justyna Zaborowska, Sonja Baumli, Clelia Laitem, Dawn O'Reilly, Peter H Thomas, Peter O'Hare, Shona Murphy
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107654 (2014)
The Herpes Simplex Virus 1 (HSV-1)-encoded ICP22 protein plays an important role in viral infection and affects expression of host cell genes. ICP22 is known to reduce the global level of serine (Ser)2 phosphorylation of the Tyr1Ser2Pro3Thr4Ser5Pro6S
Externí odkaz:
https://doaj.org/article/71329b1d26934147a9882c5d8479d841
Autor:
Michael Meisterernst, André Mourão, Michael Sattler, Laurent Larivière, Sonja Baumli, Patrick Cramer, Bernd Simon, Erika Vojnic, Karen Baumgart, Larissa Wenzeck, Martin Seizl
Publikováno v:
Nature Structural and Molecular Biology
Eukaryotic transcription is regulated by interactions between gene-specific activators and the coactivator complex Mediator. Here we report the NMR structure of the Mediator subunit Med25 (also called Arc92) activator interaction domain (ACID) and an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c357208889bac4c26a7d9e9c276966
https://doi.org/10.1038/nsmb.1997
https://doi.org/10.1038/nsmb.1997
Publikováno v:
Chemistry & Biology. 17:931-936
SummaryCdk9, the kinase of the positive transcription elongation factor b, is required for processive transcription elongation by RNA polymerase II. Cdk9 inhibition contributes to the anticancer activity of many Cdk inhibitors under clinical investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30f53a63150a7ac75297d883d8c5e6c
https://doi.org/10.1016/j.chembiol.2010.07.012
https://doi.org/10.1016/j.chembiol.2010.07.012
Autor:
Sonja Baumli, Hervé Galons, Sétha Douc-Rasy, Jane A. Endicott, Alison J. Hole, Jean Bénard, Nassima Oumata, Laurent Meijer, Dianne Baunbæk, Nadège Loaëc, Claire Delehouzé, Karima Bettayeb
Publikováno v:
Genes & Cancer. 1:369-380
Neuroblastoma (NB), the most frequent extracranial solid tumor of children accounting for nearly 15% of all childhood cancer mortality, displays overexpression of antiapoptotic Bcl-2 and Mcl-1 in aggressive forms of the disease. The clinical phase 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5acf6726d41283b3bc5f295c1cf39578
https://doi.org/10.1177/1947601910369817
https://doi.org/10.1177/1947601910369817
Autor:
Sonja Baumli, Karim-Jean Armache, Patrick Cramer, Alessandro Vannini, Claudia Buchen, Kristin Leike, Anja J. Jasiak, Sebastian R. Geiger, Hubert Kettenberger, Florian Brueckner, Elisabeth Lehmann, Claus-D. Kuhn, Gerke E. Damsma, Stefan Jennebach, Tomislav Kamenski, Stefan Benkert, Jasmin F. Sydow, Anass Jawhari, Stefan Dengl
Publikováno v:
Annual Reviews of Biophysics
The eukaryotic RNA polymerases Pol I, Pol II, and Pol III are the central multiprotein machines that synthesize ribosomal, messenger, and transfer RNA, respectively. Here we provide a catalog of available structural information for these three enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a8bb2e212e44c64deb7cbb25d7be30
https://doi.org/10.1146/annurev.biophys.37.032807.130008
https://doi.org/10.1146/annurev.biophys.37.032807.130008
Publikováno v:
Journal of Molecular Biology
Cyclin C binds the cyclin-dependent kinases CDK8 and CDK3, which regulate mRNA transcription and the cell cycle, respectively. The crystal structure of cyclin C reveals two canonical five-helix repeats and a specific N-terminal helix. In contrast to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61dc18892ff446336dda27f782c29791
https://doi.org/10.1016/j.jmb.2005.05.041
https://doi.org/10.1016/j.jmb.2005.05.041
Publikováno v:
Genes and Development
The C-terminal domain (CTD) of RNA polymerase II (Pol II) integrates nuclear events by binding proteins involved in mRNA biogenesis. CTD-binding proteins recognize a specific CTD phosphorylation pattern, which changes during the transcription cycle,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0688f8030dff4acb51c66b6e1ed638
https://doi.org/10.1101/gad.1318105
https://doi.org/10.1101/gad.1318105
Autor:
Jane A. Endicott, Chris Pepper, Alison J. Hole, Abdullahi Y. Abbas, Shenhua Shi, Frankie Lam, Shudong Wang, Martin E.M. Noble, Sonja Baumli, Hao Shao, Xiangrui Liu, David W. Foley, Shiliang Huang, Peter Fischer
Publikováno v:
Journal of Medicinal Chemistry
Cancer cells often have a high demand for antiapoptotic proteins in order to resist programmed cell death. CDK9 inhibition selectively targets survival proteins and reinstates apoptosis in cancer cells. We designed a series of 4-thiazol-2- anilinopyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ca38616b46173ee2f7407ba2de20a5
https://pubmed.ncbi.nlm.nih.gov/23301767
https://pubmed.ncbi.nlm.nih.gov/23301767
Publikováno v:
Structure(London, England:1993)
Summary CDK9, the kinase of positive transcription elongation factor b (P-TEFb), stimulates transcription elongation by phosphorylating RNA polymerase II and transcription elongation factors. Using kinetic analysis of a human P-TEFb complex consistin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1de88ebff222c5345305964056be0be
https://pubmed.ncbi.nlm.nih.gov/22959624
https://pubmed.ncbi.nlm.nih.gov/22959624
Publikováno v:
ACS Chemical Biology
CDK9 is the kinase of positive transcription elongation factor b and facilitates the transition of paused RNA polymerase II to processive transcription elongation. CDK9 is a validated target for the treatment of cancer, cardiac hypertrophy, and human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32256a576448f87f369ca291392c0182
https://pubmed.ncbi.nlm.nih.gov/22292676
https://pubmed.ncbi.nlm.nih.gov/22292676