Výsledky vyhledávání - "Sonia Trépanier"

Akademický článek

Safety and immunogenicity of an AS03-adjuvanted plant-based SARS-CoV-2 vaccine in Adults with and without Comorbidities

Publikováno v: npj Vaccines, Vol 7, Iss 1, Pp 1-13 (2022)

Abstract The rapid spread of SARS-CoV-2 continues to impact humanity on a global scale with rising total morbidity and mortality. Despite the development of several effective vaccines, new products are needed to supply ongoing demand and to fight var

Externí odkaz: https://doaj.org/article/b6a4cc5cfcb64d00803666e2639e3ffb

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Akademický článek

Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate-Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults.

Autor: Stéphane Pillet, Julie Couillard, Sonia Trépanier, Jean-François Poulin, Bader Yassine-Diab, Bruno Guy, Brian J Ward, Nathalie Landry

Publikováno v: PLoS ONE, Vol 14, Iss 6, p e0216533 (2019)

BackgroundNew influenza vaccines eliciting more effective protection are needed, particularly for the elderly who paid a large and disproportional toll of hospitalization and dead during seasonal influenza epidemics. Low (≤15 μg/strain) doses of a

Externí odkaz: https://doaj.org/article/a789952e30b74c05bda27af751e8842f

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Akademický článek

Preclinical and clinical development of plant-made virus-like particle vaccine against avian H5N1 influenza.

Autor: Nathalie Landry, Brian J Ward, Sonia Trépanier, Emanuele Montomoli, Michèle Dargis, Giulia Lapini, Louis-P Vézina

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15559 (2010)

UnlabelledThe recent swine H1N1 influenza outbreak demonstrated that egg-based vaccine manufacturing has an Achille's heel: its inability to provide a large number of doses quickly. Using a novel manufacturing platform based on transient expression o

Externí odkaz: https://doaj.org/article/ca8e93613f84474b8fe3ee1da465d892

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Lack of effects on female fertility or pre- and postnatal development of offspring in rats after exposure to AS03-adjuvanted recombinant plant-derived virus-like particle vaccine candidate for COVID-19

Autor: Eric Destexhe, Sarah Paris-Robidas, Charlotte Dubé, Nathalie Landry, Sonia Trépanier, Iryna Primakova, Brian J. Ward

Publikováno v: Reproductive Toxicology (Elmsford, N.y.)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection resulting in the coronavirus disease 2019 (COVID-19) has afflicted tens of millions of people in a worldwide pandemic. A recently developed recombinant Plant-Derived Virus-Like Pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf32aa4c40e95ebded16735f4c91d8cb
http://europepmc.org/articles/PMC8611889

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Safety and immunogenicity of a plant-derived rotavirus-like particle vaccine in adults, toddlers and infants

Autor: Sonia Trépanier, Michèle Dargis, Monica M. McNeal, Yutaka Kawaguchi, Michelle K. Robinson, Yoshito Koujin, Manon Couture, Catherine Bernard, Shabir A. Madhi, Bruce D. Forrest, Anthonet Koen, Natsuki Kurokawa, Naohisa Tsutsui, Thomas M. Polasek

Publikováno v: Vaccine. 39:5513-5523

Background This study is the first clinical trial for a parenteral non-replicating rotavirus vaccine developed using virus-like particle (VLP) technology. Methods This open-labeled, randomized, placebo-controlled trial was conducted in two parts: Par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed67386d3a647f5a8d73fe260af507c
https://doi.org/10.1016/j.vaccine.2021.08.052

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Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19

Autor: Karen Hager, Nathalie Landry, Pierre-Yves Charbonneau, Matthew P. Cheng, Marc-André D'Aoust, Alexander I. Makarkov, Judith Atkins, Asif Mahmood, Carolyn Finkle, Stéphane Pillet, Manon Couture, Iohann Boulay, Patricia Schimke, Annie Séguin, Sylvie St-Martin, Brian J. Ward, Jiwanjeet Dhaliwall, Philipe Gobeil, Sonia Trépanier

Publikováno v: Nature Medicine

Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are being deployed, but the global need greatly exceeds the supply, and different formulations might be required for specific populations. Here we report Day 42 interim saf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeef6537059b51258cd42e52027595d5
http://europepmc.org/articles/PMC8205852

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Phase III: Randomized observer-blind trial to evaluate lot-to-lot consistency of a new plant-derived quadrivalent virus like particle influenza vaccine in adults 18–49 years of age

Autor: Sonia Trépanier, Julie Couillard, Brian J. Ward, Nathalie Landry, Annie Séguin

Publikováno v: Vaccine. 39:1528-1533

Background The global reliance on eggs to produce most influenza vaccines has several limitations and new approaches to influenza vaccine production are needed. Herein we describe a phase 3, lot-to-lot consistency trial (NCT03321968) of a quadrivalen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb62b1ab37b523c330d9b7ad78cb408
https://doi.org/10.1016/j.vaccine.2021.01.004

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Efficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18–64 years) and older adults (≥65 years): two multicentre, randomised phase 3 trials

Autor: Alexander I. Makarkov, Stéphane Pillet, Michael Libman, Nathalie Landry, Annie Séguin, Brian J. Ward, Jiwanjeet Dhaliwall, Sonia Trépanier, Timo Vesikari

Publikováno v: The Lancet. 396:1491-1503

Summary Background Seasonal influenza remains a substantial public health threat despite the availability of egg-derived and other vaccines. Plant-based manufacturing might address some of the limitations of current vaccines. We describe two phase 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76df5e372a7ab5a7f58b812e0c2fa57a
https://doi.org/10.1016/s0140-6736(20)32014-6

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Broad neutralization against SARS-CoV-2 variants induced by ancestral and B.1.351 AS03-Adjuvanted recombinant Plant-Derived Virus-Like particle vaccines

Autor: Charlotte Dubé, Sarah Paris-Robidas, Guadalupe Andreani, Cindy Gutzeit, Marc-André D'Aoust, Brian J. Ward, Sonia Trépanier

Publikováno v: Vaccine. 40(30)

Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection resulting in the coronavirus disease 2019 (COVID-19) has afflicted hundreds of millions of people in a worldwide pandemic. Several safe and effective COVID-19 vaccines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6acae2dde0b427fbdecd650d54ed9b87
https://pubmed.ncbi.nlm.nih.gov/35654621

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