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Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration
Autor:
Jasmina Zivanovic, Sonia Schott-Roux, James R. Mitchell, Bikash Adhikari, Biljana Bursac, Guenter Schwarz, Jan Lj. Miljkovic, Sarah J. Mitchell, Bindu D. Paul, Daniel Thomas-Lopez, Milos R. Filipovic, Ivana Ivanović-Burmazović, Moran Benhar, Joshua B. Kohl, Roberta Torregrossa, José-Eduardo Gomes, Solomon H. Snyder, Bruno Gonzalez-Zorn, Kate S. Carroll, Matthew Whiteman, Verica Milošević, Youngeun Jung, Marko Miler, Emilia Kouroussis, Dunja Petrovic
Publikováno v:
Cell Metab
Cell Metabolism
Cell Metabolism, Elsevier, 2019, 30, pp.1152-1170.e13. ⟨10.1016/j.cmet.2019.10.007⟩
Cell Metabolism
Cell Metabolism, Elsevier, 2019, 30, pp.1152-1170.e13. ⟨10.1016/j.cmet.2019.10.007⟩
Summary Life on Earth emerged in a hydrogen sulfide (H2S)-rich environment eons ago and with it protein persulfidation mediated by H2S evolved as a signaling mechanism. Protein persulfidation (S-sulfhydration) is a post-translational modification of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5fa8c7df85425ffabdccc1dfc9a546
https://europepmc.org/articles/PMC7249486/
https://europepmc.org/articles/PMC7249486/
Publikováno v:
Free Radical Biology and Medicine. 112:187-188
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of cysteine residues (RSH) to persulfides (RSSH), and provides a framework for understanding its physiological and pharmacological effects. Due to the inherent