Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Sonia R. Miranda"'
Publikováno v:
Molecules, Vol 22, Iss 1, p 142 (2017)
Silymarin is the most commonly used herbal medicine by patients with chronic liver disease. Silymarin flavonolignans undergo rapid first-pass metabolism primarily by glucuronidation. The aims of this investigation were: (1) to determine the associati
Externí odkaz:
https://doaj.org/article/15b92a8626c3440e914d7a5e7d535b4e
Autor:
Jun Tang, Kevin W. Brown, Jerry Jeffrey, Charlene B. McDanal, Brian A. Johns, Sonia R. Miranda, Stacey A. Jones, David M. Irlbeck, Cristin M. Galardi
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(12)
A new class of betulin-derived α-keto amides was identified as HIV-1 maturation inhibitors. Through lead optimization, GSK8999 was identified with IC50 values of 17 nM, 23 nM, 25 nM, and 8 nM for wild type, Q369H, V370A, and T371A respectively. When
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218669177b08ef6a1fe9d91139f48e57
https://pubmed.ncbi.nlm.nih.gov/28454672
https://pubmed.ncbi.nlm.nih.gov/28454672
Publikováno v:
Molecules, Vol 22, Iss 1, p 142 (2017)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 22; Issue 1; Pages: 142
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 22; Issue 1; Pages: 142
Silymarin is the most commonly used herbal medicine by patients with chronic liver disease. Silymarin flavonolignans undergo rapid first-pass metabolism primarily by glucuronidation. The aims of this investigation were: (1) to determine the associati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ddfc1d5d8444df04884b7cce171e8eb
http://www.mdpi.com/1420-3049/22/1/142
http://www.mdpi.com/1420-3049/22/1/142
Autor:
Jun Tang, Erjuan Wang, Zhimin Jin, Kevin W. Brown, David M. Irlbeck, Jerry L. Jeffery, Rui Li, Heping Yang, Cristin M. Galardi, Sonia R. Miranda, Bin Shen, Charlene B. McDanal, Yajun Yu, Daxin Gao, Brian A. Johns, Chunyu Liu, Yongyong Wu, Yufei Sun, Caiming Xi, Nianhe Han, Stacey A. Jones
Publikováno v:
The Open Medicinal Chemistry Journal
A macrocycle provides diverse functionality and stereochemical complexity in a conformationally preorganized ring structure, and it occupies a unique chemical space in drug discovery. However, the synthetic challenge to access this structural class i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533b3d6198adabb5714b9d267efd4805
https://doi.org/10.2174/1874104501408010023
https://doi.org/10.2174/1874104501408010023
Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7
Autor:
Sonia R. Miranda, Sharon A. Meyer
Publikováno v:
Food and Chemical Toxicology. 45:871-877
Alachlor is cytotoxic to human hepatoblastoma HepG2s, a cell line that expresses constitutive CYP3A7 and dexamethasone (DEX)-inducible CYP3A4 and CYP3A7. CYP3A4 catalyzes alachlor N-dealkylation to 2-chloro-N-(2,6-diethylphenyl)acetamide (CDEPA), pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3e9f771d215a7994175cd21b0e86bb
https://doi.org/10.1016/j.fct.2006.11.011
https://doi.org/10.1016/j.fct.2006.11.011
Autor:
Brian A. Johns, Emile Johann Velthuisen, Kendra E. Hightower, John W. Seal, Peter Gerondelis, Kevin K. Brown, Ming Li, Lisa A. Leesnitzer, Wenwen Zhang, Yan Chen, Sonia R. Miranda, Ke Mou
Publikováno v:
European journal of medicinal chemistry. 83
Using a structure based pharmacophore design, a weak inhibitor of RNase H, identified from a small library of two metal binding HIV-1 integrase inhibitors, was optimized for potency and physicochemical properties. This manuscript describes the SAR an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bd973f72221ddfffa959c04284f6b71
https://pubmed.ncbi.nlm.nih.gov/24997293
https://pubmed.ncbi.nlm.nih.gov/24997293
Publikováno v:
Journal of biochemical and molecular toxicology. 22(1)
Noncancerous adverse effects observed at the lowest dose for chloroacetanilide herbicides alachlor [2-chloro-2',6'-diethyl-N-(methoxymethyl)-acetanilide] and acetochlor [2-chloro-2'-methyl-6'-ethyl-N-(ethoxymethyl)acetanilide], but not metolachlor [2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba755972609b5e0eda0ddd029330f8b
https://pubmed.ncbi.nlm.nih.gov/18273908
https://pubmed.ncbi.nlm.nih.gov/18273908