Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Sonia R Salvatore"'
Autor:
Marco Fazzari, Andrés Trostchansky, Francisco J Schopfer, Sonia R Salvatore, Beatriz Sánchez-Calvo, Dario Vitturi, Raquel Valderrama, Juan B Barroso, Rafael Radi, Bruce A Freeman, Homero Rubbo
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84884 (2014)
Extra virgin olive oil (EVOO) and olives, key sources of unsaturated fatty acids in the Mediterranean diet, provide health benefits to humans. Nitric oxide (•NO) and nitrite (NO2 (-))-dependent reactions of unsaturated fatty acids yield electrophil
Externí odkaz:
https://doaj.org/article/420b2b2b33494c3eaad47a584a8fb675
Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives.
Autor:
Chiara Cipollina, Sonia R Salvatore, Matthew F Muldoon, Bruce A Freeman, Francisco J Schopfer
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94836 (2014)
Dietary ω-3 polyunsaturated fatty acids (PUFAs) decrease cardiovascular risk via suppression of inflammation. The generation of electrophilic α,β-unsaturated ketone derivatives of the ω-3 PUFAs docosahexaenoic acid (DHA) and docosapentaenoic acid
Externí odkaz:
https://doaj.org/article/718d0e24d07241b5a3f63966a6dba529
Autor:
Fei Chang, Camilla Gunderstofte, Nicole Colussi, Mareena Pitts, Sonia R. Salvatore, Anne L. Thielke, Lucia Turell, Beatriz Alvarez, Raphaela Goldbach-Mansky, Luis Villacorta, Christian K. Holm, Francisco J. Schopfer, Anne Louise Hansen
Publikováno v:
Redox Biology, Vol 74, Iss , Pp 103202- (2024)
Stimulator of Interferon Genes (STING) is essential for the inflammatory response to cytosolic DNA. Despite that aberrant activation of STING is linked to an increasing number of inflammatory diseases, the development of inhibitors has been challengi
Externí odkaz:
https://doaj.org/article/cf3a9eefd90d46eca97eb23c61fe9d7d
Autor:
Lisa Hong, Dennis C. Braden, Yaoning Zhao, John J. Skoko, Fei Chang, Steven R. Woodcock, Crystall Uvalle, Allison Casey, Katherine Wood, Sonia R. Salvatore, Alparslan Asan, Trey Harkness, Adeola Fagunloye, Mortezaali Razzaghi, Adam Straub, Maria Spies, Daniel D. Brown, Adrian V. Lee, Francisco Schopfer, Bruce A. Freeman, Carola A. Neumann
Publikováno v:
Redox Biology, Vol 66, Iss , Pp 102856- (2023)
Nitro fatty acids (NO2-FAs) are endogenously generated lipid signaling mediators from metabolic and inflammatory reactions between conjugated diene fatty acids and nitric oxide or nitrite-derived reactive species. NO2-FAs undergo reversible Michael a
Externí odkaz:
https://doaj.org/article/74e2d4a459964b33908f0fc33cbe7493
Autor:
Marta Bueno, Jazmin Calyeca, Timur Khaliullin, Megan P. Miller, Diana Alvarez, Lorena Rosas, Judith Brands, Christian Baker, Amro Nasser, Stephanie Shulkowski, August Mathien, Nneoma Uzoukwu, John Sembrat, Brenton G. Mays, Kaitlin Fiedler, Scott A. Hahn, Sonia R. Salvatore, Francisco J. Schopfer, Mauricio Rojas, Peter Sandner, Adam C. Straub, Ana L. Mora
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Type II alveolar epithelial cell (AECII) redox imbalance contributes to the pathogenesis of idiopathic pulmonary fibrosis (IPF), a deadly disease with limited treatment options. Here, we show that expression of membrane-bound cytochrome B5 reductase
Externí odkaz:
https://doaj.org/article/c430eef5b8e94876abbd6d496306422d
Autor:
Sara E. Lewis, Lihua Li, Marco Fazzari, Sonia R. Salvatore, Jiang Li, Emily A. Hileman, Brooke A. Maxwell, Francisco J. Schopfer, Gavin E. Arteel, Nicholas K.H. Khoo, Eric E. Kelley
Publikováno v:
Advances in Redox Research, Vol 6, Iss , Pp 100051- (2022)
Recent reports have clearly demonstrated a tight correlation between obesity and elevated circulating uric acid levels (hyperuricemia). However, nearly all preclinical work in this area has been completed with male mice, leaving the field with a cons
Externí odkaz:
https://doaj.org/article/f44e15175fa74bed8879c6cb61d96b9f
Autor:
Marco Fazzari, Dario A. Vitturi, Steven R. Woodcock, Sonia R. Salvatore, Bruce A. Freeman, Francisco J. Schopfer
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 2, Pp 388-399 (2019)
Electrophilic nitro-fatty acids [NO2-FAs (fatty acid nitroalkenes)] showed beneficial signaling actions in preclinical studies and safety in phase 1 clinical trials. A detailed description of the pharmacokinetics (PK) of NO2-FAs is complicated by the
Externí odkaz:
https://doaj.org/article/b7f8eccab07f43aab87326995af65349
Autor:
Kevin G. Hicks, Ahmad A. Cluntun, Heidi L. Schubert, Sean R. Hackett, Jordan A. Berg, Paul G. Leonard, Mariana A. Ajalla Aleixo, Youjia Zhou, Alex J. Bott, Sonia R. Salvatore, Fei Chang, Aubrie Blevins, Paige Barta, Samantha Tilley, Aaron Leifer, Andrea Guzman, Ajak Arok, Sarah Fogarty, Jacob M. Winter, Hee-Chul Ahn, Karen N. Allen, Samuel Block, Iara A. Cardoso, Jianping Ding, Ingrid Dreveny, William C. Gasper, Quinn Ho, Atsushi Matsuura, Michael J. Palladino, Sabin Prajapati, Pengkai Sun, Kai Tittmann, Dean R. Tolan, Judith Unterlass, Andrew P. VanDemark, Matthew G. Vander Heiden, Bradley A. Webb, Cai-Hong Yun, Pengkai Zhao, Bei Wang, Francisco J. Schopfer, Christopher P. Hill, Maria Cristina Nonato, Florian L. Muller, James E. Cox, Jared Rutter
Publikováno v:
Science
Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352755dceffe88559d81ce00a2f38a1e
https://doi.org/10.1126/science.abm3452
https://doi.org/10.1126/science.abm3452
Autor:
Luciano M. Di Fino, Ignacio Cerrudo, Sonia R. Salvatore, Francisco J. Schopfer, Carlos García-Mata, Ana M. Laxalt
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
Nitric oxide (NO) is a second messenger that regulates a broad range of physiological processes in plants. NO-derived molecules called reactive nitrogen species (RNS) can react with unsaturated fatty acids generating nitrated fatty acids (NO2-FA). NO
Externí odkaz:
https://doaj.org/article/b8ecf7d927554b47889623b168ed34e9
Autor:
Mara Carreño, Maria F. Pires, Steven R. Woodcock, Tomasz Brzoska, Samit Ghosh, Sonia R. Salvatore, Fei Chang, Nicholas K. H. Khoo, Matthew Dunn, Nora Connors, Shuai Yuan, Adam C. Straub, Stacy G. Wendell, Gregory J. Kato, Bruce A. Freeman, Solomon F. Ofori-Acquah, Prithu Sundd, Francisco J. Schopfer, Dario A. Vitturi
Publikováno v:
Science advances. 8(26)
The up-regulation of kynurenine metabolism induces immunomodulatory responses via incompletely understood mechanisms. We report that increases in cellular and systemic kynurenine levels yield the electrophilic derivative kynurenine-carboxyketoalkene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc53acefca0e360f5b880e46faee37a0
https://pubmed.ncbi.nlm.nih.gov/35767602
https://pubmed.ncbi.nlm.nih.gov/35767602