Abnormal expression of synaptic proteins and neurotrophin-3 in the down syndrome mouse model Ts65Dn

Autor: Ausma Rabe, Virginia Gao, Gabriella Pollonini, Giorgio Albertini, Sonia Palminiello, Cristina M. Alberini

Publikováno v: Neuroscience. 156:99-106

Down syndrome (DS) results from triplication of the whole or distal part of human chromosome 21. Persons with DS suffer from deficits in learning and memory and cognitive functions in general, and, starting from early development, their brains show d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acbee6a890231fb41f43064148a518bf
https://doi.org/10.1016/j.neuroscience.2008.07.025

Form of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A nonphosphorylated at tyrosine 145 and 147 is enriched in the nuclei of astroglial cells, adult hippocampal progenitors, and some cholinergic axon terminals

Autor: Y.W. Hwang, A.A. Golabek, Ausma Rabe, M. Walus, E. Kida, Sonia Palminiello, Katarzyna Jarząbek, Giorgio Albertini

Publikováno v: Neuroscience. 195

Compelling lines of evidence indicate that overexpression of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) in subjects with trisomy 21 (Down syndrome[DS]) contributes to the abnormal structure and function of the DS brain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2efe5806f834f8a642bcd08add34be7
https://pubmed.ncbi.nlm.nih.gov/21878370

Upregulation of phosphorylated alphaB-crystallin in the brain of children and young adults with Down syndrome

Autor: Adam A. Golabek, Marius Walus, Elizabeth Kida, Kulbir Kaur, Katarzyna Jarząbek, Ausma Rabe, Giorgio Albertini, Sonia Palminiello

Publikováno v: Brain research. 1268

Our previous proteomic studies disclosed upregulation of alphaB-crystallin, a small heat shock protein, in the brain tissue of Ts65Dn mice, a mouse model for Down syndrome (DS). To validate data obtained in model animals, we studied at present the le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2c70af19af09f323e77ec35d99380e
https://pubmed.ncbi.nlm.nih.gov/19272359

Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome

Autor: Wieslaw K. Dowjat, Yu Wen Hwang, Sonia Palminiello, Krzysztof Nowicki, Izabela Kuchna, Tatyana Adayev, Jerzy Wegiel

Publikováno v: Neuroscience letters. 413(1)

Down syndrome (DS) is the most common genetic disorder associated with mental retardation (MR). It is believed that many of the phenotypic features of DS stem from enhanced expression of a set of genes located within the triplicated region on chromos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc3f06231f5346ad862de7f8dd87b44c
https://pubmed.ncbi.nlm.nih.gov/17145134

Association study of autistic disorder and chromosome 16p

Autor: Agata Fiumara, Paola Lucarelli, Maurizio Elia, Sonia Palminiello, Nunzio Bottini, Danila De Luca, Patrizia Saccucci, Paolo Curatolo

Publikováno v: 119 (2003): 242–246.
info:cnr-pdr/source/autori:Lucarelli P, Palminiello S, Saccucci P, Bottini N, De Luca D, Elia M, Fiumara A, Curatolo P./titolo:Association study of autistic disorder and chromosome 16p./doi:/rivista:/anno:2003/pagina_da:242/pagina_a:246/intervallo_pagine:242–246/volume:119

Autism is a severe neuropsychiatric disorder characterized by social and communicative impairment and repetitive stereotyped behaviors and interest. Although the etiology of autistic disorder (AD) is unknown, a complex genetic component has been stro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa33de885df428205dbcf1349839a6b
https://publications.cnr.it/doc/11370