Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sonia Pahwa"'
Autor:
Anuradha Ramamoorthy, Girish Bende, Edwin Chiu Yuen Chow, Hristina Dimova, Neil Hartman, Daphney Jean, Sonia Pahwa, Yunzhao Ren, Chinmay Shukla, Yuching Yang, Suresh Doddapaneni, Zhixia Yan Danielsen
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 11, Pp 2567-2575 (2022)
Abstract Human radiolabeled mass balance studies are an important component of the clinical pharmacology programs supporting the development of new investigational drugs. These studies allow for understanding of the absorption, distribution, metaboli
Externí odkaz:
https://doaj.org/article/6a45c2e8ac164403ad021fe10f01bcb2
Autor:
Jason N Moore, Lucas Poon, Sonia Pahwa, Timothy Bensman, Xiaohui (Tracey) Wei, Zhixia Yan Danielsen, Seong Jang
Publikováno v:
Journal of Antimicrobial Chemotherapy. 78:1337-1343
In the wake of emerging antimicrobial resistance, antibacterial drug development has become more critical. At the same time, development of antibacterial drugs targeting specific pathogens or resistance phenotypes that may have low prevalence present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45c5b0cc0b191103ac49602bbeb67aa9
https://doi.org/10.1093/jac/dkad114
https://doi.org/10.1093/jac/dkad114
Autor:
Zhichao Liu, Xi Chen, Wendy Carter, Alicia Moruf, Takashi E. Komatsu, Sonia Pahwa, Kirk Chan-Tack, Kevin Snyder, Nicholas Petrick, Kenny Cha, Madhu Lal-Nag, Qais Hatim, Shraddha Thakkar, Yu Lin, Ruili Huang, Dong Wang, Tucker A. Patterson, Weida Tong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f8a965d7ff1ef36ab3ff4ee277d2980
https://doi.org/10.1016/b978-0-12-824010-6.00005-8
https://doi.org/10.1016/b978-0-12-824010-6.00005-8
Autor:
Alex Y. Strongin, Sabrina Amar, Rafael Fridman, Manishabrata Bhowmick, Gregg B. Fields, Jian Cao, Stephen J. Weiss, Sonia Pahwa
Publikováno v:
Chem Biol Drug Des
Quantitative assessment of MT1-MMP cell surface-associated proteolytic activity remains undefined. Presently, MT1-MMP was stably expressed and a cell-based FRET assay developed to quantify activity towards synthetic collagen-model triple-helices. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a80e5c26fa4a1e0a401560b7bc7d8cbe
https://doi.org/10.1111/cbdd.13450
https://doi.org/10.1111/cbdd.13450
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 165
Organic anion transporting polypeptides (OATP)1B1 and OATP1B3 are liver-specific transport proteins that express on the basolateral membrane of human hepatocytes and mediate hepatic uptake of many drugs, including statins. They are important determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc833698aba39d5600426325f7cc45f
https://pubmed.ncbi.nlm.nih.gov/34311070
https://pubmed.ncbi.nlm.nih.gov/34311070
Autor:
Wei Yue, Khondoker Alam, Taleah Farasyn, Qiang Liu, Kai Ding, Alexandra Crowe, Sonia Pahwa, Ruhul Kayesh, Oliver Hatley, Sibylle Neuhoff
Publikováno v:
J Pharm Sci
Organic anion transporting polypeptides (OATP) 1B1 and OATP1B3 are important determinants of transporter-mediated drug-drug interactions (DDIs). Current studies assessed the OATP1B1 and OATP1B3-mediated DDI potential of vemurafenib, a kinase inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545872511e4fa8529411df0cd308674d
https://europepmc.org/articles/PMC7750294/
https://europepmc.org/articles/PMC7750294/
Autor:
Taleah Farasyn, Alexandra Crowe, Sonia Pahwa, Khondoker Alam, Kai Ding, Wei Yue, Sibylle Neuhoff, Oliver Hatley
Publikováno v:
Journal of Pharmaceutical Sciences. 106:2123-2135
Present studies determined the effects of pretreatment with rifampicin, an organic anion-transporting polypeptide (OATP) inhibitor, and the tyrosine kinase inhibitor dasatinib on OATP1B1- and OATP1B3-mediated transport, and evaluated the OATP-mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4f86a485a738e1f8268c0614a2d192d
https://doi.org/10.1016/j.xphs.2017.03.022
https://doi.org/10.1016/j.xphs.2017.03.022
Autor:
Erin Rubin, Wei Yue, Kar Ming Fung, Jonathan Miller, Kai Ding, Feng Yin, Sonia Pahwa, Alexandra Crowe, Khondoker Alam, Wei Zheng
Publikováno v:
Pharm Res
PURPOSE: Membrane transport protein organic anion transporting polypeptide (OATP) 1B1 mediates hepatic uptake of many drugs (e.g. statins). The OATP1B1 c.521T>C (p. V174A) polymorphism has reduced transport activity. Conflicting in vitro results exis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc0f05bcdea4b9bbb15c46b458afe68
https://doi.org/10.1007/s11095-019-2634-3
https://doi.org/10.1007/s11095-019-2634-3
Autor:
Pengyue Zhang, Sonia Pahwa, Alaa H. Abuznait, Wei Yue, Lang Li, Kai Ding, Xueying Wang, Khondoker Alam
Publikováno v:
Molecular Pharmaceutics. 13:839-851
Organic anion transporting polypeptide (OATP) 1B1 mediates the hepatic uptake of many drugs including lipid-lowering statins. Decreased OATP1B1 transport activity is often associated with increased systemic exposure of statins and statin-induced myop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69762246d47be832cc04ab2e19fee47d
https://doi.org/10.1021/acs.molpharmaceut.5b00763
https://doi.org/10.1021/acs.molpharmaceut.5b00763
Publikováno v:
ACS Combinatorial Science
Primary hits that arise from screening one bead one compound (OBOC) libraries against a target of interest rarely have high potency. However, there has been little work focused on the development of an efficient workflow for primary hit improvement.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc757714bd8680d213916bf744cdfc4
https://doi.org/10.1021/co500154e
https://doi.org/10.1021/co500154e