The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells

Autor: Sonia Núñez-Vázquez, José Saura-Esteller, Ismael Sánchez-Vera, Emma Guilbaud, Ana M. Cosialls, Gabriel Pons, Jean-Ehrland Ricci, Daniel Iglesias-Serret, Sandrine Marchetti, Joan Gil

Publikováno v: Oncogenesis, Vol 10, Iss 9, Pp 1-9 (2021)

Abstract Fluorizoline is a prohibitin-binding compound that triggers apoptosis in several cell lines from murine and human origin, as well as in primary cells from hematologic malignancies by inducing the integrated stress response and ER stress. Rec

Externí odkaz: https://doaj.org/article/f799a128a61940b9862994fb4054ab1e

The Prohibitin-Binding Compound Fluorizoline Activates the Integrated Stress Response through the eIF2α Kinase HRI

Autor: Ismael Sánchez-Vera, Sonia Núñez-Vázquez, José Saura-Esteller, Ana M. Cosialls, Judith Heib, Pau Nadal Rodríguez, Ouldouz Ghashghaei, Rodolfo Lavilla, Gabriel Pons, Joan Gil, Daniel Iglesias-Serret

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8064

Fluorizoline is a synthetic molecule that induces apoptosis, by selectively targeting prohibitins (PHBs), through induction of the BH3-only protein NOXA. This induction is transcriptionally regulated by the integrated stress response (ISR)-related tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611fd67a46e5fd25be7d665c119e97a1

Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines

Autor: Pablo M. Garcia-Roves, Gauri Bhosale, Lorena Mendive-Tapia, Ismael Sánchez-Vera, Sonia Núñez-Vázquez, Michael R. Duchen, Pau Gama-Perez, Gabriel Pons, Rodolfo Lavilla, Daniel Iglesias-Serret, Ana M. Cosialls, Joan Gil, José Saura-Esteller

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 6117, p 6117 (2021)

The prohibitin (PHB)-binding compound fluorizoline as well as PHB-downregulation activate the integrated stress response (ISR) in HEK293T and U2OS human cell lines. This activation is denoted by phosphorylation of eIF2α and increases in ATF4, ATF3,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf55405285e675df6a64d29f68cee6b5
http://hdl.handle.net/2445/178630

Fluorizoline-induced apoptosis requires prohibitins in nematodes and human cells

Autor: José, Saura-Esteller, Ismael, Sánchez-Vera, Sonia, Núñez-Vázquez, Judith, Jabalquinto-Carrasco, Ana M, Cosialls, Lorena, Mendive-Tapia, Dmytro, Kukhtar, Manuel D, Martínez-Bueno, Rodolfo, Lavilla, Julián, Cerón, Marta, Artal-Sanz, Gabriel, Pons, Daniel, Iglesias-Serret, Joan, Gil

Publikováno v: Apoptosis : an international journal on programmed cell death. 26(1-2)

We previously showed that fluorizoline, a fluorinated thiazoline compound, binds to both subunits of the mitochondrial prohibitin (PHB) complex, PHB1 and PHB2, being the expression of these proteins required for fluorizoline-induced apoptosis in mous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afcb1501ef5d66833c8f7afa43a9425e
https://pubmed.ncbi.nlm.nih.gov/33387147

NOXA upregulation by the prohibitin-binding compound fluorizoline is transcriptionally regulated by integrated stress response-induced ATF3 and ATF4

Autor: Joan Gil, Gabriel Pons, Ana M. Cosialls, Ismael Sánchez-Vera, Sonia Núñez-Vázquez, José Saura-Esteller, Rodolfo Lavilla, Daniel Iglesias-Serret, Fernando Albericio, Anaïs F.M. Noisier

Publikováno v: The FEBS journalReferences. 288(4)

Fluorizoline is a new synthetic molecule that induces p53-independent apoptosis, in several tumor cell lines and in primary leukemia cells, by selectively targeting prohibitins (PHBs). In this study, we describe how fluorizoline induces BCL-2 homolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c488cdf3fbc8871023e9b7988f27aaea
https://pubmed.ncbi.nlm.nih.gov/32648994