Sampling the Conformational Energy Landscape of a Hyperthermophilic Protein by Engineering Key Substitutions

Autor: Martin J. Field, Alexey Aleksandrov, Nicolas Coquelle, Dominique Madern, Elena Mendoza-Barberá, Sonia Mraihi, Jacques-Philippe Colletier

Publikováno v: Molecular Biology and Evolution
Molecular Biology and Evolution, Oxford University Press (OUP), 2012, 29 (6), pp.1683-94. ⟨10.1093/molbev/mss015⟩
Molecular Biology and Evolution, 2012, 29 (6), pp.1683-94. ⟨10.1093/molbev/mss015⟩

International audience; Proteins exist as a dynamic ensemble of interconverting substates, which defines their conformational energy landscapes. Recent work has indicated that mutations that shift the balance between conformational substates (CSs) ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cad6f4acec81c3293db17169f4ea99a
https://doi.org/10.1093/molbev/mss015