Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by Legionella

Autor: Sonia Mondino, Silke Schmidt, Carmen Buchrieser

Publikováno v: mBio, Vol 11, Iss 5 (2020)

ABSTRACT Through coevolution with host cells, microorganisms have acquired mechanisms to avoid the detection by the host surveillance system and to use the cell’s supplies to establish themselves. Indeed, certain pathogens have evolved proteins tha

Externí odkaz: https://doaj.org/article/6d1b5ad0e1714d00a1c8fbe23676a0da

A conditional mutant of the fatty acid synthase unveils unexpected cross talks in mycobacterial lipid metabolism

Autor: Matías Cabruja, Sonia Mondino, Yi Ting Tsai, Julia Lara, Hugo Gramajo, Gabriela Gago

Publikováno v: Open Biology, Vol 7, Iss 2 (2017)

Unlike most bacteria, mycobacteria rely on the multi-domain enzyme eukaryote-like fatty acid synthase I (FAS I) to make fatty acids de novo. These metabolites are precursors of the biosynthesis of most of the lipids present both in the complex mycoba

Externí odkaz: https://doaj.org/article/179fc9dd6ee248edb55aa994aaeec310

Molecular Mimicry: a Paradigm of Host-Microbe Coevolution Illustrated by Legionella

Autor: Silke Schmidt, Carmen Buchrieser, Sonia Mondino

Publikováno v: mBio
mBio, American Society for Microbiology, 2020, 11 (5), pp.e01201-20. ⟨10.1128/mBio.01201-20⟩
mBio, Vol 11, Iss 5 (2020)
mBio, 2020, 11 (5), pp.e01201-20. ⟨10.1128/mBio.01201-20⟩

Through coevolution with host cells, microorganisms have acquired mechanisms to avoid the detection by the host surveillance system and to use the cell’s supplies to establish themselves. Indeed, certain pathogens have evolved proteins that imitate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadda993b22632095d4d5cad3ebbf42b
https://doi.org/10.1128/mbio.01201-20

Legionnaires’ Disease: State of the Art Knowledge of Pathogenesis Mechanisms of Legionella

Autor: Carmen Buchrieser, Sonia Mondino, Silke Schmidt, Laura Gomez-Valero, Monica Rolando, Pedro Escoll

Publikováno v: Annual Review of Pathology: Mechanisms of Disease
Annual Review of Pathology: Mechanisms of Disease, Annual Reviews, 2020, 15 (1), pp.439-466. ⟨10.1146/annurev-pathmechdis-012419-032742⟩
Annual Review of Pathology: Mechanisms of Disease, 2020, 15 (1), pp.439-466. ⟨10.1146/annurev-pathmechdis-012419-032742⟩

International audience; Legionella species are environmental gram-negative bacteria able to cause a severe form of pneumonia in humans known as Legionnaires' disease. Since the identification of Legionella pneumophila in 1977, four decades of researc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37cbad9a1db873f79779f3afb741c36
https://hal-pasteur.archives-ouvertes.fr/pasteur-02565930/document

More than 18,000 effectors in the

Autor: Laura, Gomez-Valero, Christophe, Rusniok, Danielle, Carson, Sonia, Mondino, Ana Elena, Pérez-Cobas, Monica, Rolando, Shivani, Pasricha, Sandra, Reuter, Jasmin, Demirtas, Johannes, Crumbach, Stephane, Descorps-Declere, Elizabeth L, Hartland, Sophie, Jarraud, Gordon, Dougan, Gunnar N, Schroeder, Gad, Frankel, Carmen, Buchrieser

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 116(6)

The genus Legionella comprises 65 species, among which Legionella pneumophila is a human pathogen causing severe pneumonia. To understand the evolution of an environmental to an accidental human pathogen, we have functionally analyzed 80 Legionella g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b6f2bd730df964e4c60a36e280bb751
https://pubmed.ncbi.nlm.nih.gov/30659146