Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sonia M. Scaria"'
Autor:
Sonia M. Scaria, Stacey M. Frumm, Ellee P. Vikram, Sarah A. Easow, Amar H. Sheth, Eliah R. Shamir, Shengyang Kevin Yu, Aaron D. Tward
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract Adult mammals are generally believed to have limited ability to regenerate complex tissues and instead, repair wounds by forming scars. In humans and across mammalian species, the tympanic membrane (TM) rapidly repairs perforations without i
Externí odkaz:
https://doaj.org/article/7aeb28bf6fef41d69353f88e6b5b2a56
Autor:
Lynne Chantranupong, Rachel L. Wolfson, Jose M. Orozco, Robert A. Saxton, Sonia M. Scaria, Liron Bar-Peled, Eric Spooner, Marta Isasa, Steven P. Gygi, David M. Sabatini
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 1-8 (2014)
Summary: The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell growth that responds to numerous environmental cues. A key input is amino acids, which act through the heterodimeric Rag GTPases (RagA or RagB bound t
Externí odkaz:
https://doaj.org/article/c9bca710a90f4b2a84f1d20f8fd2edb3
Autor:
Sonia M. Scaria, Aaron D. Tward
Publikováno v:
Otologyneurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 43(8)
Inflammatory external auditory canal (EAC) Stenosis arises from infiltration of inflammatory cells, edema and eventual sclerosing of the medial EAC, leading to complete obstruction and conductive hearing loss. Current treatment includes surgical rese
Autor:
Julie B. Sneddon, Stacey M. Frumm, Shengyang Kevin Yu, Katharine Lee, Sonia M. Scaria, Lauren Byrnes, Joseph Chang, Aaron D. Tward, Jordan Artichoker
Publikováno v:
Cell stem cell, vol 28, iss 2
Cell Stem Cell
Cell Stem Cell
The tympanic membrane (TM) is critical for hearing and requires continuous clearing of cellular debris, but little is known about homeostatic mechanisms in the TM epidermis. Using single-cell RNA sequencing, lineage tracing, whole-organ explant, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672048c4b4cd9746822d7d4296a98566
https://escholarship.org/uc/item/22b599rv
https://escholarship.org/uc/item/22b599rv
Autor:
Jonathan S. Weissman, Thomas M. Norman, Jeffrey A. Hussmann, Daniel Assis Santos, Marco Jost, Carol A. Gross, Max A. Horlbeck, Christina R. Liem, Sonia M. Scaria, John S. Hawkins, Reuben A. Saunders
Publikováno v:
Nature biotechnology, vol 38, iss 3
Nature biotechnology
Nature biotechnology
A lack of tools to precisely control gene expression has limited our ability to evaluate relationships between expression levels and phenotypes. Here, we describe an approach to titrate expression of human genes using CRISPR interference and series o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a18424dceee00a556f6e21f73690f5
https://escholarship.org/uc/item/14s573qj
https://escholarship.org/uc/item/14s573qj
Autor:
Andrew L. Cangelosi, Sonia M. Scaria, Jose M. Orozco, Caroline A. Lewis, Tenzin Kunchok, Sze Ham Chan, David M. Sabatini, Patrycja A. Krawczyk
Publikováno v:
Nature metabolism
In response to nutrients, the mTOR complex 1 (mTORC1) kinase regulates cell growth by setting the balance between anabolic and catabolic processes. To be active, mTORC1 requires the environmental presence of amino acids and glucose, which provide the
Autor:
Jonathan S. Weissman, John S. Hawkins, Christina R. Liem, Marco Jost, Sonia M. Scaria, Max A. Horlbeck, Reuben A. Saunders, Thomas M. Norman, Daniel Assis Santos, Jeffrey A. Hussmann, Carol A. Gross
Biological phenotypes arise from the degrees to which genes are expressed, but the lack of tools to precisely control gene expression limits our ability to evaluate the underlying expression-phenotype relationships. Here, we describe a readily implem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fd8a5913c7c7fe903b65b3206b68c2
Autor:
David M. Sabatini, Sonia M. Scaria, Kuang Shen, Rachel L. Wolfson, Robert A. Saxton, Lynne Chantranupong, Jason R. Cantor
Publikováno v:
Science. 351:43-48
From sensing leucine to metabolic control The mTORC1 protein kinase complex plays central roles in regulating cell growth and metabolism and is implicated in common human diseases such as diabetes and cancer. The level of the amino acid leucine tells
Autor:
Steven P. Gygi, Jose M. Orozco, J. Wade Harper, David M. Sabatini, Xin Gu, Kendall J. Condon, Robert A. Saxton, Patrycja A. Krawczyk, Sonia M. Scaria, Grace Y. Liu
Publikováno v:
PMC
mTOR complex 1 (mTORC1) regulates cell growth and metabolism in response to multiple environmental cues. Nutrients signal via the Rag guanosine triphosphatases (GTPases) to promote the localization of mTORC1 to the lysosomal surface, its site of acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33fcc4c55a228fdd977974001579634
http://hdl.handle.net/1721.1/120131
http://hdl.handle.net/1721.1/120131
Autor:
J. Wade Harper, David M. Sabatini, Gregory A. Wyant, Kuang Shen, Timothy C. Wang, Lynne Chantranupong, Robert A. Saxton, Melanie P. Gygi, Steven P. Gygi, Sonia M. Scaria
Publikováno v:
PMC
Amino acids signal to the mTOR complex I (mTORC1) growth pathway through the Rag GTPases. Multiple distinct complexes regulate the Rags, including GATOR1, a GTPase activating protein (GAP), and GATOR2, a positive regulator of unknown molecular functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5848f332254ba1834fc620fe2e6fb052
https://orcid.org/0000-0002-1446-7256
https://orcid.org/0000-0002-1446-7256