Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Sonia M, Parnell"'
Autor:
Emilie J. Cosway, Kieran D. James, Andrea J. White, Sonia M. Parnell, Andrea Bacon, Andrew N. J. McKenzie, W. E. Jenkinson, Graham Anderson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract As the primary site of T-cell development, the thymus dictates immune competency of the host. The rates of thymus function are not constant, and thymus regeneration is essential to restore new T-cell production following tissue damage from e
Externí odkaz:
https://doaj.org/article/2f6fc6882f6e4f17b1ea21f1939791f2
Autor:
Beth Lucas, Andrea J. White, Fabian Klein, Clara Veiga-Villauriz, Adam Handel, Andrea Bacon, Emilie J. Cosway, Kieran D. James, Sonia M. Parnell, Izumi Ohigashi, Yousuke Takahama, William E. Jenkinson, Georg A. Hollander, Wei-Yu Lu, Graham Anderson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The thymus medulla is a key site for immunoregulation and tolerance, and its functional specialisation is achieved through the complexity of medullary thymic epithelial cells (mTEC). While the importance of the medulla for thymus function is
Externí odkaz:
https://doaj.org/article/2a0c9868ae7e45eaa4dd7a3a89e0aac1
Autor:
Beth Lucas, Andrea J. White, Emilie J. Cosway, Sonia M. Parnell, Kieran D. James, Nick D. Jones, Izumi Ohigashi, Yousuke Takahama, William E. Jenkinson, Graham Anderson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation
Externí odkaz:
https://doaj.org/article/a71a0ce69050482687895e76227ecd62
Autor:
Beth Lucas, Andrea J. White, Sonia M. Parnell, Peter M. Henley, William E. Jenkinson, Graham Anderson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The ordered migration of immature thymocytes through thymic microenvironments generates both adaptive MHC restricted αβT-cells and innate CD1d-restricted iNKT-cells. While several chemokine receptors and ligands control multiple stages of
Externí odkaz:
https://doaj.org/article/b9b26475765442e6a982e5ae43e28e35
Autor:
Emilie J. Cosway, Andrea J. White, Sonia M. Parnell, Edina Schweighoffer, Helen E. Jolin, Andrea Bacon, Hans-Reimer Rodewald, Victor Tybulewicz, Andrew N. J. McKenzie, William E. Jenkinson, Graham Anderson
Publikováno v:
Science immunology. 7(69)
Therapeutic interventions used for cancer treatment provoke thymus damage and limit the recovery of protective immunity. Here, we show that eosinophils are an essential part of an intrathymic type 2 immune network that enables thymus recovery after a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8297804b6b50ac594eda43d133d9ec0
https://pubmed.ncbi.nlm.nih.gov/35275754
https://pubmed.ncbi.nlm.nih.gov/35275754
Autor:
Abdullah S. Alawam, Emilie J. Cosway, Kieran D. James, Beth Lucas, Andrea Bacon, Sonia M. Parnell, Andrea J. White, William E. Jenkinson, Graham Anderson
Publikováno v:
The Journal of Experimental Medicine
The thymus ensures immune tolerance by synchronizing thymocyte development and selection. Alawam et al. show that a functional uncoupling of these events occurs after bone marrow transplantation, which results in post-transplant tolerance loss and au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc063c0a2ede900ee3115d6ad0dbfa7
http://europepmc.org/articles/PMC8679781
http://europepmc.org/articles/PMC8679781
Autor:
Graham Anderson, Vladimir Purvanov, Sonia M. Parnell, Andrea J. White, William E. Jenkinson, Yousuke Takahama, Kieran D. James, Daniel F. Legler, Izumi Ohigashi
Publikováno v:
Blood Adv
The release of newly selected αβT cells from the thymus is key in establishing a functional adaptive immune system. Emigration of the first cohorts of αβT cells produced during the neonatal period is of particular importance, because it initiates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ef8ff18ea4f71e083d40be053aeb55
https://europepmc.org/articles/PMC7805325/
https://europepmc.org/articles/PMC7805325/
Autor:
Kyoko Nakamura, Andrea J White, Sonia M Parnell, Peter J Lane, Eric J Jenkinson, William E Jenkinson, Graham Anderson
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74019 (2013)
Thymocytes expressing the invariant Vγ5 γδT-cell receptor represent progenitors of dendritic epidermal T-cells (DETC) that play an important immune surveillance role in the skin. In contrast to the bulk of αβT-cell development, Vγ5(+) DETC prog
Externí odkaz:
https://doaj.org/article/19d7ad03e71e47e8aed8222ac1830aaa
Autor:
Graham Anderson, Izumi Ohigashi, William E. Jenkinson, Andrea J. White, Beth Lucas, Kieran D. James, Nick D. Jones, Emilie J. Cosway, Sonia M. Parnell, Yousuke Takahama
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The thymus supports multiple αβ T cell lineages that are functionally distinct, but mechanisms that control this multifaceted development are poorly understood. Here we examine medullary thymic epithelial cell (mTEC) heterogeneity and its influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912937b69d56381c25d80769a51bad22
https://doi.org/10.1038/s41467-020-16041-x
https://doi.org/10.1038/s41467-020-16041-x
Autor:
Susan M. Kaech, Nicholas I. McCarthy, Natalie A. Roberts, Sonia M. Parnell, Reuben Tooze, Graham Anderson, Brian D. Adams, Valerie Horsley
Publikováno v:
The Journal of Immunology Author Choice
Autoimmunity is largely prevented by medullary thymic epithelial cells (TECs) through their expression and presentation of tissue-specific Ags to developing thymocytes, resulting in deletion of self-reactive T cells and supporting regulatory T cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634f1d2bca22540351cfc143fadfabcd
https://doi.org/10.4049/jimmunol.1600941
https://doi.org/10.4049/jimmunol.1600941