Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sonia Leonardelli"'
Autor:
Frank A. Giordano, Julian P. Layer, Sonia Leonardelli, Lea L. Friker, Roberta Turiello, Dillon Corvino, Thomas Zeyen, Christina Schaub, Wolf Müller, Elena Sperk, Leonard Christopher Schmeel, Katharina Sahm, Christoph Oster, Sied Kebir, Peter Hambsch, Torsten Pietsch, Sotirios Bisdas, Michael Platten, Martin Glas, Clemens Seidel, Ulrich Herrlinger, Michael Hölzel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The chemokine CXCL12 promotes glioblastoma (GBM) recurrence after radiotherapy (RT) by facilitating vasculogenesis. Here we report outcomes of the dose-escalation part of GLORIA (NCT04121455), a phase I/II trial combining RT and the CXCL12-n
Externí odkaz:
https://doaj.org/article/a461b70c215e421cabb2b9a14f5dfb4b
Autor:
Caterina Giraulo, Roberta Turiello, Lavinia Orlando, Sonia Leonardelli, Jennifer Landsberg, Raffaella Belvedere, Georg Rolshoven, Christa E. Müller, Michael Hölzel, Silvana Morello
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115225- (2023)
CD73 is the key enzyme in the generation of extracellular adenosine, a mediator involved in tumor progression, tumor immune escape and resistance to anti-cancer therapeutics. Microenvironmental conditions influence the expression of CD73 in tumor cel
Externí odkaz:
https://doaj.org/article/2d01d7fab2754c648cad5647ebf10af7
Autor:
Benjamin Krämer, Ansel P. Nalin, Feiyang Ma, Sarah Eickhoff, Philipp Lutz, Sonia Leonardelli, Felix Goeser, Claudia Finnemann, Gudrun Hack, Jan Raabe, Michael ToVinh, Sarah Ahmad, Christoph Hoffmeister, Kim M. Kaiser, Steffen Manekeller, Vittorio Branchi, Tobias Bald, Michael Hölzel, Robert Hüneburg, Hans Dieter Nischalke, Alexander Semaan, Bettina Langhans, Dominik J. Kaczmarek, Brooke Benner, Matthew R. Lordo, Jesse Kowalski, Adam Gerhardt, Jörg Timm, Marieta Toma, Raphael Mohr, Andreas Türler, Arthur Charpentier, Tobias van Bremen, Georg Feldmann, Arne Sattler, Katja Kotsch, Ali T. Abdallah, Christian P. Strassburg, Ulrich Spengler, William E. Carson, III, Bethany L. Mundy-Bosse, Matteo Pellegrini, Timothy E. O’Sullivan, Aharon G. Freud, Jacob Nattermann
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111937- (2023)
Summary: Group 1 innate lymphoid cells (ILCs) comprise a heterogeneous family of cytotoxic natural killer (NK) cells and ILC1s. We identify a population of “liver-type” ILC1s with transcriptional, phenotypic, and functional features distinct from
Externí odkaz:
https://doaj.org/article/0084e5451ed64fc0b420c8bfd7ffa888
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/7c4fe57afa274abeb247aa5b0c7ffd92
Autor:
Laura K. Esser, Vittorio Branchi, Sonia Leonardelli, Natalie Pelusi, Adrian G. Simon, Niklas Klümper, Jörg Ellinger, Stefan Hauser, Maria A. Gonzalez-Carmona, Manuel Ritter, Glen Kristiansen, Hubert Schorle, Michael Hölzel, Marieta I. Toma
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer accounting for 80% of all renal cancers as well as the majority of renal cancer-associated deaths. During the last decade, the treatment paradigm for ccRCC has radically changed.
Externí odkaz:
https://doaj.org/article/97d1d568f6ac4813aad29aec50665885
Autor:
Natalia Pieper, Anne Zaremba, Sonia Leonardelli, Franziska Noelle Harbers, Marion Schwamborn, Silke Lübcke, Barbara Schrörs, Jolanthe Baingo, Alexander Schramm, Sebastian Haferkamp, Ulrike Seifert, Antje Sucker, Volker Lennerz, Thomas Wölfel, Dirk Schadendorf, Bastian Schilling, Annette Paschen, Fang Zhao
Publikováno v:
OncoImmunology, Vol 7, Iss 8 (2018)
The profound but frequently transient clinical responses to BRAFV600 inhibitor (BRAFi) treatment in melanoma emphasize the need for combinatorial therapies. Multiple clinical trials combining BRAFi and immunotherapy are under way to further enhance t
Externí odkaz:
https://doaj.org/article/ba763546e68d4a68931ae0d1bfff33bf
Autor:
Luiza Martins Nascentes Melo, Dayana Herrera-Rios, Daniel Hinze, Stefanie Löffek, Irem Oezel, Roberta Turiello, Juliane Klein, Sonia Leonardelli, Isa-Vanessa Westedt, Yahya Al-Matary, Sara Egea-Rodriguez, Alexandra Brenzel, Maja Bau, Antje Sucker, Eva Hadaschik, Florian Wirsdörfer, Helmut Hanenberg, Niklas Uhlenbrock, Daniel Rauh, Joanna Poźniak, Florian Rambow, Jean-Christophe Marine, Maike Effern, Nicole Glodde, Dirk Schadendorf, Jadwiga Jablonska, Michael Hölzel, Iris Helfrich
BackgroundImmune responses against tumors are subject to negative feedback regulation. Immune checkpoint inhibitors (ICIs) blocking Programmed cell death protein 1 (PD-1), a receptor expressed on T cells, or its ligand PD-L1 have significantly improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e635e007e7980f60883552af314d2074
https://www.ncbi.nlm.nih.gov/pubmed/37028818
https://www.ncbi.nlm.nih.gov/pubmed/37028818
Autor:
Frank Anton Giordano, Julian Philipp Layer, Sonia Leonardelli, Lea Lydia Friker, Clemens Seidel, Christina Schaub, Roberta Turiello, Elena Sperk, Franziska Grau, Daniel Paech, Barbara Link, Wolf Mueller, Ghazaleh Tabatabai, Katharina Sahm, Sied Kebir, Torsten Pietsch, Martin Glas, Sotiros Bisdas, Ulrich Herrlinger, Michael Hölzel
2050 Background: Pre-clinical studies consistently demonstrate that inhibition of the CXCL12/CXCR4/CXCR7 axis abrogates recruitment of pro-vasculogenic bone marrow-derived cells after radiotherapy (RT) of glioblastoma (GBM) and promotes T cell exclus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c3acd320b7be115008633c54cafa12
Autor:
Frank Giordano, Julian Layer, Sonia Leonardelli, Lea Friker, Christina Schaub, Roberta Turiello, Elena Sperk, Iris Mildenberger, Franziska Grau, Daniel Paech, Torsten Pietsch, Wolf Mueller, Oliver Grauer, Mirjam Renovanz, Ghazaleh Tabatabai, Sied Kebir, Martin Glas, Sotirios Bisdas, Peter Hambsch, Clemens Seidel, Michael Hölzel, Ulrich Herrlinger
Publikováno v:
Neuro-Oncology. 24:vii88-vii88
BACKGROUND We recently reported favorable safety, promising clinical efficacy and immunohistochemical indicators of response after radiotherapy (RT) plus escalating doses of the CXCL12-neutralizing RNA-Spiegelmer olaptesed pegol (NOX-A12) for gliobla
Autor:
Clemens Seidel, Katharina Sahm, Thomas Zeyen, Sotirios Bisdas, Frank A. Giordano, Elena Sperk, Sied Kebir, Julian P Layer, Ulrich Herrlinger, Sonia Leonardelli, Martin Glas, Lea Friker, Torsten Pietsch, Christina Schaub, Peter Hambsch, Michael Hölzel
Publikováno v:
Neuro Oncol
BACKGROUND Preclinical studies showed that CXCL12-mediated influx of highly angiogenic monocytes/macrophages is a key driver of tumor re-vascularization and re-growth after radiotherapy (RT) of glioblastoma (GBM). We report findings from a phase I/II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e295cf828fb360634306c6dddeec1c