Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sonia L Evagelou"'
Targeted genome editing in vivo corrects a Dmd duplication restoring wild‐type dystrophin expression
Autor:
Eleonora Maino, Daria Wojtal, Sonia L Evagelou, Aiman Farheen, Tatianna W Y Wong, Kyle Lindsay, Ori Scott, Samar Z Rizvi, Elzbieta Hyatt, Matthew Rok, Shagana Visuvanathan, Amanda Chiodo, Michelle Schneeweiss, Evgueni A Ivakine, Ronald D Cohn
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 5, Pp n/a-n/a (2021)
Abstract Tandem duplication mutations are increasingly found to be the direct cause of many rare heritable diseases, accounting for up to 10% of cases. Unfortunately, animal models recapitulating such mutations are scarce, limiting our ability to stu
Externí odkaz:
https://doaj.org/article/79b8670d90524c9f9b3d247d4ec1653b
Autor:
Allen C.T. Teng, Marjan Tavassoli, Suja Shrestha, Ryan M. Marks, Meghan J. McFadden, Sonia L. Evagelou, Kyle Lindsay, Ava Vandenbelt, Wenping Li, Evgueni Ivakine, Ronald Cohn, J. Paul Santerre, Anthony O. Gramolini
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101933- (2023)
Summary: Here, we describe a protocol for purifying functional clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9) from Staphylococcus aureus within 24 h and over 90% purity. SaCas9 purification begins with
Externí odkaz:
https://doaj.org/article/d1573157b4e54e4c84f54302f66cee69
Autor:
Antonio Mollica, Safia Omer, Sonia L. Evagelou, Serhiy Naumenko, Lu Yi Li, Aideen Teeling, Kyle Lindsay, Steven Erwood, Robert M. Vernon, Julie D. Forman-Kay, Manohar Shroff, Rene E. Harrison, Ronald D. Cohn, Evgueni A. Ivakine
Tubulinopathies and neurodevelopmental ciliopathies are two groups of genetic disorders characterized by abnormal brain development resulting in structural brain malformations. Tubulinopathies are caused by dominant missense mutations in genes encodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66302f73209109abe5ce17590e19efe2
https://doi.org/10.1101/2023.05.23.23290232
https://doi.org/10.1101/2023.05.23.23290232
Autor:
J.J. David Ho, Miling Wang, Timothy E. Audas, Deukwoo Kwon, Steven K. Carlsson, Sara Timpano, Sonia L. Evagelou, Shaun Brothers, Mark L. Gonzalgo, Jonathan R. Krieger, Steven Chen, James Uniacke, Stephen Lee
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1293-1300 (2016)
Protein concentrations evolve under greater evolutionary constraint than mRNA levels. Translation efficiency of mRNA represents the chief determinant of basal protein concentrations. This raises a fundamental question of how mRNA and protein levels a
Externí odkaz:
https://doaj.org/article/bedf0004e3654887b81b21831af96206
Publikováno v:
Mol Cell Biol
Hypoxia is a deficiency in oxygen delivery to tissues and is connected to physiological and pathophysiological processes such as embryonic development and cancer. The master regulators of oxygen homeostasis in mammalian cells are the heterodimeric hy
Hypoxia occurs when there is a deficiency in oxygen delivery to tissues and is connected to physiological and pathophysiological processes such as embryonic development, wound healing, heart disease and cancer. The master regulators of oxygen homeost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ebd402fa468909a79fd21374330157
https://doi.org/10.1101/632331
https://doi.org/10.1101/632331
Autor:
Timothy E. Audas, Sara Timpano, Steven K. Carlsson, J.J. David Ho, Steven Xi Chen, Mark L. Gonzalgo, Stephen Lee, Jonathan R. Krieger, Sonia L. Evagelou, Deukwoo Kwon, James Uniacke, Miling Wang
Publikováno v:
Cell Reports, Vol 14, Iss 6, Pp 1293-1300 (2016)
SummaryProtein concentrations evolve under greater evolutionary constraint than mRNA levels. Translation efficiency of mRNA represents the chief determinant of basal protein concentrations. This raises a fundamental question of how mRNA and protein l
Autor:
Erin J. Specker, James Uniacke, Brianna D. Guild, Sara Timpano, Gaelan Melanson, Sonia L. Evagelou
Publikováno v:
Journal of Visualized Experiments.
Translational control is a focal point of gene regulation, especially during periods of cellular stress. Cap-dependent translation via the eIF4F complex is by far the most common pathway to initiate protein synthesis in eukaryotic cells, but stress-s