Toward Single-Peak Dalbavancin Analogs through Biology and Chemistry

Autor: Sonia I. Maffioli, Stefano Donadio, Cristina Brunati, Silke Alt, Alice Bernasconi, Margherita Sosio

Publikováno v: ACS Chemical Biology. 14:356-360

Glycopeptide antibiotics are used to treat severe multidrug resistant infections caused by Gram-positive bacteria. Dalbavancin is a second generation glycopeptide approved for human use, which is obtained from A40926, a lipoglycopeptide produced by N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9345f605d188331f8a680bb88a5df5
https://doi.org/10.1021/acschembio.9b00050

Effective approaches to discover new microbial metabolites in a large strain library

Autor: Guadalupe S. Zarazúa, Marianna Iorio, Arianna Tocchetti, Mitja M Zdouc, Margherita Sosio, Cristina Brunati, Matteo Simone, Stefania Serina, Kristiina Vind, Max Crüsemann, Paolo Monciardini, Stefano Donadio, Sonia I. Maffioli

Publikováno v: Journal of Industrial Microbiology and Biotechnology
Journal of Industrial Microbiology and Biotechnology, 48(3-4)
Journal of Industrial Microbiology and Biotechnology 48 (2021) 3-4

Natural products have provided many molecules to treat and prevent illnesses in humans, animals and plants. While only a small fraction of the existing microbial diversity has been explored for bioactive metabolites, tens of thousands of molecules ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e41e7f3c4b8d748c36a078b7fa82197
https://doi.org/10.1093/jimb/kuab017

Metabolomic investigation of the pseudouridimycin producer, a prolific streptomycete

Autor: Stefania Serina, Sonia I. Maffioli, Davatgarbenam S, Matteo Simone, Marianna Iorio, Mitja M Zdouc, Richard H. Ebright, Margherita Sosio, Stefano Donadio, Criscenzo P

Publikováno v: BioRxiv
bioRxiv

We report a metabolomic analysis of Streptomyces sp. ID38640, a soil isolate that produces the bacterial RNA polymerase inhibitor pseudouridimycin. The analysis was performed on the wild type and on ten different pum mutants blocked at different step

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22741053bec7faf9864d6e5c74c82865
https://doi.org/10.1101/2020.11.05.369249

Antibacterial Paramagnetic Quinones from Actinoallomurus

Autor: Sonia I. Maffioli, Alice Bernasconi, Marianna Iorio, João C. S. Cruz, Margherita Sosio, Matteo Simone, Stefano Donadio, Cristina Brunati

Publikováno v: Journal of Natural Products. 80:819-827

Four metabolites, designated paramagnetoquinone A, B, C, and D (1-4), were isolated from three strains belonging to the actinomycete genus Actinoallomurus. Compounds 1 and 2 showed potent antibacterial activity with MIC values lower than 0.015 μg/mL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345380ce0019443cc78186257bd04f81
https://doi.org/10.1021/acs.jnatprod.6b00654

Iron chelation increases the tolerance of Escherichia coli to hyper-replication stress

Autor: Charlotte Dahlmann Liboriussen, Peter W. Thulstrup, Rasmus N. Klitgaard, Godefroid Charbon, Sonia I. Maffioli, Stefano Donadio, Anders Løbner-Olesen

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Charbon, G, Klitgaard, R N, Liboriussen, C D, Thulstrup, P W, Maffioli, S I, Donadio, S & Løbner-Olesen, A 2018, ' Iron chelation increases the tolerance of Escherichia coli to hyper-replication stress ', Scientific Reports, vol. 8, no. 1, 10550 . https://doi.org/10.1038/s41598-018-28841-9

In Escherichia coli, an increase in the frequency of chromosome replication is lethal. In order to identify compounds that affect chromosome replication, we screened for molecules capable of restoring the viability of hyper-replicating cells. We made

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3a12634caa9bd94218b6a99e6ca7cd
https://doi.org/10.1038/s41598-018-28841-9