A circular RNA generated from an intron of the insulin gene controls insulin secretion

Autor: Lisa Stoll, Adriana Rodríguez-Trejo, Claudiane Guay, Flora Brozzi, Mustafa Bilal Bayazit, Sonia Gattesco, Véronique Menoud, Jonathan Sobel, Ana Claudia Marques, Morten Trillingsgaard Venø, Jonathan Lou S. Esguerra, Mohammad Barghouth, Mara Suleiman, Lorella Marselli, Jørgen Kjems, Lena Eliasson, Erik Renström, Karim Bouzakri, Michel Pinget, Piero Marchetti, Romano Regazzi

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Circular RNAs contribute to the regulation of β-cell specific functions. Here the authors show that a circular RNA derived from one of the introns of the insulin gene is necessary for optimal insulin secretion from pancreatic islets and that its lev

Externí odkaz: https://doaj.org/article/114bb60757e446fba74489bec09b7aca

Identification of islet-enriched long non-coding RNAs contributing to β-cell failure in type 2 diabetes

Autor: Romano Regazzi, Ana Gómez-Ruiz, Frédéric Burdet, Marc Prentki, Patrick Gilon, Mark Ibberson, Sonia Gattesco, Jonathan L.S. Esguerra, Lena Eliasson, D. Ross Laybutt, Anna Motterle, Marie-Line Peyot

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 6, Iss 11, Pp 1407-1418 (2017)
Molecular metabolism, vol. 6, no. 11, pp. 1407-1418
Molecular Metabolism, Vol. 6, p. 1407-1418 (2017)

Objective Non-coding RNAs constitute a major fraction of the β-cell transcriptome. While the involvement of microRNAs is well established, the contribution of long non-coding RNAs (lncRNAs) in the regulation of β-cell functions and in diabetes deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f85c654d861e6a27463a702e4355ef8
https://doi.org/10.1016/j.molmet.2017.08.005

Involvement of long non-coding RNAs in beta cell failure at the onset of type 1 diabetes in NOD mice

Autor: Sonia Gattesco, Paolo Meda, Dorothée Caille, Anna Motterle, Romano Regazzi

Publikováno v: DIABETOLOGIA
Diabetologia, vol. 58, no. 8, pp. 1827-1835

AIMS/HYPOTHESIS: Exposure of pancreatic beta cells to cytokines released by islet-infiltrating immune cells induces alterations in gene expression, leading to impaired insulin secretion and apoptosis in the initial phases of type 1 diabetes. Long non

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3378666bbf56a8bd1622cb6d41b34e
http://serval.unil.ch/?id=serval:BIB_45CC7D2FCA43

Changes in MicroRNA Expression Contribute to Pancreatic β-Cell Dysfunction in Prediabetic NOD Mice

Autor: Dorothée Caille, Romano Regazzi, E. Roggli, Sonia Gattesco, Christian Boitard, Paolo Meda, Claire Briet

Publikováno v: Diabetes, vol. 61, no. 7, pp. 1742-1751
Diabetes

During the initial phases of type 1 diabetes, pancreatic islets are invaded by immune cells, exposing β-cells to proinflammatory cytokines. This unfavorable environment results in gene expression modifications leading to loss of β-cell functions. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d4c5e3ab7c6e1f9ec5e1c622a4a701
https://doi.org/10.2337/db11-1086

Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction

Autor: Christian Widmann, Amar Abderrahmani, Sonia Gattesco, Pascal Lovis, E. Roggli, Jiang-Yan Yang, D. Ross Laybutt, Romano Regazzi

Publikováno v: Diabetes
Diabetes, vol. 57, no. 10, pp. 2728-2736

OBJECTIVE—Visceral obesity and elevated plasma free fatty acids are predisposing factors for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic β-cells, resulting in reduced insulin content, defective insulin secretion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0c344daa753799191a151f0965d83f
http://europepmc.org/articles/PMC2551683