Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sonia G. Rao"'
Autor:
Nathan A. Ungerleider, Sonia G. Rao, Ashkan Shahbandi, Douglas Yee, Tianhua Niu, Wesley D. Frey, James G. Jackson
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-8 (2018)
Abstract Background Previous studies on the role of TP53 mutation in breast cancer treatment response and survival are contradictory and inconclusive, limited by the use of different endpoints to determine clinical significance and by small sample si
Externí odkaz:
https://doaj.org/article/1fb9b45ae40b4b3084592a92d28e0690
Autor:
Crystal Tonnessen-Murray, Nathan A. Ungerleider, Sonia G. Rao, Amanda R. Wasylishen, Wesley D. Frey, James G. Jackson
Publikováno v:
Translational Oncology, Vol 11, Iss 4, Pp 930-940 (2018)
p53 is a transcription factor that regulates expression of genes involved in cell cycle arrest, senescence, and apoptosis. TP53 harbors mutations that inactivate its transcriptional activity in roughly 30% of breast cancers, and these tumors are much
Externí odkaz:
https://doaj.org/article/219224837bbe40a1ba8df7a8ee501849
Autor:
Ashkan Shahbandi, Fang-Yen Chiu, Nathan A. Ungerleider, Raegan Kvadas, Zeinab Mheidly, Meijuan J. S. Sun, Di Tian, Daniel A. Waizman, Ashlyn Y. Anderson, Heather L. Machado, Zachary F. Pursell, Sonia G. Rao, James G. Jackson
Publikováno v:
Nat Cancer
Breast cancer cells must avoid intrinsic and extrinsic cell death to relapse following chemotherapy. Entering senescence enables survival from mitotic catastrophe, apoptosis and nutrient deprivation, but mechanisms of immune evasion are poorly unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35bdae22d7d0d891154e2e8cd42df2f
https://pubmed.ncbi.nlm.nih.gov/36482233
https://pubmed.ncbi.nlm.nih.gov/36482233
Autor:
Sonia G. Rao, Crystal A. Tonnessen-Murray, Benjamin T. Vinson, Ashkan Shahbandi, Joy O. Olayiwola, Nathan Ungerleider, James G. Jackson, Douglas B. Chrisey, Christopher J. Lord, Lucas B. Murray, Wesley D. Frey
Publikováno v:
Journal of Cell Biology. 218:3827-3844
In chemotherapy-treated breast cancer, wild-type p53 preferentially induces senescence over apoptosis, resulting in a persisting cell population constituting residual disease that drives relapse and poor patient survival via the senescence-associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec78dd7cafa4d4886d28c30ec784cac
https://doi.org/10.1083/jcb.201904051
https://doi.org/10.1083/jcb.201904051
Autor:
Ashkan Shahbandi, Fang-Yen Chiu, Nathan A. Ungerleider, Ashlyn Y. Anderson, Heather L. Machado, Zachary F. Pursell, Raegan Kvadas, Sonia G. Rao, James G. Jackson
Publikováno v:
Cancer Research. 82:1297-1297
We and others have previously shown that the breast cancers most difficult to eradicate with chemotherapy are TP53 wild-type, and these are among the most lethal breast cancers. For instance, chemotherapy-treated TNBC patients with TP53 wild-type tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09b1f418b72ee834d54bfe96b4802759
https://doi.org/10.1158/1538-7445.am2022-1297
https://doi.org/10.1158/1538-7445.am2022-1297
Autor:
Nathan Ungerleider, Ashlyn Y. Anderson, Ashkan Shahbandi, Joy O. Olayiwola, Sonia G. Rao, Wesley D. Frey, James G. Jackson
Publikováno v:
Cell Death Differ
TP53 wild-type breast tumors rarely undergo a complete pathological response after chemotherapy treatment. These patients have an extremely poor survival rate and studies show these tumors preferentially undergo senescence instead of apoptosis. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a899b0db2827a93b47ac63dd469081
https://pubmed.ncbi.nlm.nih.gov/32457483
https://pubmed.ncbi.nlm.nih.gov/32457483
Autor:
Nathan Ungerleider, Amanda R. Wasylishen, James G. Jackson, Crystal A. Tonnessen-Murray, Sonia G. Rao, Wesley D. Frey
Publikováno v:
Translational Oncology, Vol 11, Iss 4, Pp 930-940 (2018)
Translational Oncology
Translational Oncology
p53 is a transcription factor that regulates expression of genes involved in cell cycle arrest, senescence, and apoptosis. TP53 harbors mutations that inactivate its transcriptional activity in roughly 30% of breast cancers, and these tumors are much
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb629a651bdc557028ef266b4e63582
http://www.sciencedirect.com/science/article/pii/S1936523318301761
http://www.sciencedirect.com/science/article/pii/S1936523318301761
Autor:
James G. Jackson, Ashkan Shahbandi, Nathan Ungerleider, Sonia G. Rao, Wesley D. Frey, Tianhua Niu, Douglas Yee
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-8 (2018)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Background Previous studies on the role of TP53 mutation in breast cancer treatment response and survival are contradictory and inconclusive, limited by the use of different endpoints to determine clinical significance and by small sample sizes that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb2ee0e619a98f2a86466e153075f4b
https://doi.org/10.1186/s13058-018-1044-5
https://doi.org/10.1186/s13058-018-1044-5
Autor:
Sonia G. Rao, James G. Jackson
Publikováno v:
Trends in cancer. 2(11)
Cellular senescence is a permanent growth arrest in cells with damage or stress that could lead to transformation. Some tumor cells also undergo senescence in response to chemotherapy. Senescent cells secrete cytokines and other factors of the senesc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69797fced663de405db3d9dd01643fcf
https://pubmed.ncbi.nlm.nih.gov/28741506
https://pubmed.ncbi.nlm.nih.gov/28741506