Beneficial effects of the phytocannabinoid Δ9-THCV in L-DOPA-induced dyskinesia in Parkinson's disease

Autor: Isabel Espadas, Ettel Keifman, Cristina Palomo-Garo, Sonia Burgaz, Concepción García, Javier Fernández-Ruiz, Rosario Moratalla

Publikováno v: Neurobiology of Disease, Vol 141, Iss , Pp 104892- (2020)

The antioxidant and CB2 receptor agonist properties of Δ9-tetrahydrocannabivarin (Δ9-THCV) afforded neuroprotection in experimental Parkinson's disease (PD), whereas its CB1 receptor antagonist profile at doses lower than 5 mg/kg caused anti-hypoki

Externí odkaz: https://doaj.org/article/75d2c8fb4bf945dcaacdb0a8d5fceac6

Preclinical Investigation in Neuroprotective Effects of the GPR55 Ligand VCE-006.1 in Experimental Models of Parkinson’s Disease and Amyotrophic Lateral Sclerosis

Autor: Sonia Burgaz, Concepción García, Claudia Gonzalo-Consuegra, Marta Gómez-Almería, Francisco Ruiz-Pino, Juan Diego Unciti, María Gómez-Cañas, Juan Alcalde, Paula Morales, Nadine Jagerovic, Carmen Rodríguez-Cueto, Eva de Lago, Eduardo Muñoz, Javier Fernández-Ruiz

Publikováno v: Molecules, Vol 26, Iss 24, p 7643 (2021)

Cannabinoids act as pleiotropic compounds exerting, among others, a broad-spectrum of neuroprotective effects. These effects have been investigated in the last years in different preclinical models of neurodegeneration, with the cannabinoid type-1 (C

Externí odkaz: https://doaj.org/article/4a88a818e83d475a8337cdef7ec47035

Neuroprotection with the Cannabidiol Quinone Derivative VCE-004.8 (EHP-101) against 6-Hydroxydopamine in Cell and Murine Models of Parkinson’s Disease

Autor: Sonia Burgaz, Concepción García, María Gómez-Cañas, Alain Rolland, Eduardo Muñoz, Javier Fernández-Ruiz

Publikováno v: Molecules, Vol 26, Iss 11, p 3245 (2021)

The 3-hydroxyquinone derivative of the non-psychotrophic phytocannabinoid cannabigerol, so-called VCE-003.2, and some other derivatives have been recently investigated for neuroprotective properties in experimental models of Parkinson’s disease (PD

Externí odkaz: https://doaj.org/article/55142c8699664604a79734d5d10264a8

BiP Heterozigosity Aggravates Pathological Deterioration in Experimental Amyotrophic Lateral Sclerosis

Autor: Eva de Lago, Carlos Costas-Insua, Concepción García, Javier Fernández-Ruiz, Irene Santos-García, Marta Gómez-Almería, Carmen Rodríguez-Cueto, Ignacio Rodríguez-Crespo, Sonia Burgaz, Manuel Guzmán

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 12533, p 12533 (2021)
E-Prints Complutense. Archivo Institucional de la UCM
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Volume 22
Issue 22

In the present study, we investigated the involvement of the chaperone protein BiP (also known as GRP78 or Hspa5), a master regulator of intracellular proteostasis, in two mouse models of neurodegenerative diseases: amyotrophic lateral sclerosis (ALS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4bc1bfd855af5e80951c7965f9221ce
https://eprints.ucm.es/id/eprint/71672/

Neuroprotection with the cannabigerol quinone derivative VCE-003.2 and its analogs CBGA-Q and CBGA-Q-Salt in Parkinson's disease using 6-hydroxydopamine-lesioned mice

Autor: Eva Muñoz, Carmen del Río, Concepción García, María José Casarejos, Eduardo Muñoz, Alain Rolland, María Gómez-Cañas, Claudia Gonzalo-Consuegra, Javier Fernández-Ruiz, Carmen Navarrete, Sonia Burgaz, Adela García-Martín

Publikováno v: Molecular and cellular neurosciences. 110

The quinone derivative of the non-psychotropic cannabinoid cannabigerol (CBG), so-called VCE-003.2, has been recently investigated for its neuroprotective properties in inflammatory models of Parkinson's disease (PD) in mice. Such potential derives f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7b2e6b7214a7a4f9cc3f60fba8911e
https://pubmed.ncbi.nlm.nih.gov/33338634