Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sonia Brockway"'
Autor:
Sonia Brockway, Geng Wang, Jasen M. Jackson, David R. Amici, Seesha R. Takagishi, Matthew R. Clutter, Elizabeth T. Bartom, Marc L. Mendillo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Identifying chemical-genetic interactions in mammalian cells is limited to low-throughput or computational methods. Here, the authors present QMAP-Seq, a broadly accessible and scalable approach that uses NGS for pooled high-throughput chemical-genet
Externí odkaz:
https://doaj.org/article/0bffba70303d49d6bfb6d4bae9916ae3
CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response
Autor:
Abdul S. Qadir, Paolo Ceppi, Sonia Brockway, Calvin Law, Liang Mu, Nikolai N. Khodarev, Jung Kim, Jonathan C. Zhao, William Putzbach, Andrea E. Murmann, Zhuo Chen, Wenjing Chen, Xia Liu, Arthur R. Salomon, Huiping Liu, Ralph R. Weichselbaum, Jindan Yu, Marcus E. Peter
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2373-2386 (2017)
Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that this involves activation of signal transducer and activator of transcription 1 (STAT1) and induction of STAT1-regulated genes and that this process is inhibited
Externí odkaz:
https://doaj.org/article/d9d2c0eccc6c4397b26f9a483be369d9
Autor:
Abbas Hadji, Paolo Ceppi, Andrea E. Murmann, Sonia Brockway, Abhinandan Pattanayak, Bhavneet Bhinder, Annika Hau, Shirley De Chant, Vamsi Parimi, Piotre Kolesza, JoAnne Richards, Navdeep Chandel, Hakim Djaballah, Marcus E. Peter
Publikováno v:
Cell Reports, Vol 7, Iss 1, Pp 208-222 (2014)
CD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. We now show that elimination of CD95 or CD95L results in a form of cell death that is independent of caspase-8, RIPK1/MLKL, and p53, is not inhibited by Bcl-
Externí odkaz:
https://doaj.org/article/259dd43c9ca746b4af0d5d9ec8e14da5
Autor:
David R. Amici, Daniel J. Ansel, Kyle A. Metz, Roger S. Smith, Claire M. Phoumyvong, Sitaram Gayatri, Tomasz Chamera, Stacey L. Edwards, Brendan P. O’Hara, Shashank Srivastava, Sonia Brockway, Seesha R. Takagishi, Byoung-Kyu Cho, Young Ah Goo, Neil L. Kelleher, Issam Ben-Sahra, Daniel R. Foltz, Jian Li, Marc L. Mendillo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(27)
All cells contain specialized signaling pathways that enable adaptation to specific molecular stressors. Yet, whether these pathways are centrally regulated in complex physiological stress states remains unclear. Using genome-scale fitness screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612574b745d235dad5ad16c6dfed76f2
https://pubmed.ncbi.nlm.nih.gov/35776542
https://pubmed.ncbi.nlm.nih.gov/35776542
Autor:
Roger S. Smith, Seesha R. Takagishi, David R. Amici, Kyle Metz, Sitaram Gayatri, Milad J. Alasady, Yaqi Wu, Sonia Brockway, Stephanie L. Taiberg, Natalia Khalatyan, Mikko Taipale, Sandro Santagata, Luke Whitesell, Susan Lindquist, Jeffrey N. Savas, Marc L. Mendillo
Publikováno v:
Science advances. 8(11)
Heat shock factor 1 (HSF1) is well known for its role in the heat shock response (HSR), where it drives a transcriptional program comprising heat shock protein (HSP) genes, and in tumorigenesis, where it drives a program comprising HSPs and many nonc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd0c319734e37c4d394bc1c690a661a
https://pubmed.ncbi.nlm.nih.gov/35294249
https://pubmed.ncbi.nlm.nih.gov/35294249
Autor:
Elizabeth T. Bartom, Sonia Brockway, Seesha R. Takagishi, Jasen M. Jackson, Geng Wang, Matthew R. Clutter, Marc L. Mendillo, David R. Amici
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Chemical-genetic interaction profiling in model organisms has proven powerful in providing insights into compound mechanism of action and gene function. However, identifying chemical-genetic interactions in mammalian systems has been limited to low-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ababc0fc52d669a24456f1c9ad131cfd
https://pubmed.ncbi.nlm.nih.gov/33184288
https://pubmed.ncbi.nlm.nih.gov/33184288
CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response
Autor:
Liang Mu, Abdul S. Qadir, Sonia Brockway, Jonathan C. Zhao, Jung Kim, Calvin Law, Marcus E. Peter, Arthur R. Salomon, Wenjing Chen, Andrea E. Murmann, Ralph R. Weichselbaum, Zhuo Chen, Nikolai N. Khodarev, Jindan Yu, Paolo Ceppi, William Putzbach, Xia Liu, Huiping Liu
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2373-2386 (2017)
Stimulation of CD95/Fas drives and maintains cancer stem cells (CSCs). We now report that this involves activation of signal transducer and activator of transcription 1 (STAT1) and induction of STAT1-regulated genes and that this process is inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd520c5eee98ed0907fc5c9a3086f94
Autor:
Byoung Kyu Cho, David R. Amici, Daniel R. Foltz, Daniel J. Ansel, Kyle A. Metz, Neil L. Kelleher, Sonia Brockway, Jasen M. Jackson, Roger S. Smith, Marc L. Mendillo, Young Ah Goo, Seesha R. Takagishi, Brendan P. O’Hara, Issam Ben-Sahra, Shashank Srivastava
SummaryThe interrelated programs essential for cellular fitness in the face of stress are critical to understanding tumorigenesis, neurodegeneration, and aging. However, modelling the combinatorial landscape of stresses experienced by diseased cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef20e290fedf9d3013f25c9c5780f8fc
Autor:
Abhinandan Pattanayak, Sonia Brockway, Abbas Hadji, Paolo Ceppi, Andrea E. Murmann, Marcus E. Peter, William Putzbach
Publikováno v:
Cell Death and Differentiation
CD95 (Fas/APO-1) and its ligand, CD95L, have long been viewed as a death receptor/death ligand system that mediates apoptosis induction to maintain immune homeostasis. In addition, these molecules are important in the immune elimination of virus-infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5602d85edea426bc84ff3328d4df47f0
http://europepmc.org/articles/PMC4356349
http://europepmc.org/articles/PMC4356349
Autor:
C. Shad Thaxton, Ashley Haluck-Kangas, Andrea E. Murmann, Marcus E. Peter, Kaylin M. McMahon, Jian-Jun Wei, Sonia Brockway, Monal Patel, Calvin Law, Nandini Ravindran
// Andrea E. Murmann 1 , Kaylin M. McMahon 3,6 , Ashley Haluck-Kangas 1 , Nandini Ravindran 1 , Monal Patel 1 , Calvin Y. Law 1 , Sonia Brockway 1 , Jian-Jun Wei 4 , C. Shad Thaxton 3,5,6,7 and Marcus E. Peter 1,2,5 1 Department of Medicine/Division
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80d2010606f57f3bf36e2d0c1239bc0