Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sonia Bernetiere"'
Autor:
Dennis Bigg, Simon P. Newman, Chloe Stengel, Sonia Bernetiere, Raphael Dellile, Mark Carlson, José Camara, Eric Ferrandis, Mélissa Le Moing, Nadine Narboux, Vincent Hesry, Delphine Morlais, Olivier Dutruel, Dominique Pons, Pierrick Auvray, Anne-Marie Liberatore, Philip G. Kasprzyk, Hélène Coulomb, Ann Savola Nelson, Béatrice Foll, Gregoire Prevost
Publikováno v:
Molecular Cancer Therapeutics. 7:2426-2434
Tubulin is a validated target for antitumor drugs. However, the effectiveness of these microtubule-interacting agents is limited by the fact that they are substrates for drug efflux pumps (P-glycoprotein) and/or by the acquisition of point mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1e8e70f3246309738f21d393b63bf5b
https://doi.org/10.1158/1535-7163.mct-08-0208
https://doi.org/10.1158/1535-7163.mct-08-0208
Autor:
Valerie Brault, Sonia Bernetiere, José Camara, Pascale Plas, Pierre Roubert, Lydie Poitout, Carole Sackur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4464-4470
A novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood-brain barrier after intravenous do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd422ef705bb9e0089e5f9af72d36fe1
https://doi.org/10.1016/j.bmcl.2007.06.010
https://doi.org/10.1016/j.bmcl.2007.06.010
Autor:
Paul A, Foster, Simon P, Newman, Mathew P, Leese, Sonia, Bernetiere, Christian, Diolez, Jose, Camara, Beatrice, Hacher, Marie-Madeleine, Baronnet, Tauhid, Ali, Barry V L, Potter, Michael J, Reed, Atul, Purohit
Publikováno v:
Anticancer research. 28(2A)
There is a continued need for orally bioavailable anticancer compounds that exhibit good efficacy against breast cancer. STX140, a derivative of 2-methoxyestradiol (2-MeOE2), has been shown to have excellent oral bioavailability and significantly red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16a527c5ea8889ab8890fa7acc4d1266
https://pubmed.ncbi.nlm.nih.gov/18506995
https://pubmed.ncbi.nlm.nih.gov/18506995
Autor:
Florence Meyer-Losic, Simon P. Newman, Pierre Roubert, Atul Purohit, Mark Carlson, M P Leese, Paul A. Foster, Ann Fiore, Charleen Oligo, Laurent Vignaux, Jeffrey Lauer, Hervé Gaudry, Philip G. Kasprzyk, Sonia Bernetiere
Publikováno v:
Cancer Research. 72:2795-2795
STX-140 is an anti-tubulin binding agent which has demonstrated a good anti-tumor efficacy profile. Although the binding site on tubulin differs from other classical tubulin binders, one could anticipate the same type of safety issues with such an ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55204869d44b4978533a5267e2d550c9
https://doi.org/10.1158/1538-7445.am2012-2795
https://doi.org/10.1158/1538-7445.am2012-2795