Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sonia B. Sidhu"'
Autor:
Hannele Ruohola-Baker, R. David Hawkins, Damien Detraux, Julie Mathieu, Cheng Dong, Woojin Kim, Chao Xu, Aaron M. Robitaille, Luke T. Dang, Lauren Carter, James D. Moody, Shiri Levy, Jinrong Min, Yuliang Wang, Amy Ferreccio, Stuart H. Orkin, David Baker, Randall T. Moon, Cristina Valensisi, Licheng Zhu, Wolfram Tempel, Sonia B. Sidhu, Yalan Xing
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(38)
The polycomb repressive complex 2 (PRC2) histone methyltransferase plays a central role in epigenetic regulation in development and in cancer, and hence to interrogate its role in a specific developmental transition, methods are needed for disrupting
Autor:
Julie Mathieu, Logeshwaran Somasundaram, Hannele Ruohola-Baker, Sonia B. Sidhu, Aaron M. Robitaille, A. McAlister, T. Bottorff, Damien Detraux, Randall T. Moon, Filippo Artoni, R. D. Hawkins, Daniel A. Kuppers, Patrick J. Paddison, Amy Ferreccio, Carol B. Ware, Christopher Cavanaugh, Shiri Levy, Yuliang Wang, Stephanie L. Battle
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Mathieu, J, Detraux, D, Kuppers, D, Wang, Y, Cavanaugh, C, Sidhu, S, Levy, S, Robitaille, A M, Ferreccio, A, Bottorff, T, McAlister, A, Somasundaram, L, Artoni, F, Battle, S, Hawkins, R D, Moon, R T, Ware, C B, Paddison, P J & Ruohola-Baker, H 2019, ' Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency ', Nature Communications, vol. 10, no. 1, 632, pp. 632 . https://doi.org/10.1038/s41467-018-08020-0
Nature Communications
Mathieu, J, Detraux, D, Kuppers, D, Wang, Y, Cavanaugh, C, Sidhu, S, Levy, S, Robitaille, A M, Ferreccio, A, Bottorff, T, McAlister, A, Somasundaram, L, Artoni, F, Battle, S, Hawkins, R D, Moon, R T, Ware, C B, Paddison, P J & Ruohola-Baker, H 2019, ' Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency ', Nature Communications, vol. 10, no. 1, 632, pp. 632 . https://doi.org/10.1038/s41467-018-08020-0
Nature Communications
To reveal how cells exit human pluripotency, we designed a CRISPR-Cas9 screen exploiting the metabolic and epigenetic differences between naïve and primed pluripotent cells. We identify the tumor suppressor, Folliculin(FLCN) as a critical gene requi
Autor:
Abdiasis M. Hussein, Amy Ferreccio, Damien Detraux, Christopher Cavanaugh, Filippo Artoni, Patrick J. Paddison, Thomas Bello, Bryce L. Sopher, Carol B. Ware, Nathan J. Palpant, Charles E. Murry, Hans Reinecke, Hannele Ruohola-Baker, Suman Jayadev, Julie Mathieu, Logeshwaran Somasundaram, Savannah Cook, Karin A. Fischer, Sonia B. Sidhu, Shiri Levy, Yuliang Wang
Publikováno v:
Cell Cycle. :00-00
To easily edit the genome of naïve human embryonic stem cells (hESC), we introduced a dual cassette encoding an inducible Cas9 into the AAVS1 site of naïve hESC (iCas9). The iCas9 line retained karyotypic stability, expression of pluripotency marke