The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science

Autor: Jena V. Lilly, Jo Lynne Rokita, Jennifer L. Mason, Tatiana Patton, Stephanie Stefankiewiz, David Higgins, Gerri Trooskin, Carina A. Larouci, Kamnaa Arya, Elizabeth Appert, Allison P. Heath, Yuankun Zhu, Miguel A. Brown, Bo Zhang, Bailey K. Farrow, Shannon Robins, Allison M. Morgan, Thinh Q. Nguyen, Elizabeth Frenkel, Kaitlin Lehmann, Emily Drake, Catherine Sullivan, Alexa Plisiewicz, Noel Coleman, Luke Patterson, Mateusz Koptyra, Zeinab Helili, Nicholas Van Kuren, Nathan Young, Meen Chul Kim, Christopher Friedman, Alex Lubneuski, Christopher Blackden, Marti Williams, Valerie Baubet, Lamiya Tauhid, Jamie Galanaugh, Katie Boucher, Heba Ijaz, Kristina A. Cole, Namrata Choudhari, Mariarita Santi, Robert W. Moulder, Jonathan Waller, Whitney Rife, Sharon J. Diskin, Marion Mateos, Donald W. Parsons, Ian F. Pollack, Stewart Goldman, Sarah Leary, Chiara Caporalini, Anna Maria Buccoliero, Mirko Scagnet, David Haussler, Derek Hanson, Ron Firestein, Jason Cain, Joanna J. Phillips, Nalin Gupta, Sabine Mueller, Gerald Grant, Michelle Monje-Deisseroth, Sonia Partap, Jeffrey P. Greenfield, Rintaro Hashizume, Amy Smith, Shida Zhu, James M. Johnston, Jason R. Fangusaro, Matthew Miller, Matthew D. Wood, Sharon Gardner, Claire L. Carter, Laura M. Prolo, Jared Pisapia, Katherine Pehlivan, Andrea Franson, Toba Niazi, Josh Rubin, Mohamed Abdelbaki, David S. Ziegler, Holly B. Lindsay, Ana Guerreiro Stucklin, Nicolas Gerber, Olena M. Vaske, Carolyn Quinsey, Brian R. Rood, Javad Nazarian, Eric Raabe, Eric M. Jackson, Stacie Stapleton, Robert M. Lober, David E. Kram, Carl Koschmann, Phillip B. Storm, Rishi R. Lulla, Michael Prados, Adam C. Resnick, Angela J. Waanders

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 35, Iss , Pp 100846- (2023)

Pediatric brain tumors are the leading cause of cancer-related death in children in the United States and contribute a disproportionate number of potential years of life lost compared to adult cancers. Moreover, survivors frequently suffer long-term

Externí odkaz: https://doaj.org/article/ccba034296a747dd98510c07ca0814c3

Tumor inflammation-associated neurotoxicity

Autor: Jasia Mahdi, Jorg Dietrich, Karin Straathof, Claire Roddie, Brian J. Scott, Tom Belle Davidson, Laura M. Prolo, Tracy T. Batchelor, Cynthia J. Campen, Kara L. Davis, Juliane Gust, Michael Lim, Robbie G. Majzner, Julie R. Park, Sonia Partap, Sneha Ramakrishna, Rebecca Richards, Liora Schultz, Nicholas A. Vitanza, Leo D. Wang, Crystal L. Mackall, Michelle Monje

Publikováno v: Nature Medicine. 29:803-810

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::143fe1066eb3e5fc3eb3433c75c86c2f
https://doi.org/10.1038/s41591-023-02276-w

Molecular classification and outcome of children with rare CNS embryonal tumors: results from St. Jude Children’s Research Hospital including the multi-center SJYC07 and SJMB03 clinical trials

Autor: Anthony P. Y. Liu, Sandeep K. Dhanda, Tong Lin, Edgar Sioson, Aksana Vasilyeva, Brian Gudenas, Ruth G. Tatevossian, Sujuan Jia, Geoffrey Neale, Daniel C. Bowers, Tim Hassall, Sonia Partap, John R. Crawford, Murali Chintagumpala, Eric Bouffet, Geoff McCowage, Alberto Broniscer, Ibrahim Qaddoumi, Greg Armstrong, Karen D. Wright, Santhosh A. Upadhyaya, Anna Vinitsky, Christopher L. Tinkle, John Lucas, Jason Chiang, Daniel J. Indelicato, Robert Sanders, Paul Klimo, Frederick A. Boop, Thomas E. Merchant, David W. Ellison, Paul A. Northcott, Brent A. Orr, Xin Zhou, Arzu Onar-Thomas, Amar Gajjar, Giles W. Robinson

Publikováno v: Acta Neuropathologica. 144:733-746

Methylation profiling has radically transformed our understanding of tumors previously called central nervous system primitive neuro-ectodermal tumors (CNS-PNET). While this marks a momentous step toward defining key differences, reclassification has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de637cda9026768842fa1f9a26a7ce19
https://doi.org/10.1007/s00401-022-02484-7

Data from Relevance of Molecular Groups in Children with Newly Diagnosed Atypical Teratoid Rhabdoid Tumor: Results from Prospective St. Jude Multi-institutional Trials

Autor: Amar Gajjar, David W. Ellison, Marcel Kool, Thomas E. Merchant, Frederick A. Boop, Kim E. Nichols, Daniel J. Indelicato, Zoltan Patay, Paul Klimo, Robert P. Sanders, Roya Mostafavi, Sridharan Gururangan, Eric Bouffet, Murali Chintagumpala, John R. Crawford, Paul G. Fisher, Sonia Partap, Tim Hassall, Anne E. Bendel, Gregory T. Armstrong, Anna Vinitsky, Ibrahim Qaddoumi, Alberto Broniscer, Ashok Srinivasan, Sandeep Kumar Dhanda, Ruth G. Tatevossian, Catherine A. Billups, Gang Wu, Pascal Johann, Brent A. Orr, Arzu Onar-Thomas, Giles W. Robinson, Santhosh A. Upadhyaya

Purpose:Report relevance of molecular groups to clinicopathologic features, germline SMARCB1/SMARCA4 alterations (GLA), and survival of children with atypical teratoid rhabdoid tumor (ATRT) treated in two multi-institutional clinical trials.Materials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b29fb4f16e48c14f46b5194fc53bbec
https://doi.org/10.1158/1078-0432.c.6530039

Phase II study of everolimus for recurrent or progressive pediatric ependymoma

Autor: Daniel C Bowers, Veena Rajaram, Matthias A Karajannis, Sharon L Gardner, Jack Meng-Fen Su, Patricia Baxter, Sonia Partap, Laura J Klesse

Publikováno v: Neuro-Oncology Advances. 5

BackgroundPreclinical studies have suggested that mTOR pathway signaling may be a potential therapeutic target for childhood ependymoma.MethodsA phase II clinical trial (ClinicalTrials.gov identifier: NCT02155920) of single-agent everolimus was perfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c40f2f61450243900a3676f914e80993
https://doi.org/10.1093/noajnl/vdad011