Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Sonia, Espinosa"'
Autor:
Montse Erra, Jordi Gràcia, Joan Taltavull, Lluís Pagès, Elena Calama, María Domínguez, J.F. Caturla, Sonia Espinosa, F.J. Bernal, M. Carrascal, Mónica Bravo, M. I. Maldonado, Begoña Hernández, M Sabate, Montserrat Miralpeix, Marta Calbet, Stephane Paris, Lehner, M. Mir
Publikováno v:
Journal of Medicinal Chemistry. 61:9551-9567
Oral PI3Kδ inhibitors such as Idelalisib and Duvelisib have shown efficacy as anticancer agents and Idelalisib has been approved for the treatment of three B-cell cancers. However, Idelalisib has a black box warning on its product label regarding th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8eb77a673cefaa1d74c30859d39900e
https://doi.org/10.1021/acs.jmedchem.8b00873
https://doi.org/10.1021/acs.jmedchem.8b00873
Autor:
Josep M. Huerta, Montserrat Miralpeix, Sonia Espinosa, Dolors Vilella, Carlos Puig, Israel Ramos, Amadeu Gavaldà, Mònica Aparici, Maria Letosa
Publikováno v:
European Journal of Pharmacology. 819:89-97
This study describes the association rate and residence time of abediterol, a novel long-acting β2-adrenoceptor agonist (LABA) in Phase II development for treatment of asthma and COPD, in comparison with indacaterol, olodaterol, vilanterol and salme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a48c87c835e4e873e031a05acca8f8d6
https://doi.org/10.1016/j.ejphar.2017.11.043
https://doi.org/10.1016/j.ejphar.2017.11.043
Autor:
Luisa Coderch, Cristina Alonso, Victor Carrer, Bernat Vidal, Mònica Córdoba, Mercè Pont, María Domínguez, Nuria Godessart, Sonia Espinosa, Miriam Zanuy
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
The main challenge of topically applied drugs is to overcome the skin barrier to reach the site of action at the concentration needed for efficacy. In the research of new topical drugs, design of molecules with optimized properties for skin penetrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9c583056d981a24a362068d1053c56
https://pubmed.ncbi.nlm.nih.gov/31163216
https://pubmed.ncbi.nlm.nih.gov/31163216
Autor:
Luisa Coderch, Mònica Córdoba, Cristina Alonso, Clara Barba, Mercè Pont, Meritxell Martí, Victor Carrer, Miriam Zanuy, Sonia Espinosa, Marc A. Oliver
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Propylene glycol (PG) has been used in formulations as a co-solvent and/or to enhance drug permeation through the skin from topical preparations. Two skin in vitro permeation approaches are used to determine the effect of PG on drug penetration. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156fcf63d988323836df327c1d4261a0
http://hdl.handle.net/10261/210437
http://hdl.handle.net/10261/210437
Autor:
Elisabeth Bosch, Axel Andrés, Sonia Espinosa, Victor Segarra, Josep M. Huerta, Clara Ràfols, Martí Rosés
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Several procedures based on the shake-flask method and designed to require a minimum amount of drug for octanol-water partition coefficient determination have been established and developed. The procedures have been validated by a 28 substance set wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c796e662de7085999a350ed689533a
https://doi.org/10.1016/j.ejps.2015.05.008
https://doi.org/10.1016/j.ejps.2015.05.008
Autor:
Maria Antonia Buil, Manuel Fuentes Ferrer, Sonia Espinosa, Francisca Antón, Jordi Castro, Josep M. Huerta, Jorge Beleta, Manuel López, Mònica Córdoba, Dolors Vilella, Montserrat Miralpeix, Gaspar Casals, Maria Prat, Victor Segarra, Maria Dolors Fernández, Hamish Ryder, Marisa González, Alvaro Cardenas, Juan Manuel Monleón, Israel Ramos, Laia Tort, Amadeu Gavaldà
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1736-1741
Novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides have been identified as potent M3 muscarinic antagonists with a long duration of action in an in vivo model of bronchoconstriction. The synthesis, structure-activity relationships and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430af71f81dd784dd8e3710b416eebc5
https://doi.org/10.1016/j.bmcl.2015.02.065
https://doi.org/10.1016/j.bmcl.2015.02.065
Autor:
Israel, Ramos, Mònica, Aparici, Maria, Letosa, Carlos, Puig, Amadeu, Gavaldà, Josep Maria, Huerta, Sonia, Espinosa, Dolors, Vilella, Montserrat, Miralpeix
Publikováno v:
European journal of pharmacology. 819
This study describes the association rate and residence time of abediterol, a novel long-acting β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c95406c2759b1e4046ef7abb226e66b
https://pubmed.ncbi.nlm.nih.gov/29183838
https://pubmed.ncbi.nlm.nih.gov/29183838
Publikováno v:
Journal of Molecular Cell Biology
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Europe PubMed Central
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
Europe PubMed Central
Tissue factor (TF) signaling regulates gene expression and protein synthesis leading to the modulation of cell function. Recently, we have demonstrated in microvascular endothelial cells (mECs) that TF signaling induces activation of ETS1 transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3009b6dc520a971a7cb6c5bd1c2025da
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7278
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=7278
Autor:
Joan Albertí, Manuel Fuentes Ferrer, Sonia Sentellas, María I. Crespo, Hamish Ryder, Amadeu Gavaldà, Jorge Beleta, Israel Ramos, M. Antonia Buil, Sonia Espinosa, Manuel López, Jordi Castro, Maria Prat, Francisca Antón, Josep M. Huerta, Dolors Fernández, Marisa González, Gaspar Casals, Dolors Vilella, Teresa Doménech, Victor Segarra, Montserrat Miralpeix, Alvaro Cardenas, Juan Manuel Monleón, Laia Tort
Publikováno v:
Journal of Medicinal Chemistry. 52:5076-5092
The objective of this work was to discover a novel, long-acting muscarinic M3 antagonist for the inhaled treatment of chronic obstructive pulmonary disease (COPD), with a potentially improved risk−benefit profile compared with current antimuscarini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45428bc44e0992b58d50d3c5f07d6aa2
https://doi.org/10.1021/jm900132z
https://doi.org/10.1021/jm900132z
Publikováno v:
Analytica Chimica Acta. 454:157-166
The acid–base constants of several bases (aniline, pyridine, ammonia, ethanolamine, and triethylamine) in acetonitrile–water mixtures up to 60% of acetonitrile by volume have been potentiometrically determined. Two different pH scales have been u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57afe7f5d01d1edf0b7b29b126b11bcd
https://doi.org/10.1016/s0003-2670(01)01541-0
https://doi.org/10.1016/s0003-2670(01)01541-0