Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Soni S. Pullamsetti"'
Autor:
Matthias S. Leisegang, Jasleen Kaur Bains, Sandra Seredinski, James A. Oo, Nina M. Krause, Chao-Chung Kuo, Stefan Günther, Nevcin Sentürk Cetin, Timothy Warwick, Can Cao, Frederike Boos, Judit Izquierdo Ponce, Shaza Haydar, Rebecca Bednarz, Chanil Valasarajan, Dominik C. Fuhrmann, Jens Preussner, Mario Looso, Soni S. Pullamsetti, Marcel H. Schulz, Hendrik R. A. Jonker, Christian Richter, Flávia Rezende, Ralf Gilsbach, Beatrice Pflüger-Müller, Ilka Wittig, Ingrid Grummt, Teodora Ribarska, Ivan G. Costa, Harald Schwalbe, Ralf P. Brandes
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Using a composite bioinformatics approach, the DNA:DNA:RNA triplex-forming lncRNAs HIF1α-AS1 was identified in human endothelial cells which recruits an epigenetic silencing complex to limit expression of triplex target genes.
Externí odkaz:
https://doaj.org/article/c3f7ecd225714cd98fa4bafc76a4baa2
Autor:
Jaco Selle, Katharina Dinger, Vanessa Jentgen, Daniela Zanetti, Johannes Will, Theodoros Georgomanolis, Christina Vohlen, Rebecca Wilke, Baktybek Kojonazarov, Oleksiy Klymenko, Jasmine Mohr, Silke v. Koningsbruggen-Rietschel, Christopher J. Rhodes, Anna Ulrich, Dharmesh Hirani, Tim Nestler, Margarete Odenthal, Esther Mahabir, Sreenath Nayakanti, Swati Dabral, Thomas Wunderlich, James Priest, Werner Seeger, Jörg Dötsch, Soni S. Pullamsetti, Miguel A. Alejandre Alcazar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
This study shows that maternal and perinatal obesity cause bronchial and vascular smooth muscle cell proliferation through an IL-6-FoxO1 axis, and favor thereby the emergence of bronchial obstruction and pulmonary hypertension later in life.
Externí odkaz:
https://doaj.org/article/b4419ac41c554af68c918ae4ee7c5d81
Autor:
Hebah A. Sindi, Giusy Russomanno, Sandro Satta, Vahitha B. Abdul-Salam, Kyeong Beom Jo, Basma Qazi-Chaudhry, Alexander J. Ainscough, Robert Szulcek, Harm Jan Bogaard, Claire C. Morgan, Soni S. Pullamsetti, Mai M. Alzaydi, Christopher J. Rhodes, Roberto Piva, Christina A. Eichstaedt, Ekkehard Grünig, Martin R. Wilkins, Beata Wojciak-Stothard
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Pulmonary arterial hypertension is a severe lung disease characterised by progressive vascular remodelling. Here, the authors show that reduced signalling of flow-activated transcription factor KLF2 is a common feature of human PAH and that KLF2-regu
Externí odkaz:
https://doaj.org/article/4eebb969beec4b25a1d7906be6c74e47
Autor:
Sevdalina Nikolova, Andreas Guenther, Rajkumar Savai, Norbert Weissmann, Hossein A. Ghofrani, Melanie Konigshoff, Oliver Eickelberg, Walter Klepetko, Robert Voswinckel, Werner Seeger, Friedrich Grimminger, Ralph T. Schermuly, Soni S. Pullamsetti
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/078778e3a92d4f6a8c0ccc3ce37c3a67
Autor:
Swati Dabral, Christian Muecke, Chanil Valasarajan, Mario Schmoranzer, Astrid Wietelmann, Gregg L. Semenza, Michael Meister, Thomas Muley, Tamina Seeger-Nukpezah, Christos Samakovlis, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Rajkumar Savai, Soni S. Pullamsetti
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypert
Externí odkaz:
https://doaj.org/article/a8901cfbf7474186b10f84b921b3e98d
Autor:
Stefan Kuhnert, Siavash Mansouri, Michael A. Rieger, Rajkumar Savai, Edibe Avci, Gabriela Díaz-Piña, Manju Padmasekar, Mario Looso, Stefan Hadzic, Till Acker, Stephan Klatt, Jochen Wilhelm, Ingrid Fleming, Natascha Sommer, Norbert Weissmann, Claus Vogelmeier, Robert Bals, Andreas Zeiher, Stefanie Dimmeler, Werner Seeger, Soni S. Pullamsetti
Publikováno v:
Cells, Vol 11, Iss 13, p 2121 (2022)
Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate p
Externí odkaz:
https://doaj.org/article/7e304d43b48b447aafd57d4483baf01e
Autor:
Argen Mamazhakypov, Astrid Weiß, Sven Zukunft, Akylbek Sydykov, Baktybek Kojonazarov, Jochen Wilhelm, Christina Vroom, Aleksandar Petrovic, Djuro Kosanovic, Norbert Weissmann, Werner Seeger, Ingrid Fleming, Marc Iglarz, Friedrich Grimminger, Hossein A. Ghofrani, Soni S. Pullamsetti, Ralph T. Schermuly
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Pulmonary arterial hypertension is a severe respiratory disease characterized by pulmonary artery remodeling. RV dysfunction and dysregulated circulating metabolomics are associated with adverse outcomes in pulmonary arterial hypertension. We investi
Externí odkaz:
https://doaj.org/article/f12a5a6e63d44ffdb2021cbce29d7c48
Autor:
Xiang Zheng, Siavash Mansouri, Annika Krager, Friedrich Grimminger, Werner Seeger, Soni S. Pullamsetti, Craig E. Wheelock, Rajkumar Savai
Publikováno v:
European Respiratory Review, Vol 29, Iss 157 (2020)
Lung cancer is the leading cause of death from cancer worldwide. Recent studies demonstrated that the tumour microenvironment (TME) is pivotal for tumour progression, providing multiple targeting opportunities for therapeutic strategies. As one of th
Externí odkaz:
https://doaj.org/article/03b5a88b24494b4999b2aad5db14a5e3
Autor:
Steffen Kiehl, Tobias Zimmermann, Rajkumar Savai, Soni S. Pullamsetti, Werner Seeger, Marek Bartkuhn, Reinhard H. Dammann
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation profiles of 480,000 CpGs in lung cancer cells were generated. It was observed that
Externí odkaz:
https://doaj.org/article/345716730072453da0e6f7e9e2f438eb
Autor:
Edda Spiekerkoetter, Elena A. Goncharova, Christophe Guignabert, Kurt Stenmark, Grazyna Kwapiszewska, Marlene Rabinovitch, Norbert Voelkel, Harm J. Bogaard, Brian Graham, Soni S. Pullamsetti, Wolfgang M. Kuebler
Publikováno v:
Pulmonary Circulation, Vol 9 (2019)
In order to intervene appropriately and develop disease-modifying therapeutics for pulmonary arterial hypertension, it is crucial to understand the mechanisms of disease pathogenesis and progression. We herein discuss four topics of disease mechanism
Externí odkaz:
https://doaj.org/article/626ec47683fb42e694eaf5c1bc80c757