Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Soni Lacefield"'
Publikováno v:
PLoS Genetics, Vol 19, Iss 4, p e1010707 (2023)
To prevent chromosome mis-segregation, a surveillance mechanism known as the spindle checkpoint delays the cell cycle if kinetochores are not attached to spindle microtubules, allowing the cell additional time to correct improper attachments. During
Externí odkaz:
https://doaj.org/article/268e0c7544b34840979cf9d2f4319e75
Autor:
Janardan N. Gavade, Soni Lacefield
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101797- (2022)
Summary: Simple genetic screens in budding yeast have identified many conserved meiotic regulators. However, the identification of genes involved in specific steps of meiosis may require a more complex genetic screen that allows visualization of meio
Externí odkaz:
https://doaj.org/article/c0434b1109134d2b96504cb47805702d
Autor:
Gregory S Barsh, Needhi Bhalla, Francesca Cole, Gregory P Copenhaver, Soni Lacefield, Diana E Libuda
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007649 (2018)
Externí odkaz:
https://doaj.org/article/c1a5c0384b184baca0bb599575c02dad
Publikováno v:
Cell Reports, Vol 9, Iss 6, Pp 2027-2033 (2014)
In many eukaryotes, the centromere is epigenetically specified and not strictly defined by sequence. In contrast, budding yeast has a specific 125 bp sequence required for kinetochore function. Despite the difference in centromere specification, budd
Externí odkaz:
https://doaj.org/article/2fa70e32c2d046c9a6932c6c6b8bf609
Autor:
Jill Elaine Falk, Dai Tsuchiya, Jolien Verdaasdonk, Soni Lacefield, Kerry Bloom, Angelika Amon
Publikováno v:
eLife, Vol 5 (2016)
In budding yeast, if the spindle becomes mispositioned, cells prevent exit from mitosis by inhibiting the mitotic exit network (MEN). The MEN is a signaling cascade that localizes to spindle pole bodies (SPBs) and activates the phosphatase Cdc14. The
Externí odkaz:
https://doaj.org/article/a50678422e8d4764b4c3bec08b152c19
Publikováno v:
PLoS Genetics, Vol 10, Iss 6, p e1004398 (2014)
In budding yeast, meiotic commitment is the irreversible continuation of the developmental path of meiosis. After reaching meiotic commitment, cells finish meiosis and gametogenesis, even in the absence of the meiosis-inducing signal. In contrast, if
Externí odkaz:
https://doaj.org/article/da0a4e39d3044b8694046ddeac41cc3e
Autor:
Soni Lacefield
Publikováno v:
eLife, Vol 1 (2012)
The prevention of premature interactions between microtubules and kinetochores is essential to ensuring that meiosis produces gametes with the correct number of chromosomes.
Externí odkaz:
https://doaj.org/article/602dfe00cb9a48e5b74d929798db5954
Proper chromosome segregation depends on establishment of bioriented kinetochore-microtubule attachments, which often requires multiple rounds of release and reattachment. Aurora B and C kinases phosphorylate kinetochore proteins to release tensionle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c6af746badf6848a882c329c256d96
https://doi.org/10.1101/2023.02.05.527197
https://doi.org/10.1101/2023.02.05.527197
To prevent chromosome mis-segregation, a surveillance mechanism known as the spindle checkpoint delays the cell cycle if kinetochores are not attached to spindle microtubules, allowing the cell additional time to correct improper attachments. During
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0d5b73de3ca2d49ebd1a22cfed5453f
https://doi.org/10.1101/2023.01.02.522494
https://doi.org/10.1101/2023.01.02.522494
Publikováno v:
Journal of visualized experiments : JoVE. (188)
Time-lapse fluorescence microscopy has revolutionized the understanding of meiotic cell-cycle events by providing temporal and spatial data that is often not seen by imaging fixed cells. Budding yeast has proved to be an important model organism to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a4516991bf749e822d34acf99830b05e
https://pubmed.ncbi.nlm.nih.gov/36314815
https://pubmed.ncbi.nlm.nih.gov/36314815