Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Songmao Zheng"'
Autor:
Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin‐Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, Simon A. Hinke
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 8, Pp 1431-1444 (2023)
Abstract Growth Differentiation Factor‐15 (GDF15) is a circulating polypeptide linked to cellular stress and metabolic adaptation. GDF15's half‐life is ~3 h and activates the glial cell line‐derived neurotrophic factor family receptor alpha‐l
Externí odkaz:
https://doaj.org/article/c585a6f12b244dfba472ff6c70f4a613
Autor:
Michelle A. Pressly, Lambertus A. Peletier, Songmao Zheng, Vishnu D. Sharma, Yi Ting (Kayla) Lien, Weirong Wang, Honghui Zhou, Stephan Schmidt
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 5, Pp 639-655 (2023)
Abstract The main objective of this tutorial is to provide the readers with a roadmap of how to establish increasingly complex target‐mediated drug disposition (TMDD) models for monoclonal antibodies. To this end, we built mathematical models, each
Externí odkaz:
https://doaj.org/article/26f7499bfef749dda8f7599767d5d989
Autor:
Xin Wang, Yan Li, Meng Sun, Jiping Zha, Songmao Zheng, Guizhong Liu, Peter Luo, John J Skinner, Kristine She, Jiangchun Xu, Felix Du
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/54d3ae910a7e49a8b32d88e170c68136
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 10, Pp 2355-2365 (2022)
Abstract Enhancing resiliency should elevate innovation and efficiency in biomedical research and development (R&D); however, compared with other professions, data on practice of resilience is lacking. Using the Benatti Resiliency Model (5 anchors: W
Externí odkaz:
https://doaj.org/article/9c09b966ff3b4a8e8f3456be000d0239
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 9, Pp 2096-2104 (2022)
Abstract Biologics are increasingly being co‐developed in combination or as novel constructs like bispecific antibodies (BsAbs) with the goal of targeting multiple, non‐redundant mechanisms of action. Rational design of combinations and dual‐ta
Externí odkaz:
https://doaj.org/article/ae37e1032b2d439ca81d90dac0679a18
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Biotherapeutic drugs against tumor necrosis factor (TNF) are effective treatments for moderate to severe inflammatory bowel disease (IBD). Here, we evaluated CNTO 5048, an antimurine TNF surrogate monoclonal antibody (mAb), in a CD45RBhigh adoptive T
Externí odkaz:
https://doaj.org/article/88dc0ad39bff48c0ae6be80ae381adac
Autor:
Songmao Zheng, Fang Shen, Brian Jones, Damien Fink, Brian Geist, Ivo Nnane, Zhao Zhou, Jeff Hall, Ravi Malaviya, Tatiana Ort, Weirong Wang
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Tumor necrosis factor (TNF) and interleukin (IL)-17A are pleiotropic cytokines implicated in the pathogenesis of several autoimmune diseases including rheumatoid arthritis (RA) and psoriatic arthritis (PsA). JNJ-61178104 is a novel human anti-TNF and
Externí odkaz:
https://doaj.org/article/14de5e65d91743cea20438bf02341a93
Autor:
Karen Brown, Shravani Etrouth, Priya Jayachandran, Jason Moore, Akinyemi Oni‐Orisan, Lakshmi Vasist, Songmao Zheng, Zhu Zhou, Mark Dresser
Publikováno v:
Clinical Pharmacology & Therapeutics. 113:483-485
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2c696a1daf166fd596df5a821b65a2d
https://doi.org/10.1002/cpt.2852
https://doi.org/10.1002/cpt.2852
Autor:
Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin‐Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, Simon A. Hinke
Publikováno v:
Clinical and Translational Science.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::807e129650b9209e577c3f657d7cfd4c
https://doi.org/10.1111/cts.13543
https://doi.org/10.1111/cts.13543
Autor:
Songmao Zheng, David Polidori, Yuanping Wang, Brian Geist, Xiefan Lin-Schmidt, Jennifer L. Furman, Serena Nelson, Andrea R. Nawrocki, Simon A. Hinke
GDF15 is a circulating polypeptide associated with cellular stress, and recently linked to metabolic adaptation. GDF15 has a half-life of approximately 3 hours in and acts at the GFRAL receptor selectively expressed in the area postrema. To character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88e026a2285071a87eb1de41ecc7ec4a
https://doi.org/10.1101/2022.12.05.519153
https://doi.org/10.1101/2022.12.05.519153
