Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Songlei Zhou"'
Autor:
Jianpei Xu, Yinzhe Sun, Yang You, Yuwen Zhang, Dan Huang, Songlei Zhou, Yipu Liu, Shiqiang Tong, Fenfen Ma, Qingxiang Song, Chengxiang Dai, Suke Li, Jigang Lei, Zhihua Wang, Xiaoling Gao, Jun Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1412-1427 (2024)
Mesenchymal stem cells (MSCs) experience substantial viability issues in the stroke infarct region, limiting their therapeutic efficacy and clinical translation. High levels of deadly reactive oxygen radicals (ROS) and proinflammatory cytokines (PC)
Externí odkaz:
https://doaj.org/article/0e37de5932ab4f14bd5a19106ea691b0
Autor:
Shiqiang Tong, Laozhi Xie, Xiaoying Xie, Jianpei Xu, Yang You, Yinzhe Sun, Songlei Zhou, Chuchu Ma, Gan Jiang, Fenfen Ma, Zhihua Wang, Xiaoling Gao, Jun Chen
Publikováno v:
Advanced Science, Vol 10, Iss 34, Pp n/a-n/a (2023)
Abstract Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Long‐term changes in the microenvironment of the brain contribute to the degeneration of neurological function following TBI. However, current research focu
Externí odkaz:
https://doaj.org/article/5be7b298194c42479a0d7b9e3572c11e
Autor:
Songlei Zhou, Yukun Huang, Yu Chen, Yipu Liu, Laozhi Xie, Yang You, Shiqiang Tong, Jianpei Xu, Gan Jiang, Qingxiang Song, Ni Mei, Fenfen Ma, Xiaoling Gao, Hongzhuan Chen, Jun Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Glioblastoma (GBM) is characterized by local and systemic immunosuppression, showing limited responses to immunotherapies. Here the authors describe the design of a nanoplatform composed of the lymphopenia alleviating agent cannabidiol and the lympho
Externí odkaz:
https://doaj.org/article/a48196460e1543ec91af235e4cfdaf60
Autor:
Tianze Jiang, Laozhi Xie, Songlei Zhou, Yipu Liu, Yukun Huang, Ni Mei, Fenfen Ma, Jingru Gong, Xiaoling Gao, Jun Chen
Publikováno v:
Journal of Nanobiotechnology, Vol 20, Iss 1, Pp 1-21 (2022)
Abstract Epithelial-mesenchymal transition (EMT), a differentiation process with aberrant changes of tumor cells, is identified as an initial and vital procedure for metastatic processes. Inflammation is a significant inducer of EMT and provides an i
Externí odkaz:
https://doaj.org/article/46841363a93649cf837e25c7a48a8bb5
Autor:
Minjun Xu, Kaili Hu, Yipu Liu, Yukun Huang, Shanshan Liu, Yu Chen, Dayuan Wang, Songlei Zhou, Qian Zhang, Ni Mei, Huiping Lu, Fengan Li, Xiaoling Gao, Jun Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Failure of conventional clinical therapies such as tumor resection and chemotherapy are mainly due to the ineffective control of tumor metastasis. Here, the authors show that a systemic metastasis-targeted nanotherapeutic may offer a powerful adjunct
Externí odkaz:
https://doaj.org/article/7a2d7bd07266424ab8d1204d7d93e358
Autor:
Yukun Huang, Yu Chen, Songlei Zhou, Liang Chen, Jiahao Wang, Yuanyuan Pei, Minjun Xu, Jingxian Feng, Tianze Jiang, Kaifan Liang, Shanshan Liu, Qingxiang Song, Gan Jiang, Xiao Gu, Qian Zhang, Xiaoling Gao, Jun Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The exclusion of cytotoxic T cells remains an important barrier to the efficacy of immunotherapies. Here the authors demonstrate that the combination anti-fibrosis agents and immune-enhanced cytokines can enhance T cell infiltration in a mouse model
Externí odkaz:
https://doaj.org/article/158cb6f07ed24ee38767bf2374a587c5
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 12, Iss 2, Pp 134-142 (2017)
PEGylated liposomes are potential candidates to improve the pharmacokinetic characteristics of encapsulated drugs, to extend their circulation half-life and facilitate their passive accumulation at tumour sites. However, PEG-modified liposomes can in
Externí odkaz:
https://doaj.org/article/3173bb1578fe484e8a5867b69b0ce263
Autor:
Yang You, Jianpei Xu, Yipu Liu, Haichun Li, Laozhi Xie, Chuchu Ma, Yinzhe Sun, Shiqiang Tong, Kaifan Liang, Songlei Zhou, Fenfen Ma, Qingxiang Song, Wenze Xiao, Kaikai Fu, Chengxiang Dai, Suke Li, Jigang Lei, Qiyong Mei, Xiaoling Gao, Jun Chen
Publikováno v:
ACS Nano. 17:8646-8662
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2f89582e0ec19d03d1d8f80977a476
https://doi.org/10.1021/acsnano.3c01497
https://doi.org/10.1021/acsnano.3c01497
Autor:
Shanshan Liu, Jianpei Xu, Yipu Liu, Yang You, Laozhi Xie, Shiqiang Tong, Yu Chen, Kaifan Liang, Songlei Zhou, Fengan Li, Zhuang Tang, Ni Mei, Huiping Lu, Xiaolin Wang, Xiaoling Gao, Jun Chen
Publikováno v:
ACS Applied Materials & Interfaces. 14:27743-27761
High level of detrimental factors including reactive oxygen species (ROS) and inflammatory cytokines accumulated in the infarct core and their erosion to salvageable penumbra are key pathological cascades of ischemia-reperfusion injury in stroke. Few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f623e9646f9e5a9db38f7fa42edd4058
https://doi.org/10.1021/acsami.2c09020
https://doi.org/10.1021/acsami.2c09020
Autor:
Tianze Jiang, Kaifan Liang, Jiahao Wang, Jun Chen, Qingxiang Song, Yu Chen, Xiao Gu, Liang Chen, Jingxian Feng, Xiaoling Gao, Yuanyuan Pei, Songlei Zhou, Minjun Xu, Shanshan Liu, Qian Zhang, Gan Jiang, Yukun Huang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
The failure of immunotherapies in immune-excluded tumor (IET) is largely ascribed to the void of intratumoral cytotoxic T cells (CTLs). The major obstacles are the excessive stroma, defective vasculatures and the deficiency of signals recruiting CTLs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90afff0c5aeb1f1d72ad579958f74a80
http://link.springer.com/article/10.1038/s41467-020-14425-7
http://link.springer.com/article/10.1038/s41467-020-14425-7