Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Songlei Liu"'
Autor:
Yuting Chen, Eriona Hysolli, Anlu Chen, Stephen Casper, Songlei Liu, Kevin Yang, Chenli Liu, George Church
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Whole-genome recoding has been shown to enable nonstandard amino acids, biocontainment and viral resistance in bacteria. Here the authors extend this to human cells using base editing to convert TAG to TAA for 33 essential genes via a single transfec
Externí odkaz:
https://doaj.org/article/4d4f5949126f4732aa4cc9b34be9ee16
Autor:
Elaine T. Lim, Yingleong Chan, Pepper Dawes, Xiaoge Guo, Serkan Erdin, Derek J. C. Tai, Songlei Liu, Julia M. Reichert, Mannix J. Burns, Ying Kai Chan, Jessica J. Chiang, Katharina Meyer, Xiaochang Zhang, Christopher A. Walsh, Bruce A. Yankner, Soumya Raychaudhuri, Joel N. Hirschhorn, James F. Gusella, Michael E. Talkowski, George M. Church
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Cerebral organoids can be used to gain insights into neuropsychiatric disorders. Here the authors carry out RNAseq characterization from organoids derived from donors with autism spectrum disorder to identify associated cell type specific driver gene
Externí odkaz:
https://doaj.org/article/95de5f4e0e584e9ba9efd47fbab020ce
Autor:
Songlei Liu, Johannes Striebel, Giovanni Pasquini, Alex H. M. Ng, Parastoo Khoshakhlagh, George M. Church, Volker Busskamp
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2021)
Gene activation with the CRISPR-Cas system has great implications in studying gene function, controlling cellular behavior, and modulating disease progression. In this review, we survey recent studies on targeted gene activation and multiplexed scree
Externí odkaz:
https://doaj.org/article/75507b52e26a4dcd9d24a861e8555c2a
Autor:
Huadong Ni, Miao Xu, Keyue Xie, Yong Fei, Housheng Deng, Qiuli He, Tingting Wang, Songlei Liu, Jianjun Zhu, Longsheng Xu, Ming Yao
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Bone cancer pain (BCP) is an intractable clinical problem, and lacked effective drugs for treating it. Recent research showed that several chemokines in the spinal cord are involved in the pathogenesis of BCP. In this study, the antinociceptive effec
Externí odkaz:
https://doaj.org/article/04453232874649b6a9c9e2fa89760dd8
Publikováno v:
Pain Research and Management, Vol 2020 (2020)
Background. Primary V1 trigeminal neuralgia is a common refractory neuralgia in clinical practice, lacking effective treatments. Radiofrequency therapy has certain treatment efficacy, but its long-term efficacy remained poor and the disease might rel
Externí odkaz:
https://doaj.org/article/295f221e878447af98332047e8d9fa73
Publikováno v:
Pain Research and Management, Vol 2020 (2020)
Background. Radiofrequency of the Gasserian ganglion can be used for ophthalmic herpetic neuralgia (OHN), but it is associated with complications. This study aimed to use the supraorbital nerve for computed tomography- (CT-) guided radiofrequency the
Externí odkaz:
https://doaj.org/article/ff1949e39d5f4b45aa3bc978b255b944
Autor:
Christian Kramme, Merrick Smela, Bennett Wolf, Patrick Fortuna, Garyk Brixi, Tian-Lai Zang, Sophia Vincoff, Kalyan Palepu, Sabrina Koseki, Suhaas Bhat, Edward Dong, Jessica Adams, Richie Kohman, Songlei Liu, Mutsumi Kobayashi, Toshihiro Shioda, George Church, Pranam Chatterjee
The generation of germline cell types from human induced pluripotent stem cells (hiPSCs) represents a key milestone toward in vitro gametogenesis, which has the potential to transform reproductive medicine. Methods to recapitulate germline cell speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8d320dd383bf6646ac1162e92d06ffe
https://doi.org/10.21203/rs.3.rs-2652895/v1
https://doi.org/10.21203/rs.3.rs-2652895/v1
Autor:
Mark A. Skylar-Scott, Jeremy Y. Huang, Aric Lu, Alex H. M. Ng, Tomoya Duenki, Songlei Liu, Lucy L. Nam, Sarita Damaraju, George M. Church, Jennifer A. Lewis
Publikováno v:
Nat Biomed Eng
The generation of organoids and tissues with programmable cellular complexity, architecture and function would benefit from the simultaneous differentiation of human induced pluripotent stem cells (hiPSCs) into divergent cell types. Yet differentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c310e7f49d6f909e1ff0ef0b0d526f8b
https://doi.org/10.1038/s41551-022-00856-8
https://doi.org/10.1038/s41551-022-00856-8
The creation of induced pluripotent stem cells (iPSCs) has enabled scientists to explore the derivation of many types of cells. While there are diverse general approaches for cell-fate engineering, one of the fastest and most efficient approaches is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a72b16e316c9e38de0e35fe02dbf5f1
https://doi.org/10.1101/2022.10.14.512279
https://doi.org/10.1101/2022.10.14.512279
Autor:
Christian Kramme, Merrick Pierson Smela, Bennett Wolf, Patrick R. Fortuna, Garyk Brixi, Kalyan Palepu, Edward Dong, Jessica Adams, Suhaas Bhat, Sabrina Koseki, Emma Tysinger, Teodora Stan, Richie E. Kohman, Songlei Liu, Mutsumi Kobayashi, Toshi Shioda, George M. Church, Pranam Chatterjee
Germ cells are the vehicle of human reproduction, arising early in embryonic development and developing throughout adult life until menopause onset in women. Primordial germ cells are the common precursors of germline cells in both sexes, undergoing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78399c385496240d7b43a843abfc1fb9
https://doi.org/10.1101/2022.07.11.499564
https://doi.org/10.1101/2022.07.11.499564