Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Song-Iee Han"'
Autor:
Nurani Istiqamah, Takashi Matsuzaka, Momo Shimizu, Kaori Motomura, Hiroshi Ohno, Shiho Hasebe, Rahul Sharma, Yuka Okajima, Erika Matsuda, Song-Iee Han, Yuhei Mizunoe, Yoshinori Osaki, Yuichi Aita, Hiroaki Suzuki, Hirohito Sone, Yoshinori Takeuchi, Motohiro Sekiya, Naoya Yahagi, Yoshimi Nakagawa, Hitoshi Shimano
Publikováno v:
BBA Advances, Vol 3, Iss , Pp 100078- (2023)
ELOVL fatty acid elongase 6 (ELOVL6) controls cellular fatty acid (FA) composition by catalyzing the elongation of palmitate (C16:0) to stearate (C18:0) and palmitoleate (C16:1n-7) to vaccinate (C18:1n-7). Although the transcriptional regulation of E
Externí odkaz:
https://doaj.org/article/e84f1df2553c4b24a2be747d4eb7ed82
Autor:
Yoshimi Nakagawa, Yunong Wang, Song-iee Han, Kanako Okuda, Asayo Oishi, Yuka Yagishita, Kae Kumagai, Hiroshi Ohno, Yoshinori Osaki, Yuhei Mizunoe, Masaya Araki, Yuki Murayama, Hitoshi Iwasaki, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 949-971 (2021)
Background & Aims: cAMP responsive element-binding protein 3 like 3 (CREB3L3) is a membrane-bound transcription factor involved in the maintenance of lipid metabolism in the liver and small intestine. CREB3L3 controls hepatic triglyceride and glucose
Externí odkaz:
https://doaj.org/article/bce56fc30a3344359dbfa3a4b2fbc9ba
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100721- (2021)
Summary: Disruption of mitochondrial morphology occurs during various diseases, but the biological significance is not entirely clear. Here, we describe a detailed step-by-step protocol for a chemically inducible dimerization system-based synthetic p
Externí odkaz:
https://doaj.org/article/7a297c7a7cd949ce8e313a840a3d9aa8
Autor:
Takafumi Miyamoto, Hideki Uosaki, Yuhei Mizunoe, Song-Iee Han, Satoi Goto, Daisuke Yamanaka, Masato Masuda, Yosuke Yoneyama, Hideki Nakamura, Naoko Hattori, Yoshinori Takeuchi, Hiroshi Ohno, Motohiro Sekiya, Takashi Matsuzaka, Fumihiko Hakuno, Shin-Ichiro Takahashi, Naoya Yahagi, Koichi Ito, Hitoshi Shimano
Publikováno v:
Cell Reports: Methods, Vol 1, Iss 4, Pp 100052- (2021)
Summary: Engineered synthetic biomolecular devices that integrate elaborate information processing and precisely regulate living cell behavior have potential in various applications. Although devices that directly regulate key biomolecules constituti
Externí odkaz:
https://doaj.org/article/75ae182478b64fe69033777691d2582b
Autor:
Aoi Satoh, Song-iee Han, Masaya Araki, Yoshimi Nakagawa, Hiroshi Ohno, Yuhei Mizunoe, Kae Kumagai, Yuki Murayama, Yoshinori Osaki, Hitoshi Iwasaki, Motohiro Sekiya, Morichika Konishi, Nobuyuki Itoh, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano
Publikováno v:
iScience, Vol 23, Iss 3, Pp - (2020)
Summary: Mice overexpressing the nuclear form of CREBH mainly in the liver (CREBH-Tg) showed suppression of high-fat high-sucrose (HFHS) diet-induced obesity accompanied by an increase in plasma fibroblast growth factor 21 (FGF21) levels. CREBH overe
Externí odkaz:
https://doaj.org/article/d7967aadf1e240c7bf75f7b3a6059d4c
Autor:
Kenta Takei, Yoshimi Nakagawa, Yunong Wang, Song-iee Han, Aoi Satoh, Motohiro Sekiya, Takashi Matsuzaka, Hitoshi Shimano
Publikováno v:
Journal of Pharmacological Sciences, Vol 133, Iss 4, Pp 214-222 (2017)
Peroxisome proliferator-activated receptor α (PPARα) is a well-known therapeutic target for treating hyperlipidemia. K-877 is a novel selective PPARα modulator (SPPARMα) that enhances PPARα transcriptional activity with high selectivity and pote
Externí odkaz:
https://doaj.org/article/9c05bbaff22f42bcb39530e3ff03cd89
Autor:
Takuya Kikuchi, Kana Orihara, Fusaka Oikawa, Song-iee Han, Motoko Kuba, Kanako Okuda, Aoi Satoh, Yoshinori Osaki, Yoshinori Takeuchi, Yuichi Aita, Takashi Matsuzaka, Hitoshi Iwasaki, Shigeru Yatoh, Motohiro Sekiya, Naoya Yahagi, Hiroaki Suzuki, Hirohito Sone, Yoshimi Nakagawa, Nobuhiro Yamada, Hitoshi Shimano
Publikováno v:
Molecular Metabolism, Vol 5, Iss 11, Pp 1092-1102 (2016)
Objective: The transcription factor cyclic AMP-responsive element-binding protein H (CREBH, encoded by Creb3l3) is highly expressed in the liver and small intestine. Hepatic CREBH contributes to glucose and triglyceride metabolism by regulating fibro
Externí odkaz:
https://doaj.org/article/9e58a6d6bc0d4359b17de122760090cb
Autor:
Shohei Oie, Kazuya Matsuzaki, Wataru Yokoyama, Shinji Tokunaga, Tsuyoshi Waku, Song-Iee Han, Naoya Iwasaki, Aya Mikogai, Kayoko Yasuzawa-Tanaka, Hiroyuki Kishimoto, Hiromi Hiyoshi, Yuka Nakajima, Toshiyuki Araki, Keiji Kimura, Junn Yanagisawa, Akiko Murayama
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 807-820 (2014)
Ribosome biosynthesis is a major intracellular energy-consuming process. We previously identified a nucleolar factor, nucleomethylin (NML), which regulates intracellular energy consumption by limiting rRNA transcription. Here, we show that, in livers
Externí odkaz:
https://doaj.org/article/de20f559a30e484c88f75979f11e7779
Autor:
Noriko Suzuki-Kemuriyama, Takashi Matsuzaka, Motoko Kuba, Hiroshi Ohno, Song-Iee Han, Yoshinori Takeuchi, Masaaki Isaka, Kazuto Kobayashi, Hitoshi Iwasaki, Shigeru Yatoh, Hiroaki Suzuki, Katsuhiro Miyajima, Dai Nakae, Naoya Yahagi, Yoshimi Nakagawa, Hirohito Sone, Nobuhiro Yamada, Hitoshi Shimano
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157580 (2016)
Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver damage, such as that from liver cirrhosis and cancer. Recent studies have shown the benefits of cons
Externí odkaz:
https://doaj.org/article/ba72cf7df6544c9194ad881ba3772ffe
Autor:
Masaya Araki, Yoshimi Nakagawa, Hodaka Saito, Yasunari Yamada, Song-Iee Han, Yuhei Mizunoe, Hiroshi Ohno, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 323:G627-G639
Hepatocyte- and macrophage-specific SREBP-1a knockout mice were generated for the first time. This study reveals that SREBP-1a does not contribute to hepatic lipogenesis, but in either hepatocytes or macrophages distinctly controls the onset of patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688d3e66dd33e69db78b7beb07ddf280
https://doi.org/10.1152/ajpgi.00090.2022
https://doi.org/10.1152/ajpgi.00090.2022