Zobrazeno 1 - 10
of 373
pro vyhledávání: '"Song Guo, Zheng"'
Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis
Autor:
Jian Chen, Deping Zhao, Yupeng Wang, Ming Liu, Yuan Zhang, Tingting Feng, Chao Xiao, Huan Song, Rui Miao, Li Xu, Hongwei Chen, Xiaoying Qiu, Yi Xu, Jingxuan Xu, Zelin Cui, Wei Wang, Yanchun Quan, Yifeng Zhu, Chen Huang, Song Guo Zheng, Jian‐yuan Zhao, Ting Zhu, Lianhui Sun, Guangjian Fan
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Mortality rates due to lung cancer are high worldwide. Although PD‐1 and PD‐L1 immune checkpoint inhibitors boost the survival of patients with non‐small‐cell lung cancer (NSCLC), resistance often arises. The Warburg Effect, which ca
Externí odkaz:
https://doaj.org/article/88d173ca899746b58f577c26b1255723
Autor:
Jun Zhao, Yan Liu, Xiaoyi Shi, Junlong Dang, Yu Liu, Siwen Li, Wei Cai, Yuluan Hou, Donglan Zeng, Ye Chen, Jia Yuan, Yiding Xiong, Wenbin Wu, Peihong Cai, Jingrong Chen, Jianbo Sun, Yiming Shao, David D. Brand, Song Guo Zheng
Publikováno v:
Journal of Advanced Research, Vol 58, Iss , Pp 79-91 (2024)
Introduction: Rheumatoid arthritis (RA) is a systemic autoimmune disease with limited treatment success, characterized by chronic inflammation and progressive cartilage and bone destruction. Accumulating evidence has shown that neutrophil extracellul
Externí odkaz:
https://doaj.org/article/7729666ce71941bbae1cf00e7628ce18
Epithelial SIRT6 governs IL-17A pathogenicity and drives allergic airway inflammation and remodeling
Autor:
Jingyun Quan, Xiaoxia Wen, Guomei Su, Yu Zhong, Tong Huang, Zhilin Xiong, Jiewen Huang, Yingying Lv, Shihai Li, Shuhua Luo, Chaole Luo, Xin Cai, Xianwen Lai, Yuanyuan Xiang, Song Guo Zheng, Yiming Shao, Haitao Lin, Xiao Gao, Jing Tang, Tianwen Lai
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Dysregulation of IL-17A is closely associated with airway inflammation and remodeling in severe asthma. However, the molecular mechanisms by which IL-17A is regulated remain unclear. Here we identify epithelial sirtuin 6 (SIRT6) as an epigen
Externí odkaz:
https://doaj.org/article/e3a288d3476c4dd08ea3736c3ba24a6a
Autor:
Qiannan Fang, Wenbin Wu, Zexiu Xiao, Donglan Zeng, Rongzhen Liang, Julie Wang, Jia Yuan, Wenru Su, Xiang Xu, Yue Zheng, Tianwen Lai, Jianbo Sun, Qingling Fu, Song Guo Zheng
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109818- (2024)
Summary: Allergic asthma is a chronic non-communicable disease characterized by lung tissue inflammation. Current treatments can alleviate the clinical symptoms to some extent, but there is still no cure. Recently, the transplantation of mesenchymal
Externí odkaz:
https://doaj.org/article/edd7b6bbd27b4bf8b45a92918cc56f0c
Publikováno v:
Rheumatology & Autoimmunity, Vol 3, Iss 2, Pp 90-99 (2023)
Abstract Background Gingiva‐derived mesenchymal stem cells (GMSCs) suppress immune and inflammatory responses in experimental arthritis models. Here, we determined whether GMSCs suppress the proliferation and invasion of rheumatoid arthritis fibrob
Externí odkaz:
https://doaj.org/article/2b565a46a24a43608a084bb97b8a2c3b
Autor:
Yan Liu, Xiqing Luo, Ye Chen, Junlong Dang, Donglan Zeng, Xinghua Guo, Weizhen Weng, Jun Zhao, Xiaoyi Shi, Jingrong Chen, Bo Dong, Shuyuan Zhong, Jianhua Ren, Yuhang Li, Julie Wang, Jingwen Zhang, Jianbo Sun, Hanshi Xu, Yan Lu, David Brand, Song Guo Zheng, Yunfeng Pan
Publikováno v:
Redox Biology, Vol 69, Iss , Pp 103008- (2024)
Focal iron overload is frequently observed in patients with rheumatoid arthritis (RA), yet its functional significance remains elusive. Herein, we report that iron deposition in lesion aggravates arthritis by inducing macrophage ferroptosis. We show
Externí odkaz:
https://doaj.org/article/531b221b3349458ab81a129d10c4b3ae
Autor:
Zhigang Chen, Rong Fan, Jie Liang, Zexiu Xiao, Junlong Dang, Jun Zhao, Ruihui Weng, Cansheng Zhu, Song Guo Zheng, Ying Jiang
Publikováno v:
Journal of Advanced Research, Vol 39, Iss , Pp 225-235 (2022)
Introduction: The transcription factor NFIL3 exerts comprehensive effects on the immune system. Previous studies revealed that NFIL3 is related to the function and development of different immune cell subsets. Experimental autoimmune encephalomyeliti
Externí odkaz:
https://doaj.org/article/2a47c3189fc449b4b16b36d2dcc76c7f
Autor:
Myung-Chul Kim, Nicholas Borcherding, Kawther K. Ahmed, Andrew P. Voigt, Ajaykumar Vishwakarma, Ryan Kolb, Paige N. Kluz, Gaurav Pandey, Umasankar De, Theodore Drashansky, Eric Y. Helm, Xin Zhang, Katherine N. Gibson-Corley, Julia Klesney-Tait, Yuwen Zhu, Jinglu Lu, Jinsong Lu, Xian Huang, Hongrui Xiang, Jinke Cheng, Dongyang Wang, Zheng Wang, Jian Tang, Jiajia Hu, Zhengting Wang, Hua Liu, Mingjia Li, Haoyang Zhuang, Dorina Avram, Daohong Zhou, Rhonda Bacher, Song Guo Zheng, Xuefeng Wu, Yousef Zakharia, Weizhou Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Regulatory T (Treg) cells are important modulators of the tumor microenvironment. Here the authors perform transcriptome profiling of immune cells from patients with renal clear cell carcinoma to find a Treg signature that correlates with poorer prog
Externí odkaz:
https://doaj.org/article/ce7f282daf59489b9f1d9368f3849b81
Autor:
Ryan Kolb, Umasankar De, Sajid Khan, Yuewan Luo, Myung-Chul Kim, Haijun Yu, Chaoyan Wu, Jiao Mo, Xin Zhang, Peiyi Zhang, Xuan Zhang, Nicholas Borcherding, Daniel Koppel, Yang-Xin Fu, Song Guo Zheng, Dorina Avram, Guangrong Zheng, Daohong Zhou, Weizhou Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Targeting regulatory T cells (Treg) represents a therapeutic option to abrogate tumor-associated immune suppression. Here the authors show that pharmacological degradation of BCL-XL preferentially induces apoptosis of tumor-infiltrating Treg, promoti
Externí odkaz:
https://doaj.org/article/11696984783a45a99be93e6ba397acf8
Autor:
Weiqian Chen, Weishan Huang, Youqiu Xue, Ye Chen, Wenbin Qian, Jilin Ma, Avery August, Julie Wang, Song Guo Zheng, Jin Lin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
CD4+Foxp3+ regulatory T cells (Tregs) play a crucial role in preventing autoimmunity and inflammation. There are naturally-derived in the thymus (tTreg), generated extrathymically in the periphery (pTreg), and induced in vitro culture (iTreg) with di
Externí odkaz:
https://doaj.org/article/14a322d8a4be4f139e36807b250349db