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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.

Autor: He S; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States. Electronic address: shuwen@kallyope.com., Lai Z; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Hong Q; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Shang J; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Reibarkh M; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Kuethe JT; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Liu J; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Guiadeen D; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Krikorian AD; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Cernak TA; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Dykstra KD; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Sperbeck DM; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Wu Z; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Yu Y; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Yang GX; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Jian T; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Verras A; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Sonatore LM; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Wiltsie J; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Chung CC; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Murphy BA; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Gorski JN; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Liu J; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Xiao J; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Wolff M; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Tong SX; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Madeira M; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Karanam BV; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Shen DM; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Balkovec JM; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Pinto S; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., Nargund RP; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States., DeVita RJ; Merck & Co., Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2019 May 15; Vol. 29 (10), pp. 1182-1186. Date of Electronic Publication: 2019 Mar 21.

Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.

Autor: Zhang T; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Liu Y; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Yang X; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Martin GE; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Yao H; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Shang J; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Bugianesi RM; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Ellsworth KP; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Sonatore LM; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Nizner P; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Sherer EC; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Hill SE; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Knemeyer IW; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Geissler WM; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Dandliker PJ; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Helmy R; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Wood HB; Department of Medicinal Chemistry, ‡Department of Process and Analytical Chemistry, and ¶Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc. , PO Box 2000, Rahway, New Jersey 07065, United States.; Department of Pharmacology and ⊥Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, and §Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc. , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Mar 10; Vol. 59 (5), pp. 1818-29. Date of Electronic Publication: 2016 Feb 22.

Development of a novel tricyclic class of potent and selective FIXa inhibitors.

Autor: Meng D; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. Electronic address: dongfang-meng@merck.com., Andre P; Department of Cardiometabolic Disease, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Bateman TJ; Department of Pharmacokinetics, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Berger R; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Chen YH; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Desai K; Department of Cardiometabolic Disease, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Dewnani S; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Ellsworth K; Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Feng D; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Geissler WM; Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Guo L; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Hruza A; Department of Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Jian T; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Li H; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Metzger J; Department of Cardiometabolic Disease, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Parker DL; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Reichert P; Department of Structural Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Sherer EC; Department of Chemistry Modeling and Informatics, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Smith CJ; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Sonatore LM; Department of Pharmacology, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Tschirret-Guth R; Department of Pharmacokinetics, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Wu J; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Xu J; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Zhang T; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Campeau LC; Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Orr R; Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Poirier M; Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., McCabe-Dunn J; Department of Process Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA., Araki K; Discovery Research, Mochida Pharmaceutical Co., LTD, 7, Yotsuya 1-Chome, Shinjuku-ku, Tokyo 160-8515, Japan., Nishimura T; Discovery Research, Mochida Pharmaceutical Co., LTD, 7, Yotsuya 1-Chome, Shinjuku-ku, Tokyo 160-8515, Japan., Sakurada I; Discovery Research, Mochida Pharmaceutical Co., LTD, 7, Yotsuya 1-Chome, Shinjuku-ku, Tokyo 160-8515, Japan., Hirabayashi T; Discovery Research, Mochida Pharmaceutical Co., LTD, 7, Yotsuya 1-Chome, Shinjuku-ku, Tokyo 160-8515, Japan., Wood HB; Department of Discovery Chemistry, Merck Research Laboratories, Merck & Co., Inc., PO Box 2000, Rahway, NJ 07065, USA.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Nov 15; Vol. 25 (22), pp. 5437-43. Date of Electronic Publication: 2015 Jul 31.

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.

Autor: He S; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Hong Q; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Lai Z; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Yang DX; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Ting PC; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Kuethe JT; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Cernak TA; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Dykstra KD; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Sperbeck DM; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Wu Z; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Yu Y; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Yang GX; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Jian T; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Liu J; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Guiadeen D; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Krikorian AD; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Sonatore LM; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Wiltsie J; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Liu J; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Gorski JN; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Chung CC; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Gibson JT; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Lisnock J; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Xiao J; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Wolff M; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Tong SX; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Madeira M; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Karanam BV; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Shen DM; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Balkovec JM; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Pinto S; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., Nargund RP; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States., DeVita RJ; Early Development and Discovery Sciences, Merck Research Laboratories , 2000 Galloping Hill Road, Kenilworth, New Jersey 07033, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2014 Sep 08; Vol. 5 (10), pp. 1082-7. Date of Electronic Publication: 2014 Sep 08 (Print Publication: 2014).