Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward

Autor: Richard A. Slivicki, Vishakh Iyer, Sonali S. Mali, Sumanta Garai, Ganesh A. Thakur, Jonathon D. Crystal, Andrea G. Hohmann

Publikováno v: Frontiers in Molecular Neuroscience, Vol 13 (2020)

Opioid analgesics represent a critical treatment for chronic pain in the analgesic ladder of the World Health Organization. However, their use can result in a number of unwanted side-effects including incomplete efficacy, constipation, physical depen

Externí odkaz: https://doaj.org/article/fdca151317774c32b3e7e90819757de9

Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs

Autor: Stephen G. Brohawn, Jonathan P Remis, Sonali S Mali, Savitha Sridharan, Abhay Kotecha, Ben Sorum, David M Kern, Daniel B Toso, Christopher M Hoel, Diana M. Bautista

Publikováno v: Nat Struct Mol Biol
Nature structural & molecular biology, vol 28, iss 7
Nature Structural & Molecular Biology

SARS-CoV-2 ORF3a is a putative viral ion channel implicated in autophagy inhibition, inflammasome activation, and apoptosis. 3a protein and anti-3a antibodies are found in infected patient tissues and plasma. 3a deletion in SARS-CoV-1 reduces viral t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592744c7f9f4aa34f4dcad1c91504653
https://europepmc.org/articles/PMC8772433/

Cryo-EM structure of the SARS-CoV-2 3a ion channel in lipid nanodiscs

Autor: Savitha Sridharan, Stephen G. Brohawn, Ben Sorum, Christopher M Hoel, Diana M. Bautista, Daniel B. Toso, David M Kern, Sonali S Mali, Jonathan P Remis, Abhay Kotecha

Publikováno v: bioRxiv
article-version (status) pre
article-version (number) 1

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes the coronavirus disease 2019 (COVID-19). SARS-CoV-2 encodes three putative ion channels: E, 8a, and 3a1,2. 3a is expressed in SARS patient tissue and anti-3a antibo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b937d5aa66f8b344a825c17d3eb9494
https://doi.org/10.1101/2020.06.17.156554

Voluntary exercise reduces both chemotherapy-induced neuropathic nociception and deficits in hippocampal cellular proliferation in a mouse model of paclitaxel-induced peripheral neuropathy

Autor: Andrea G. Hohmann, Sonali S. Mali, Richard A. Slivicki

Publikováno v: Neurobiology of Pain

Highlights • Paclitaxel treatment did not alter voluntary running activity. • Voluntary running reduced mechanical and cold allodynia induced by paclitaxel. • Voluntary running reduced paclitaxel-induced deficits in hippocampal cellular prolife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ca2ee664dae5a0cd9c8a3ee74eb372
https://pubmed.ncbi.nlm.nih.gov/31528755

Label-Free Nanoplasmonic-Based Short Noncoding RNA Sensing at Attomolar Concentrations Allows for Quantitative and Highly Specific Assay of MicroRNA-10b in Biological Fluids and Circulating Exosomes.

Autor: Joshi GK; Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis , 402 North Blackford Street, LD 326, Indianapolis, Indiana 46202, United States., Deitz-McElyea S; Departments of Medicine, and Biochemistry and Molecular Biology, the Indiana University Simon Cancer Center, and the Pancreatic Cancer Signature Center, Indiana University School of Medicine , 980 West Walnut Street, R3-C528, Indianapolis, Indiana 46202, United States., Liyanage T; Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis , 402 North Blackford Street, LD 326, Indianapolis, Indiana 46202, United States., Lawrence K; Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis , 402 North Blackford Street, LD 326, Indianapolis, Indiana 46202, United States., Mali S; Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis , 402 North Blackford Street, LD 326, Indianapolis, Indiana 46202, United States., Sardar R; Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis , 402 North Blackford Street, LD 326, Indianapolis, Indiana 46202, United States.; Integrated Nanosystems Development Institute, Indiana University-Purdue University Indianapolis , 402 North Blackford Street, Indianapolis, Indiana 46202, United States., Korc M; Departments of Medicine, and Biochemistry and Molecular Biology, the Indiana University Simon Cancer Center, and the Pancreatic Cancer Signature Center, Indiana University School of Medicine , 980 West Walnut Street, R3-C528, Indianapolis, Indiana 46202, United States.

Publikováno v: ACS nano [ACS Nano] 2015 Nov 24; Vol. 9 (11), pp. 11075-89. Date of Electronic Publication: 2015 Oct 07.