Biomarkers of systemic inflammation provide additional prognostic stratification in cancers of unknown primary

Autor: Svenja Harvey, Mark Stares, Julie‐Anne Scott, Tharun Joseph Vattam Thottiyil, Alicia‐Marie Conway, Rachel Haigh, Jackie Brown, Gillian Knowles, Sonali Dasgupta, Kai‐Keen Shiu, Claire Mitchell, Colin Barrie, Natalie Cook, Sally Clive

Publikováno v: Cancer Medicine, Vol 13, Iss 3, Pp n/a-n/a (2024)

Abstract Background Biomarkers of systemic inflammation have been shown to predict outcomes in patients with cancer of unknown primary (CUP). We sought to validate these findings in patients with confirmed CUP (cCUP) and explore their role alongside

Externí odkaz: https://doaj.org/article/c5055b489f1a43e8828eba5e72f48749

Supplementary Table ST2 from A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer

Autor: Jochen H.M. Prehn, Markus Rehm, Daniel B. Longley, Bryan T. Hennessy, Sandra Van Schaeybroeck, Pierre Laurent-Puig, Elaine W. Kay, Deborah A. McNamara, Manuel Salto-Tellez, Sophie Camilleri-Broët, Richard Wilson, Patrick G. Johnston, Mark Lawler, Sinead Toomey, Lisa M. Schöller, Elisabeth Zink, Camilla Pilati, Nadege Rice, Sonali Dasgupta, Lorna Flanagan, Robert O'Byrne, Áine C. Murphy, Alexa J. Resler, Orna Bacon, Andreas U. Lindner, Mattia Cremona, Sarah Curry, Clare Morgan, Maximilian L. Würstle, Manuela Salvucci

Unadjusted and multivariate Cox proportional hazards analyses to examine the association of APOPTO-CELL and APOPTO-CELL-PC3 signatures with DFS in n=157 stage III patients of the expansion cohort.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0401b46937d32b10574be283b4f4e5d9
https://doi.org/10.1158/1078-0432.22467290.v1

Supplementary Methods SM2 from A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer

Autor: Jochen H.M. Prehn, Markus Rehm, Daniel B. Longley, Bryan T. Hennessy, Sandra Van Schaeybroeck, Pierre Laurent-Puig, Elaine W. Kay, Deborah A. McNamara, Manuel Salto-Tellez, Sophie Camilleri-Broët, Richard Wilson, Patrick G. Johnston, Mark Lawler, Sinead Toomey, Lisa M. Schöller, Elisabeth Zink, Camilla Pilati, Nadege Rice, Sonali Dasgupta, Lorna Flanagan, Robert O'Byrne, Áine C. Murphy, Alexa J. Resler, Orna Bacon, Andreas U. Lindner, Mattia Cremona, Sarah Curry, Clare Morgan, Maximilian L. Würstle, Manuela Salvucci

Detailed description of the measurements used as inputs for the apoptosis-based signatures in the discovery, expansion and validation cohorts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381fd3d22f1e2460d3f4192c76b832f9
https://doi.org/10.1158/1078-0432.22467299.v1

Stratification of chemotherapy-treated stage III colorectal cancer patients using multiplexed imaging and single-cell analysis of T-cell populations

Autor: Jochen H M Prehn, Andreas U. Lindner, Mark Lawler, Jonathan R. Owens, Xanthi Stachtea, Fiona Ginty, Corwin Alex D, John Frederick Graf, Pierre Laurent-Puig, Elizabeth McDonough, Sanghee Cho, Manuela Salvucci, Anup Sood, Samantha Abate, Daniel B. Longley, Sonali Dasgupta, Alberto Santamaria-Pang, Sandra Van Schaeybroeck, Maurice B Loughrey, Jinru Shia

Publikováno v: Stachtea, X, Loughrey, M B, Salvucci, M, Lindner, A U, Cho, S, McDonough, E, Sood, A, Graf, J, Santamaria-Pang, A, Corwin, A, Laurent-Puig, P, Dasgupta, S, Shia, J, Owens, J R, Abate, S, Van Schaeybroeck, S, Lawler, M, Prehn, J H M, Ginty, F & Longley, D B 2021, ' Stratification of chemotherapy-treated stage III colorectal cancer patients using multiplexed imaging and single-cell analysis of T-cell populations ', Modern Pathology . https://doi.org/10.1038/s41379-021-00953-0

Colorectal cancer (CRC) has one of the highest cancer incidences and mortality rates. In stage III, postoperative chemotherapy benefits

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21894d01613c8f5e16bad80253d39841
https://doi.org/10.1038/s41379-021-00953-0

Integration of a patient-centred MUO/CUP service within a new acute oncology service: challenges and rewards

Autor: Sonali Dasgupta, Adam Henry, Conn Haughey, Sohail Mughal, Wendy B Hyland, Celia Diver-Hall

Publikováno v: Future Healthc J

BACKGROUND: Holistic approach to the clinical management pathway for malignancy of undefined primary origin (MUO)/carcinoma of unknown primary (CUP) patients remains an unmet clinical need. To address this, an MUO/CUP service was implemented during c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b707ad13999013c0a407ef8b9bed891
https://doi.org/10.7861/fhj.2020-0044