Výsledky vyhledávání - "Sonali A. C. Herath"

The cancer testis antigens CABYR-a/b and CABYR-c are expressed in a subset of colorectal cancers and hold promise as targets for specific immunotherapy

Autor: Richard L Whelan, Vesna Cekic, Elie Sutton, Xiaohong Yan, H M C Shantha Kumara, Daniel Kirchoff, Sonali A C Herath, Linda Njoh, Aqeel Ahmed, Otavia L. Caballero, Tao Su

Publikováno v: Oncotarget

Introduction Calcium-binding tyrosine phosphorylation-regulated protein (CABYR) is expressed in the human germ line but not in adult human tissues, thus, it is considered a cancer testis protein. The aim of this study is to evaluate the CABYR isoform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f183a958fd84e9d29313d669b182ae
http://europepmc.org/articles/PMC7939523

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Expression of the cancer testis antigen IGF2BP3 in colorectal cancers; IGF2BP3 holds promise as a specific immunotherapy target

Autor: Andrew J. G. Simpson, Richard L. Whelan, Otavia L. Caballero, Aqeel Ahmed, Daniel Kirchoff, Tao Su, Linda Njoh, Hmc Shantha Kumara, Carlos Cordon-Cardo, Sonali A. C. Herath, Vesna Cekic

Publikováno v: Oncoscience

Introduction IGF2BP3 (IMP3) is a mRNA binding protein that regulates IGF2 translation and function during embryogenesis. Because IGF2BP3 is undetectable in adult human tissues except the testis, and increased IGF2BP3 expression has been noted in seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7856873e41f5b90cbe43619e9432ae
http://europepmc.org/articles/PMC4506364

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Minimally invasive colorectal resection is associated with significantly elevated levels of plasma matrix metalloproteinase 3 (MMP-3) during the first month after surgery which may promote the growth of residual metastases

Autor: Hiromichi Miyagaki, H. M. C. Shantha Kumara, Richard L. Whelan, Xiaohong Yan, David J. Gaita, Vesna Cekic, Sonali A. C. Herath

Publikováno v: Surgical Endoscopy. 28:3322-3328

MMP-3, a member of the matrix metalloproteinase (MMP) family, is involved in the breakdown of the extracellular matrix in tissue remodeling and may also play a role in cancer progression and metastasis. Minimally invasive colorectal resection (MICR)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835318e43a2cdd852b8eeb868f9d7eac
https://doi.org/10.1007/s00464-014-3612-9

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Minimally Invasive Colorectal Resection for Benign Pathology Is Associated With Persistent Proangiogenic Plasma Compositional Changes

Autor: Daniel Kirchoff, Richard L. Whelan, H. M. C. Shantha Kumara, Sonali A. C. Herath, Linda Njoh, Elizabeth A. Myers, Nadav Dujovny, Xiaohong Yan

Publikováno v: Diseases of the Colon & Rectum. 57:740-746

BACKGROUND Minimally invasive colorectal resection for cancer is associated with increased plasma levels of numerous proangiogenic proteins for 3 to 4 weeks postoperatively, and plasma from postoperative weeks 2 and 3 stimulates proangiogenic endothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1d2f73a457d651533d79f3ddb0227a
https://doi.org/10.1097/dcr.0000000000000062

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Perioperative polyphenon E- and siliphos-inhibited colorectal tumor growth and metastases without impairment of gastric or abdominal wound healing in mouse models

Autor: Michael Grieco, H. M. C. Shantha Kumara, Daniel Kirchoff, Richard L. Whelan, Samer A Naffouje, Sonali A. C. Herath, Joon Ho Jang, Thomas R. Gardner, Xiaohong Yan, Linda Njoh

Publikováno v: Surgical Endoscopy. 26:1856-1864

Perioperative anticancer therapy that does not impair wound healing is needed to counter the persistent proangiogenic plasma compositional changes that occur after colorectal resection. Polyphenon E (PolyE), a green tea derivative (main component EGC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b2427756b5897723a5117afcaa49d8
https://doi.org/10.1007/s00464-011-2114-2

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Plasma from the second and third weeks after open colorectal resection for cancer stimulates in vitro endothelial cell growth, migration, and invasion

Autor: Samer A Naffouje, Michael H. Grieco, Neil Hyman, Richard L. Whelan, Sonali A. C. Herath, Linda Njoh, Nadav Dujovny, Matthew F. Kalady, H. M. C. Shantha Kumara, Daniel Kirchoff

Publikováno v: Surgical Endoscopy. 26:790-795

Angiogenesis is central to wound healing and tumor growth. Postoperative (postop) plasma from weeks 2 and 3 after minimally invasive colorectal resection (MICR) stimulates endothelial cell (EC) migration (MIG), invasion (INV), and proliferation (all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcb6084e715f3b20fe64c46135f80242
https://doi.org/10.1007/s00464-011-1953-1

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Plasma soluble vascular adhesion molecule-1 levels are persistently elevated during the first month after colorectal cancer resection

Autor: Matthew F. Kalady, Sonali A. C. Herath, Anthony J. Senagore, Xiaohong Yan, Richard L. Whelan, H. M. C. Shantha Kumara, Abu Nasar, Samer Tohme, Raymond Baxter

Publikováno v: Surgical endoscopy. 26(6)

Plasma from the second and third weeks after minimally invasive colorectal resection (MICR) has high levels of the proangiogenic proteins VEGF and angiopoietin 2 and also stimulates, in vitro, endothelial cell (EC) proliferation and migration, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9af436c4f9ced6a6edde3f48925d3d9
https://pubmed.ncbi.nlm.nih.gov/22219007

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Minimally invasive colon resection is associated with a persistent increase in plasma PlGF levels following cancer resection

Autor: H. M. C. Shantha Kumara, Jenny C. Cabot, Matthew F. Kalady, Raymond Baxter, Richard L. Whelan, Daniel L. Feingold, Martin Luchtefeld, Xiaohong Yan, Sonali A. C. Herath

Publikováno v: Surgical endoscopy. 25(7)

Minimally invasive colorectal resection (MICR) is associated with persistently elevated plasma VEGF levels that may stimulate angiogenesis in residual tumor foci. Placenta growth factor (PlGF) stimulates neovascularization in tumors by modulating VEG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ac92ca6518c425952ad8602a446baf
https://pubmed.ncbi.nlm.nih.gov/21184108

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Plasma monocyte chemotactic protein-1 remains elevated after minimally invasive colorectal cancer resection

Autor: Xiaohong Yan, Linda Njoh, Martin Luchtefeld, Joon Ho Jang, Hmc Shantha Kumara, Elizabeth A. Myers, Richard L. Whelan, Vesna Cekic, Daniel Kirchoff, Sonali A. C. Herath

Publikováno v: World Journal of Gastrointestinal Oncology. 6:413

To investigate plasma Monocyte Chemotactic Protein-1 levels preoperatively in colorectal cancer (CRC) and benign patients and postoperatively after CRC resection.A plasma bank was screened for minimally invasive colorectal cancer resection (MICR) for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d0936deb4bdcd358d07eba44fb22f5
https://doi.org/10.4251/wjgo.v6.i10.413

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