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Akademický článek

Heart failure with preserved ejection fraction: present status and future directions

Autor: Somy Yoon, Gwang Hyeon Eom

Publikováno v: Experimental and Molecular Medicine, Vol 51, Iss 12, Pp 1-9 (2019)

Cardiology: Reviewing a heart disease that hides The condition known as heart failure with preserved ejection fraction (HFpEF), in which the fraction of blood pumped from the heart by each heartbeat remains near normal is an increasing cause of illne

Externí odkaz: https://doaj.org/article/55a7dae8fb7c4349b57c9f3749ce0d2c

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Akademický článek

PSME4 Degrades Acetylated YAP1 in the Nucleus of Mesenchymal Stem Cells

Autor: Yong Sook Kim, Mira Kim, Dong Im Cho, Soo Yeon Lim, Ju Hee Jun, Mi Ra Kim, Bo Gyeong Kang, Gwang Hyeon Eom, Gaeun Kang, Somy Yoon, Youngkeun Ahn

Publikováno v: Pharmaceutics, Vol 14, Iss 8, p 1659 (2022)

Intensive research has focused on minimizing the infarct area and stimulating endogenous regeneration after myocardial infarction. Our group previously elucidated that apicidin, a histone deacetylase (HDAC) inhibitor, robustly accelerates the cardiac

Externí odkaz: https://doaj.org/article/0cf339f8e6404a4faff4e0bc7c2b714e

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Akademický článek

PP2A negatively regulates the hypertrophic response by dephosphorylating HDAC2 S394 in the heart

Publikováno v: Experimental and Molecular Medicine, Vol 50, Iss 7, Pp 1-14 (2018)

Cardiovascular disease: A brake for heart muscle growth A regulatory mechanism that controls how cardiac muscle responds to stress could inform development of new therapies for preventing heart failure. Physiological stimuli ranging from heavy exerci

Externí odkaz: https://doaj.org/article/baf03256eb114ec282a4f7cff143152e

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Akademický článek

Overexpression of Heat Shock Protein 70 Improves Cardiac Remodeling and Survival in Protein Phosphatase 2A-Expressing Transgenic Mice with Chronic Heart Failure

Autor: Somy Yoon, Ulrich Gergs, Julie R. McMullen, Gwang Hyeon Eom

Publikováno v: Cells, Vol 10, Iss 11, p 3180 (2021)

Heat shock protein (HSP) 70 is a molecular chaperone that regulates protein structure in response to thermal stress. In addition, HSP70 is involved in post-translational modification and is related to the severity of some diseases. Here, we tested th

Externí odkaz: https://doaj.org/article/c6ba76c1924f43beaa622dc1a06093ae

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Akademický článek

90K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus

Autor: So-Yeon Park, Somy Yoon, Hangun Kim, Kyung Keun Kim

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 18, Iss 10, Pp 618-625 (2016)

β-Catenin is a major transducer of the Wnt signaling pathway, which is aberrantly expressed in colorectal and other cancers. Previously, we showed that β-catenin is downregulated by the 90K glycoprotein via ISGylation-dependent degradation. However

Externí odkaz: https://doaj.org/article/710b9653a7014cbe9e808e18dcbdf5e0

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Akademický článek

MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Vascular calcification (VC) increases morbidity and mortality in cardiovascular and metabolic diseases. Here, Kwon et al.show that calcification stimuli induce MDM2- mediated ubiquitination and proteasomal degradation of HDAC1, suggesting a possible

Externí odkaz: https://doaj.org/article/3cb836d24f374c4490939f3d5e417cb3

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Akademický článek

Lichen secondary metabolites in Flavocetraria cucullata exhibit anti-cancer effects on human cancer cells through the induction of apoptosis and suppression of tumorigenic potentials.

Autor: Thanh Thi Nguyen, Somy Yoon, Yi Yang, Ho-Bin Lee, Soonok Oh, Min-Hye Jeong, Jong-Jin Kim, Sung-Tae Yee, Florin Crişan, Cheol Moon, Kwang Youl Lee, Kyung Keun Kim, Jae-Seoun Hur, Hangun Kim

Publikováno v: PLoS ONE, Vol 9, Iss 10, p e111575 (2014)

Lichens are symbiotic organisms which produce distinct secondary metabolic products. In the present study, we tested the cytotoxic activity of 17 lichen species against several human cancer cells and further investigated the molecular mechanisms unde

Externí odkaz: https://doaj.org/article/5211339388b146d2a8d5d8bb38164b12

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