Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer.

Autor: Cordova RA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA., Sommers NR; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA., Law AS; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Indiana Center for Musculoskeletal Health, Indianapolis, IN 46202, USA., Klunk AJ; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Brady KE; Department of Biology, Indiana University School of Science, Indianapolis, IN 46202, USA., Goodrich DW; Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA., Anthony TG; Department of Nutritional Sciences and the New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, NJ 08901, USA., Brault JJ; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Indiana Center for Musculoskeletal Health, Indianapolis, IN 46202, USA., Pili R; Jacobs School of Medicine and Biomedical Sciences, Division of Hematology and Oncology, University at Buffalo, Buffalo, NY 14203, USA., Wek RC; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA., Staschke KA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN 46202, USA.

Publikováno v: Science signaling [Sci Signal] 2024 Nov 26; Vol. 17 (864), pp. eadp1375. Date of Electronic Publication: 2024 Nov 26.